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            [slug] => Male-infertility-due-to-sperm-dna-fragmentation-updates-on-testing-and-treatment
            [title] => Male Infertility Due to Sperm DNA Fragmentation – Updates on Testing and Treatment
            [description] => Sperm DNA plays an essential role in fertilization and embryo development. When sperm merges with the egg, the sperm's DNA carries the genetic information needed to form a healthy embryo that will develop into a complete individual. This combination not only determines the sex of the baby but also directly influences genetic traits, development, and growth potential. When sperm DNA is damaged or fragmented, the fertilization process may encounter significant barriers, such as reduced fertilization rates, impaired embryo development, increased risk of miscarriage, or compromised success rates in assisted reproductive techniques.
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Experts Join the Talkshow “Male Infertility Due to Sperm DNA Fragmentation – Updates on Testing and Treatment”
The Impact of Sperm DNA Fragmentation on Fertility and Baby Health
Sperm DNA fragmentation not only reduces the chances of conception but can also negatively affect the health and development of the baby. According to Assoc. Prof. Dr. Nguyen Quang (Director of the Andrology Center at Viet Duc Friendship Hospital), when sperm DNA is fragmented, the fertilization process may encounter difficulties, lowering the chances of successful conception. Even if conception occurs, these damages can lead to abnormal embryo development, resulting in early miscarriage or birth defects. Genetic mutations caused by damaged sperm DNA can also disrupt cell division, leading to genetic disorders and abnormalities in fetal development. This may result in serious conditions for the baby, such as genetic disorders, heart diseases, neurological problems, or issues with physical and intellectual growth. Sperm DNA fragmentation also negatively impacts assisted reproduction procedures, increasing the risk of poor embryo development. Therefore, protecting the integrity of sperm DNA is crucial not only for increasing fertility chances but also for ensuring a healthy pregnancy and a healthy baby.
Causes, Factors, and Preventive Measures for Sperm DNA Fragmentation
Each couple may have different underlying health issues contributing to sperm DNA fragmentation. The leading cause is oxidative stress. Oxidative stress occurs when there are too many free radicals in the body, typically due to increased white blood cells from infections or degenerative tissue damage. These free radicals can attack and damage sperm DNA. When sperm DNA is damaged, it may break, reducing fertility and potentially leading to issues such as miscarriage or birth defects. In addition to oxidative stress, varicocele (enlarged veins in the scrotum) is a common cause of sperm fragmentation and infertility in Vietnam. Other factors such as environmental pollution, smoking, alcohol, an unhealthy diet, stress, and unhealthy sexual practices also contribute to sperm DNA fragmentation, as shared by Assoc. Prof. Dr. Nguyen Quang.
To prevent and treat sperm DNA fragmentation, men can adopt lifestyle changes and medical treatments. Maintaining a healthy diet rich in antioxidants from vegetables, fruits, and nutritious foods can help reduce oxidative stress. Regular exercise and avoiding harmful habits like smoking and drinking alcohol will support sperm health. Moreover, limiting exposure to harmful environmental factors such as chemicals, pollution, and high temperatures is also important. According to MSc. Dr. Dinh Huu Viet (Head of the Andrology Department at Hanoi Andrology and Infertility Hospital), if necessary, medical treatments such as antioxidant supplements, vitamin C and E, or medical interventions like surgery, IVF, and ICSI can help improve sperm quality and increase fertility chances. Therefore, choosing a reputable and quality testing center is crucial to ensuring successful reproductive support. One such center is GENTIS. With 15 years of experience in genetic testing and reproductive support, modern equipment, and a team of experts, GENTIS offers high-quality services and accuracy, helping many couples achieve their dream of parenthood.
Methods for Testing Sperm DNA Fragmentation Levels
Assoc. Prof. Dr. Nguyen Quang, MSc. Resident Doctor. Vu Thu Huong, and MSc. Dr. Dinh Huu Viet
To assess the extent of sperm DNA fragmentation, advanced testing methods are increasingly used to support the diagnosis of male infertility. For assessing sperm DNA fragmentation levels, there are both direct and indirect testing methods. Among the common direct methods are the Tunel Assay and Comet Assay. MSc. Resident Doctor Vu Thu Huong (Genetics Specialist at GENTIS) explains: The Tunel Assay helps assess the level of fragmentation in each sperm cell by using DUTP to bind to the broken DNA segments. However, this method is complex and lacks standardization between laboratories. The Comet Assay also visually observes sperm DNA fragmentation under a microscope, but this test is subjective and time-consuming, making it more commonly used in research.
