Amongst infertile couples, 20% is contributed by male factors alone. Continuous decline in male fertility over time, which cannot be attributed to any specific cause, results in idiopathic infertility. “Various factors underlying male infertility include varicocele, oxidative stress, genetic abnormalities, systemic disease and infections, altered lifestyle, and exposure to xenobiotics. All these factors can influence sperm DNA fragmentation (SDF), which acts as potential mediator for establishing an infertility status in men.”
“In general, semen volume, pH, sperm concentration, motility, vitality, and morphology are determined according to the WHO 2010 guidelines. Even though basic semen analysis is considered as the key investigation in all Andrology laboratories worldwide, it cannot accurately differentiate fertile from infertile men. Nearly 15% of infertile men have normal sperm parameters according to the WHO 2010”
Panner Selvam MK & Agarwal A (2018), “A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment”
[*] Lê Minh Tâm et al (2019), “Phân mảnh ADN tinh trùng và sinh sản nam”, Hội nghị sản phụ khoa toàn quốc mở rộng 2019
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