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1

GENTIS Launches New Sperm DNA Test to Aid in Male Infertility Diagnosis

Created date : 16-11-2023

Updated date: 28-08-2024

Author: Gentis

GENTIS has officially launched the Sperm DNA test, which quantifies the percentage of fragmented sperm DNA based on dye color changes using flow cytometry (analyzing up to 10,000 sperm cells). This test helps explain recurrent miscarriages, unexplained infertility, and failed IVF attempts in couples. Notably, this test is cost-effective, making it accessible to all men.

Today, men are increasingly concerned about their reproductive health. Recognizing this, GENTIS has researched and launched the Sperm DNA test to provide a comprehensive assessment of sperm quality. This test is crucial, enabling doctors to predict a man's reproductive potential and recommend the most appropriate intervention (choosing assisted reproductive methods).

1. Why should I get a Sperm DNA test?
Sperm DNA damage can be defined as any chemical alteration from the normal structure of DNA. Among these changes, sperm DNA fragmentation (SDF) is one of the most common disorders affecting genetic material in the form of single or double-strand breaks

There are various types of sperm DNA damage, including:

Base mispairing (Caused by replication errors)
Base loss (no base at the position)
Base alteration (oxidation, alkylation, deamination)
Cross-linking and adducts (Caused by carcinogens and ROS
Single-strand breaks (SSB) and double-strand breaks (DSB) (Caused by ROS, toxic chemicals, ionizing radiation, broken replication forks)

Any changes in sperm DNA can lead to sperm DNA fragmentation (SDF) and affect the chances of natural conception or the outcome of assisted reproductive technology (ART).

Sperm DNA fragmentation is characterized by both single-strand breaks (SSB) and double-strand breaks (DSBs) of DNA, and is particularly common in the semen of men with impaired fertility. High levels of sperm DNA fragmentation are one of the causes of male infertility, affecting embryo development, implantation, and pregnancy in both natural and assisted reproduction.

Therefore, Sperm DNA served as an important supplementary test in diagnosing male infertility. This test helps doctors better screen cases of unexplained infertility, thereby guiding appropriate interventions to shorten treatment time, cost, and increase the chances of having children for couples.

2. Who should get a Sperm DNA test?

According to GENTIS experts, men should get a Sperm DNA test if they fall under the following circumstances:

* Unexplained male infertility or unclear causes.

* Recurrent miscarriages.

* Clinical symptoms of varicocele.

* Lifestyle-related risk factors.

* Before or after the failure of assisted reproductive techniques (ART) such as IUI, IVF, ICSI.

* Recurrent miscarriages after ICSI.

3. What makes the Sperm DNA test at GENTIS special?

Advanced Technology: Analysis on the Flow cytometry system (analyzing up to 10,000 sperm cells). The advantage of the Flow cytometry system is its stability, accuracy, and high performance in Sperm DNA testing.
Automated and Fast Process
Result Delivery Time: 24 hours
Cost: The most reasonable, making Sperm DNA testing accessible to all men.
With ISO-certified standards, work processes, and a team of leading experts in genetics and biotechnology, GENTIS is committed to providing customers with high-quality, affordable Sperm DNA testing and the most professional service. Notably, the Sperm DNA test provides strong support in diagnosing genetic factors related to male infertility, thereby helping doctors develop appropriate treatment regimens to overcome male infertility.