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PGT testing can be divided into 3 groups according to specific purposes when genetic testing of embryos as follows:
+ PGT-A (Preimplantation Genetic Screening for Aneuploidy): Pre-implantation genetic testing helps to detect abnormalities in the chromosome number of embryos before transferring into the mother's uterus.
+ PGT-SR (Preimplantation genetic testing for structural chromosomal rearrangements): Pre-implantation genetic testing helps to detect structural chromosomal abnormalities.
+ PGT-M (Preimplantation genetic testing for monogenic/single gene defects): is a pre-implantation genetic test for single-gene diseases, indicated as embryos for couples carrying known genetic abnormalities. examines and detects embryo-specific single-gene mutations. PGT-M embryos without genetic disease will be prioritized to be transferred to the mother's uterus to eliminate single-gene genetic disease for the next generation.
Previously, PGT-M was called PGD (pre-implantation genetic diagnosis) and PGT-A was called PGS (known as preimplantation genetic screening). These two tests, when combined, can greatly improve your chances of a healthy pregnancy.
What does the PGT . test mean?
The PGT provides information about the genetic health of the embryo to help fertility professionals select the best embryos, and it also helps:
• Increase your chances of getting pregnant
• Reduce the risk of miscarriage
• More confidence when transferring single embryos, avoiding health risks when having to transplant double or triple embryos.
• Reducing the number of IVF cycles needed to conceive, which can reduce the time it takes for a successful pregnancy as well as the cost of each additional IVF session.
• Increase your chances of having a healthy baby
Who is the PGT assigned to?
1. PGT-M:
- Husband and wife carry genetic mutations that cause diseases such as Thalassemia, Myelodystrophy, ...
- Wife carries X-linked gene mutation (Hemophilia, Duchenne/Becker muscular dystrophy...)
2. PGT-SR:
- Spouse carries abnormal chromosomal structure: balanced chromosomal translocation, chromosomal deletion or duplication...
3. PGT-A:
- Miscarriage 3 times in a row
- Older wife (≥ 36 years old)
- IVF failed multiple times (≥ 3 times)
- Husband is severely infertile (loss of AZF segment)
How is PGT done?
When a PGT test is indicated:
- • The specialist performing the PGT will perform an embryo biopsy on day 3 (1 cell) or day 5 (5 to 10 blastocyst cells) to be sent for genetic testing.
• Embryos after biopsy will be frozen and ensure the principle of freezing 1 embryo / storage device.
• The embryonic cell sample after biopsy will be sent to the genetics laboratory for analysis.
• The couple will be consulted by the treating doctor about the usability of the embryos based on the genetic test results and are committed to keeping the results confidential.
• Endometrial preparation, frozen embryo transfer and pregnancy testing were performed as usual.
• The process of monitoring the pregnancy in the future still has to be done regularly under the advice of a specialist like other pregnancies.
Currently, PGT tests can be performed at some specialized hospitals or assisted reproductive centers in Vietnam, however GENTIS is one of the few pioneers, capable of performing the test. Precise and professional pre-implantation experience with the most modern advanced technical technology and a team of senior experts. Through the PGT test, GENTIS wishes to bring healthy babies and bring happiness to families across the country.