In addition to direct tests for sperm DNA fragmentation, indirect tests that are widely used today include Halo Sperm and SCSA. The Halo Sperm test evaluates sperm DNA fragmentation by observing the HALO ring after lysing proteins and applying a specific dye. However, the results are subjective as this test is also assessed under a microscope and highly dependent on the technician performing the test and the specialist analyzing the results, leading to less accuracy and quantification compared to SCSA.
SCSA is considered the most advanced and widely used sperm DNA fragmentation test in clinical practice today, addressing most of the drawbacks of the aforementioned tests. This method is also used to assess sperm DNA fragmentation at GENTIS. The SCSA test evaluates sperm DNA fragmentation levels using an automatic flow cytometry system to measure fluorescence signals. The method is highly accurate, fast, and automated, analyzing thousands of cells automatically, ensuring high reliability and reproducibility. This helps provide precise information on sperm DNA fragmentation levels, which is then shared with the doctor to guide treatment plans for the patient. Thanks to the outstanding advantages of SCSA testing and a team of experienced specialists and technicians, GENTIS has successfully provided valuable test information to doctors, contributing to the happiness of many couples hoping to conceive.


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            [slug] => The-role-of-reproductive-support-and-important-tests-in-in-vitro-fertilization
            [title] => The role of reproductive support and important tests in in vitro fertilization
            [description] => In Vietnam, statistics show that around 7-8% of couples of reproductive age face issues requiring reproductive support. With a population of 100 million, this means approximately 7-8 million people need consultation and support for reproductive issues; among them, over 1 million couples have a real need for reproductive support.
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Thus, the demand for reproductive support among couples in reproductive age in Vietnam is quite large. At the same time, advancements in science and technology, with many new and specialized testing techniques, including genetic testing, have been closely linked with the field of reproductive support, helping infertile and subfertile families have healthy children.
On the occasion of the Hanoi Reproductive Support Association receiving a certificate of merit from the Chairman of Hanoi People's Committee for their significant contributions to the care, protection, and enhancement of people's health in 2024, we interviewed Professor Dr. Nguyen Dinh Tao – Chairman of the Hanoi Reproductive Support Association – about the association’s contributions to reproductive support and the role of reproductive support and important tests in in vitro fertilization.
Professor Dr. Nguyen Dinh Tao (Chairman of the Hanoi Reproductive Support Association)
Interviewer: First of all, congratulations to you and the Hanoi Reproductive Support Association for receiving the certificate of merit from the Chairman of Hanoi People’s Committee for your outstanding contributions to public health in 2024.
Professor Dr. Nguyen Dinh Tao: Myself and the members of the Hanoi Reproductive Support Association are very happy that our contributions to public health in Hanoi, specifically in the field of reproductive support, have been recognized by the authorities and the city's leadership, as evidenced by the certificate of merit from the Chairman of Hanoi People's Committee.
The reproductive support industry in Vietnam has existed since 1998, and it has achieved many accomplishments in nearly 30 years. Our association, and the reproductive support branches in Hanoi, though only founded in 2019, have rapidly developed. From the start, we set specific goals, such as enhancing scientific research, training, and treatment.
For reproductive support to succeed, specialized human resources are essential, so training has always been a priority for our association since its establishment. We collaborate with Hanoi Medical University, the Military Medical Academy, and recently, even the 16A Ha Dong General Hospital, along with other institutions, to train personnel in reproductive support.
Our training programs are constantly updated to meet the specific needs of different groups. We offer hands-on training while also organizing scientific conferences where experienced professionals in reproductive support from across the country share their knowledge. Each year, the Hanoi Reproductive Support Association hosts around 4-5 scientific conferences that attract hundreds of local and international experts, doctors, and technicians. These conferences offer significant professional benefits to the workforce in reproductive support in Hanoi, keeping them up to date with both domestic and international advancements, ultimately improving patient care quality.
These scientific forums have become a trusted, high-quality, and beneficial platform for those working or intending to work in the reproductive support field. We are always committed to sharing the latest knowledge and advancements in reproductive support and genetic testing, including the achievements of genetic testing technology in reproductive support, to our colleagues in Hanoi and neighboring provinces. To achieve this, we utilize both in-person and online platforms.
