ANEUPLOID SPERM STICKER DNA ST segmentation AZF CFTR GEN MUTATION STDS TESTS

STICKER DNA ST segmentation

SPERM CHROMATIN STRUCTURE ASSAY

Amongst infertile couples, 20% is contributed by male factors alone. Continuous decline in male fertility over time, which cannot be attributed to any specific cause, results in idiopathic infertility. “Various factors underlying male infertility include varicocele, oxidative stress, genetic abnormalities, systemic disease and infections, altered lifestyle, and exposure to xenobiotics. All these factors can influence sperm DNA fragmentation (SDF), which acts as potential mediator for establishing an infertility status in men.”

“In general, semen volume, pH, sperm concentration, motility, vitality, and morphology are determined according to the WHO 2010 guidelines. Even though basic semen analysis is considered as the key investigation in all Andrology laboratories worldwide, it cannot accurately differentiate fertile from infertile men. Nearly 15% of infertile men have normal sperm parameters according to the WHO 2010”

Panner Selvam MK & Agarwal A (2018), “A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment”

WHICH PATIENTS ARE SUITABLE FOR SPERM DNA FRAGMENTATION TESTING?

Infertile patients with normal sperm parameter
Unexplained infertility, recurrent pregnancy loss
Clinical varicocele
Prior to ART
Exposed to lifestyle risk factors and environmental toxicants

REASON FOR SCSA

Reveal the cause behind male infertility
Find the cause of recurrent pregnancy loss
Assess sperm quality in a holistic approach. [*]

[*] Lê Minh Tâm et al (2019), “Phân mảnh ADN tinh trùng và sinh sản nam”, Hội nghị sản phụ khoa toàn quốc mở rộng 2019

REASON FOR SCSA AT GENTIS

GENTIS is the pioneer in genetic analysis experienced with more than 100,000 samples.

SCSA AT GENTIS
ABOUT US

Method: SCSA (Sperm Chromatin Structure Assay) – use metachromatic acridine orange to stain the DNA of sperm through flow cytometry.
Sample: 100µL sperm in SCD solution.
Run time: 2-3 days

Advantages

Gold standard in evaluating sperm DNA fragmentation (**)
High accuracy
Simple process, can report the results in a timely fahsion.

The first unit in Vietnam to have a synchronous laboratory system, 1200m2 wide in Hanoi and Ho Chi Minh City meeting international standards ISO 9001:2015
Since 2010, Gentis has successfully performed analysis of more than 200,000 samples.
There are more than 30 sample collection points across the country, ensuring to provide customers with the most convenient, fast and accurate services.
Pioneer in applying advanced genetic analysis technologies in the world such as the United States, Europe, and Korea.
GENTIS is also a place to gather a team of scientists, experienced consultants in the field of genetics, and a team of professional, enthusiastic and thoughtful technicians and consultants to bring the best services to you. quality service to customers.