Genetic Abnormalities in Male Infertility

Primary Causes of Male Infertility

Currently, there are many factors that contribute to male infertility. However, according to Dr. Nguyen Ngoc Nhat (Institute of Clinical Morphology, Military Medical Academy), "Genetic abnormalities are among the most severe causes of male infertility." In reality, many reports indicate that genetic factors play a crucial role in reproductive function for both men and women. Dr. Nhat further explains: "Patients may encounter abnormalities at the chromosomal level, with Klinefelter syndrome being the most common. Deeper analysis may reveal structural chromosomal abnormalities or single-gene disorders such as Kallmann syndrome."

How to Identify Genetic Factors Related to Male Infertility

Many methods have been applied to diagnose and treat male infertility. To identify genetic factors associated with male infertility, Dr. Nguyen Ngoc Nhat shares: "The first step is to conduct an examination and screening of the patient to identify symptoms or clinical phenotypes. Then, determine the sperm density in the semen. If sperm density is below 10 million per milliliter, routine karyotype testing should be recommended. In cases where sperm density is below 5 million per milliliter, both karyotype testing and assessment for AZF microdeletions should be performed. For some single-gene disorders such as mutations causing Kallmann syndrome, specific gene sequencing tests are necessary."

In his report at the 19th IVF Experts Meeting held on August 9-10, 2024, in Hue, Dr. Nhat shared that during the examination and treatment of patients, he used AZF microdeletion testing to accurately determine the deleted regions on the long arm of the Y chromosome in patients.

Dr. Nhat also emphasized that GENTIS is a reputable and experienced institution in the field of genetic analysis. Notably, GENTIS's AZF testing detects many cases of chromosomal abnormalities and AZF microdeletions in clinical practice.

GENTIS proudly offers a comprehensive range of male fertility tests for over 30 reproductive support units nationwide. Compared to other providers, GENTIS consistently demonstrates superior technology and accuracy in AZF testing. Using specific DNA segment amplification by PCR combined with capillary electrophoresis, GENTIS ensures complete coverage of AZF regions, including AZFa, AZFb, AZFc, and AZFd. As a pioneer in genetic testing technology in Vietnam, GENTIS provides modern AZF testing with accurate results and rapid turnaround times. The AZF test prices at GENTIS are considered highly reasonable and competitive, making it accessible to all interested parties.

Honored to support and provide information for Dr. Nguyen Ngoc Nhat’s report at the IVF Experts Meeting, GENTIS hopes these contributions will assist clinical doctors in screening, diagnosing, and developing appropriate treatment protocols for patients.

With two testing centers equipped with modern facilities certified to ISO 15189:2022 standards, and a team of experienced specialists and technicians, GENTIS is committed to providing the best possible experience for you and your loved ones!