GENTIS, our partner, not only participates in scientific conferences, both in-person and online, but also plays an important role in disseminating modern genetic testing technologies in Vietnam to support reproductive medicine.

Previously, many genetic tests for reproductive support had to be performed abroad at high costs. However, thanks to units like GENTIS, modern technologies and equipment are now being applied in Vietnam, contributing significantly to the development of the reproductive support industry and increasing the success rate of IVF treatments.
Therefore, reproductive support in Vietnam not only helps infertile couples achieve their dream of becoming parents, but many overseas Vietnamese have also returned to Vietnam to undergo reproductive support.
Interviewer: According to you, what factors contribute to the increasing prevalence of infertility and subfertility?
Professor Dr. Nguyen Dinh Tao: Currently, both men and women are changing their perspectives on marriage. Many young people are delaying marriage because they are focusing on their education and career first, which leads to many individuals starting to have children after the age of 30, past the "golden age" of reproduction.
Additionally, many couples are under societal pressure, constantly worried about work and financial stability. Along with unhealthy lifestyles and poor nutrition, this negatively impacts women's hormonal health and men's sperm quality.
All these factors affect reproductive quality, which is why the demand for reproductive support has increased.
I believe that the reproductive support industry emerged at just the right time to address these challenges. In the past, couples with infertility often had no choice but to rely on superstition or adopt. But today, with the advancement of scientific techniques, reproductive support has turned the impossible into possible, helping couples struggling with infertility and subfertility have the happiness of becoming parents.
Interviewer: So, Professor, what role do genetic tests play in improving IVF success rates? What are the essential and most important genetic tests during the IVF process?
Professor Dr. Nguyen Dinh Tao: The development of the genetic field has paralleled the growth of reproductive support in Vietnam. Some genetic technologies have even made remarkable advancements.

I’ve been involved in reproductive support for many years, but the development of genetics often felt like a "dream." In 2008, we organized a conference on genetics, and at that time, we thought it was unrealistic to determine whether an embryo was healthy or not. I myself conducted a state-level research project on pre-implantation genetic testing in 2012, which successfully helped couples who had multiple miscarriages or children with genetic diseases. Through the collaboration between reproductive support technology and genetic screening, they were able to have healthy children. I consider this a significant contribution of genetic testing to the field.
I believe that the combination of genetic testing and reproductive support to create healthy children is truly miraculous. If reproductive support creates embryos, genetic testing helps us determine whether those embryos are healthy or carry genetic diseases, so doctors and families can proceed confidently without concerns before embryo transfer.
In reproductive support, many tests range from basic to complex, such as health assessments, ovarian response, and semen analysis. If sperm quality is poor, we can perform tests like sperm fragmentation analysis. For families with a history of genetic disorders, genetic testing is performed to screen out any potential inherited diseases.
I strongly recommend that young couples considering marriage undergo pre-marital genetic testing to detect any genetic diseases, abnormalities, and consult doctors for advice on possible treatment.
During my research on genetic testing, I have visited medical facilities treating children with blood disorders. It was heartbreaking to see many children carrying genetic diseases who often have to be in and out of hospitals.
Interviewer: What significance does pre-implantation genetic testing (PGT) have in embryo screening before implantation? Who should undergo this test, Professor?
Professor Dr. Nguyen Dinh Tao: As I’ve mentioned, pre-implantation genetic testing (PGT) plays a crucial role in reproductive support. There are two main types of PGT: PGT-A and PGT-M.
PGT-A is a genetic screening test designed to detect chromosomal aneuploidies in embryos.
PGT-M is a test for detecting genetic mutations causing diseases inherited from one or both parents before the embryos are selected for transfer into the uterus—this helps IVF mothers give birth to healthy children. It improves embryo quality and ensures the birth of healthy babies.
PGT is a comprehensive test covering all 46 chromosomes. By performing this test before embryo transfer, we can determine whether the embryo is healthy or has any defects. If defects are found, the embryo is not transferred, and only healthy embryos are selected for transfer.
We have witnessed couples who struggled with repeated miscarriages or stillbirths due to genetic diseases. It’s heartbreaking, so applying genetic testing technology to select healthy embryos for transfer to ensure that mothers give birth to healthy children is a source of happiness and pride for those of us in reproductive support.
Interviewer: Thank you very much, Professor!
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            [title] => GENTIS accompanies the ART ADVANCED 12 Conference: “New perspectives on reproductive science: from clinical data to personalized treatment”
            [description] => The ART ADVANCED 12 conference is a significant scientific event in the field of reproductive support organized by the Hanoi Reproductive Support Association. With the theme “New Perspectives on Reproductive Science: From Clinical Data to Personalized Treatment,” the conference will provide in-depth updates and important discussions about advances in reproductive support. This is an opportunity for experts to meet, share experiences, and move towards personalized treatment to improve clinical practice outcomes.
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This year’s conference will take place on Friday, April 18, 2025, at the Pan Pacific Hotel Hanoi (1 Thanh Nien Road, Ba Dinh, Hanoi).

We are honored to accompany the conference as a sponsor. GENTIS’ booth will offer many exciting activities and attractive gifts for delegates. Additionally, the GENTIS booth will focus on presenting solutions for genetic screening and diagnosis in the field of reproductive support, particularly the three new PGT testing packages: PGT +100 rare diseases, PGT NEXT, and PGT UPGRADE.
One of the key advantages of PGT-M testing at GENTIS is the ability to analyze over 100 single-gene genetic diseases with high accuracy, allowing for the detection of even small DNA variants that may cause disease. By applying next-generation sequencing (NGS) technology combined with family-specific marker design, PGT-M ensures accuracy in identifying healthy embryos, thus increasing the chances of having a child free from genetic disorders. In addition to advanced technology, PGT-M for 100+ rare diseases also includes support from a dedicated genetic counseling team, accompanying patients before, during, and after testing.
PGT NEXT is a pre-embryo transfer genetic test capable of detecting aneuploidy on 24 chromosomes, additional abnormalities, and chromosomal deletions. It can also detect embryos with triploidy or monosomy. This helps avoid transferring embryos with these abnormalities, while also preventing wasting euploid embryos that have fertilization issues (0PN, 1PN, and 2.1/3PN). Additionally, PGT NEXT provides genetic information for embryo selection prior to transfer.
The combination of whole-genome sequencing (NGS) with SNP analysis enhances the resolution of genetic screening to detect aneuploidy. This method allows for the detection of monosomic and trisomic chromosomes, increasing the number of euploid embryos available for transfer by identifying truly diploid embryos among abnormal fertilized embryos (0PN, 1PN, 2.1PN, 3PN). Furthermore, SNP analysis ensures accurate identification of whether an embryo shares a genetic relationship with other embryos in the same group, reducing the risk of sample mix-ups due to procedural errors.
PGT UPGRADE is a pre-embryo transfer genetic test capable of detecting aneuploidy on 24 chromosomes, additional abnormalities, chromosomal deletions larger than 5 Mb, and particularly the ability to detect balanced translocations inherited from parents. Additionally, PGT UPGRADE provides genetic information for embryo selection before transfer.

At the conference, Dr. Pham Dinh Minh (Director of R&D at GENTIS) will present a report titled: "Factors Affecting the Outcome of Mosaic Embryos from a Genetic Lab Perspective."
We cordially invite doctors, embryologists, and experts to visit the GENTIS booth to update themselves on the most modern and advanced pre-implantation genetic screening solutions, serving the healthcare needs of the Vietnamese people.
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            [title] => GENTIS honored at the Vietnam's Number 1 Brand 2025 announcement ceremony
            [description] => At the Vietnam’s Number 1 Brand 2025 announcement ceremony organized by the Asian Business Development Research Center, Genetic Analysis Services Joint Stock Company (GENTIS) was honored with the “Vietnam’s Number 1 Brand 2025” award in the genetic analysis field - Gold category, as well as the “Best Medical Product/Service for Consumers in 2025” award for the PGT-Max 1 test.
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GENTIS Confirms its Position with the Vietnam’s Number 1 Brand 2025 Award in Genetic Analysis - Gold Category
The Vietnam’s Number 1 Brand announcement ceremony is an annual program organized by the Asian Business Development Research Center. The event aims to encourage and honor businesses and entrepreneurs who have continuously strived, overcome market challenges, and made positive contributions to the community, thereby fostering the country’s economy in the new era - the Era of National Growth.
The awards are selected based on international quality standards for businesses with high-quality products and services. To be recognized for the award, products must meet strict criteria, including: being a leading brand in the industry; having products and services widely recognized by consumers; demonstrating sustainable development strategies; contributing to the economy; complying with environmental, tax, customs, intellectual property, and labor regulations; and demonstrating social and community responsibility.
In addition, depending on the industry sector, the selection committee will evaluate specific criteria: capabilities; management philosophy; technology and innovation activities; financial capacity; human resources; marketing strategies, etc. GENTIS excellently met these criteria and proudly received the Gold category “Vietnam’s Number 1 Brand 2025” award in the Genetic Analysis field.
Mr. Pham Dinh Minh (R&D Director of GENTIS) Receives the Gold Cup and Certificate for Vietnam’s Number 1 Brand 2025 in Genetic Analysis
This award is a testament to the quality of GENTIS’s tests on the market and the trust and loyalty of its customers towards the GENTIS brand. It also serves as motivation for the company to continue delivering even more value to its partners and customers.
Looking at its development journey, it is evident that GENTIS has always been at the forefront of making new advancements in applying technology and building a comprehensive genetic testing ecosystem that caters to a wide range of customers. GENTIS’s product and service ecosystem continues to expand and diversify, including services for assisted reproduction, obstetrics and gynecology, andrology, hematology - immunology, oncology - pediatrics, and family testing.
Furthermore, to increase partner and customer satisfaction, GENTIS consistently focuses on improving and optimizing the testing process to save costs for patients. GENTIS also strengthens training efforts to improve the professional skills, knowledge, and expertise of its staff to meet the increasing demands of the job.
GENTIS understands that customer satisfaction comes not only from good products and services but also from comprehensive, attentive care experiences. GENTIS will continue to strive to bring more value to the community.
GENTIS Awarded Vietnam’s Number 1 Brand 2025 in Genetic Analysis - Gold Category
PGT-Max 1 Test - A Technological Breakthrough in Pre-implantation Genetic Testing
At the Vietnam’s Number 1 Brand 2025 announcement ceremony, GENTIS’s PGT-Max 1 test was honored in the “Best Medical Product/Service for Consumers” category. This is a significant milestone for GENTIS in asserting the quality of the PGT-Max 1 test.
According to experts, genetic disorders in assisted reproduction are increasingly on the rise. One method to detect genetic abnormalities in embryos is Pre-implantation Genetic Testing for Aneuploidy (PGT-Max 1). PGT-Max 1 is a pre-implantation genetic test that helps select embryos without chromosomal abnormalities (24 chromosomes), without additional mutations, or chromosomal segment deletions, optimizing the embryo selection process before IVF (in vitro fertilization), ensuring that the child born is healthy and free of the genetic abnormalities detected.
GENTIS’s PGT-Max 1 Test Recognized as the Best Medical Product/Service for Consumers in 2025
GENTIS has successfully optimized and applied the PGT-Max 1 test on embryos for many infertile couples hoping for a child. Thanks to the PGT-Max 1 test, doctors and experts can select embryos with good genetic quality, increasing the chances of successful implantation during IVF, ensuring that the child is born healthy and free from the genetic abnormalities screened.
At GENTIS, the PGT-Max 1 test is performed using advanced technologies, including NGS sequencers from Illumina (USA) and specialized bioinformatics software, with the highest sensitivity and specificity of up to 99.9%. GENTIS will also continue to strive to develop and deliver the most advanced and safest genetic testing solutions as part of its mission to enhance the physical and intellectual well-being of the Vietnamese people.
The Vietnam’s Number 1 Brand 2025 award in Genetic Analysis and the Best Medical Product/Service for Consumers in 2025 for the PGT-Max 1 test marks a milestone acknowledging GENTIS’s contributions. This will serve as motivation for GENTIS to continue its mission to “enhance the intellect and health of the Vietnamese people” in the future.
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            [title] => GENTIS collaborates with the Department of Andrology and Sexology - Hanoi University of Medicine to organize a scientific seminar
            [description] => Recently, GENTIS collaborated with the Department of Andrology and Sexology at Hanoi University of Medicine to successfully organize a scientific seminar aimed at helping doctors and healthcare staff gain a better understanding of two specialized test packages: Whole Exome Sequencing (WES) and Sperm DNA Fragmentation.

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The seminar at Hanoi University of Medicine was attended by numerous experts and doctors from the Department of Andrology and Sexology, such as Associate Prof. Dr. Nguyen Hoai Bac (Head of the Department), MSc. Dr. Tran Van Kien, MSc. Dr. Do Ich Dinh, MSc. Dr. Chu Thi Chi, and MSc. Dr. Nguyen Cao Thang. From GENTIS, the seminar was attended by MSc. Hoang Thi Nhung (Head of R&D) and MSc. NT. Vu Thu Huong (R&D Specialist).

At the beginning of the seminar, MSc. NT. Vu Thu Huong explained that high levels of sperm DNA fragmentation are one of the causes of male infertility. There are many factors that lead to sperm fragmentation. According to MSc. NT. Vu Thu Huong, Sperm DNA testing is an essential method for evaluating the overall quality of a patient's sperm. This test helps quantify the percentage of sperm DNA fragmentation by detecting color changes in a dye through a flow cytometry system (which analyzes up to 10,000 sperm), helping identify the cause of infertility in cases where the semen analysis result is normal.
In addition, the sperm DNA fragmentation test can also explain repeated miscarriages, unexplained infertility, and failed IVF attempts. Therefore, evaluating sperm quality through sperm DNA fragmentation testing is extremely necessary, as it helps doctors predict fertility potential and determine the most suitable intervention for assisted reproduction.
At GENTIS, sperm DNA fragmentation (Sperm DNA) tests are conducted using the SCSA (Sperm Chromatin Structure Assay) method, ensuring high stability, accuracy, and performance.
A unique feature of this test is the clear categorization of sperm DNA fragmentation thresholds. This helps doctors better screen cases of unexplained infertility, thus guiding treatment intervention.
In addition to the Sperm DNA fragmentation test, the seminar also featured a discussion of new information about the Whole Exome Sequencing (WES) test. According to MSc. Hoang Thi Nhung (GENTIS), WES is a DNA sequencing method aimed at analyzing the entire protein-coding region, or Exons, in the human genome. GENTIS uses next-generation sequencing (NGS) technology on the NovaSep 6000 system to sequence the entire exon region of around 22,000 genes (covering over 85% of disease-causing mutations). This allows for the detection of point mutations, small deletions/inserts, and CNVs. Whole Exome Sequencing provides the ability to diagnose genetic diseases of unknown causes, particularly rare and complex diseases, and detect genetic variants associated with neurological, cardiovascular, and other conditions.

Through the discussion, doctors from the Department of Andrology and Sexology at Hanoi University of Medicine highly appreciated the significant improvements in WES and Sperm DNA testing and posed many in-depth questions regarding these two tests. This demonstrates the interest of medical professionals in GENTIS’s WES and Sperm DNA tests. We hope that after this scientific seminar, GENTIS will continue to have the opportunity to collaborate and work with Hanoi University of Medicine in the future!
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            [slug] => The-role-and-connection-between-clinical-doctors-geneticists-and-genetic-labs-in-diagnosis-and-screening-of-genetic-diseases
            [title] => The role and connection between clinical doctors, geneticists, and genetic labs in diagnosis and screening of genetic diseases
            [description] => In modern medicine, particularly in the diagnosis and screening of genetic diseases, the collaboration between clinical doctors, geneticists, and genetic laboratories plays an extremely important role. This is a closed-loop process that ensures patients receive accurate results, supporting the best treatment and prognosis possible.
            [content] => 
The Importance of Genetic Testing in Diagnosis and Disease Screening 
According to Ms. Katie Battese Ellis (Senior Director of Medical Affairs at Illumina in several APAC countries), in the past, there were not many available tests, so doctors often gathered the patient's characteristics to identify any potential issues. However, with the development of modern medicine, numerous genetic tests are now available, making the diagnosis and screening of diseases easier.
Dr. Pham Dinh Minh, Ms. Katie Battese Ellis, and Associate Prof. Dr. Ho Sy Hung (from left to right) 
With these advancements, we can conduct pre-pregnancy tests to see if both partners are carrying the same genetic condition. Pregnant women can undergo testing to monitor fetal development. Newborn screening tests can also be performed to detect conditions that may affect the health and development of the child later on.
From the test results, geneticists and clinical doctors will discuss and create a plan for better monitoring or treatment for the patient. This not only helps save time and treatment costs but also ensures the health and future happiness of the entire family.
As one of the leading experts in reproductive medicine in Vietnam, Associate Prof. Dr. Ho Sy Hung (Deputy Director of the National Reproductive Support Center) mentioned that the collaboration between genetic experts and clinical doctors is crucial. In reproductive medicine, the success rate of pregnancy is about 50%. However, some patients experience repeated miscarriages for unknown reasons, have a history of genetic diseases, or have undergone multiple IVF cycles without success. These cases require pre-implantation genetic testing (PGT) to select healthy embryos for implantation.
Currently, there are three types of traditional PGT tests: PGT-A, PGT-SR, and PGT-M. PGT-A helps identify normal embryos and increases the chances of success in IVF. PGT-SR can detect unbalanced translocations in embryos before transfer, allowing for the selection of normal embryos, thus increasing the chances of a successful pregnancy. PGT-M is used to screen for monogenic genetic diseases, ensuring that only embryos without genetic mutations are transferred.
GENTIS is a pioneering unit in Vietnam capable of accurately and professionally performing PGT tests with the most advanced techniques, along with a team of highly qualified experts. Notably, GENTIS can screen for about 100 monogenic diseases using PGT-M.

In addition, GENTIS also offers PGT NEXT and PGT UPGRADE with outstanding advantages. PGT NEXT can detect chromosomal abnormalities on all 24 chromosomes, additional abnormalities, chromosomal segment deletions, and aneuploidy. Meanwhile, PGT UPGRADE can detect chromosomal abnormalities, segment deletions, and balanced translocations inherited from parents.
Experts Participating in the Genetic Counseling Talkshow – Discussion with Experts at GENTIS

At GENTIS, PGT testing is conducted in an ISO-standard lab using advanced genetic sequencing methods like NGS, Sanger, or PCR, carried out by skilled technicians and experienced analysts. Afterward, geneticists provide the final conclusions and send them to clinical doctors for patient consultation, ensuring the transfer of healthy embryos into the mother's uterus.
According to Dr. Pham Dinh Minh, genetic and genomic testing is booming in Vietnam. Therefore, GENTIS needs the collaboration between doctors, geneticists, and labs to make genetic tests more accessible and useful, especially in reproductive medicine, obstetrics, and newborn screening.
In the near future, GENTIS will incorporate AI and bioinformatics to screen for more diseases and provide more clinical information to assist doctors in offering the best treatment options for patients.
The Connection Between Clinical Doctors, Geneticists, and Genetic Labs 
The close collaboration between clinical doctors, geneticists, and genetic laboratories is crucial for the effectiveness of disease diagnosis and treatment. According to Ms. Katie, learning and sharing expertise is essential to strengthen cooperation among all parties.
Genetic labs should regularly update new tests, techniques, accuracy, and result turnaround times to ensure that clinical doctors and patients are better informed about the tests. This will help doctors develop the best treatment plan to save costs for patients.
Dr. Minh took Ms. Katie on a tour of the GENTIS testing center

From the clinical doctor's perspective, Associate Prof. Dr. Hung pointed out that genetic issues are challenging for both general clinical doctors and obstetricians in particular. Since tests and techniques in reproductive medicine are constantly developing and changing, continuous learning is necessary to share knowledge and assist patients.
For genetic labs, the quality of testing is the key. Based on test results, doctors can accurately diagnose diseases and develop appropriate treatment plans. Therefore, to bring new, high-quality tests to the market, the support of not only medical experts but also geneticists and technology innovators is essential, as Dr. Minh emphasized.
Based on modern medical advancements and technological progress, genetic testing is increasingly becoming an essential tool for screening and diagnosing diseases. However, to ensure maximum effectiveness, clinical doctors, geneticists, and genetic labs must work closely together. Only by functioning as a unified system can the healthcare system provide the most accurate, personalized, and optimal care for patients.
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            [slug] => Gentis-updated-information-about-2-screening-packages-PGT-NEXT-and-PGT-UPGRADE-at-An-Viet-General-Hospital
            [title] => GENTIS updated information about 2 screening packages: PGT NEXT and PGT UPGRADE at An Viet General Hospital
            [description] => Recently, GENTIS, in collaboration with An Viet General Hospital successfully held a scientific conference aimed at updating the information about 2 new PGT screening packages: PGT NEXT and PGT UPGRADE. At the event, a GENTIS representative provided detailed answers to the questions from doctors at the IVF An Viet Reproductive Center related these two advanced pre-implantation genetic testing packages.
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Attendants at the scientific seminar at An Viet General Hospital included PhD. Dr. Le Minh Chau (Head of the Obstetrics and Gynecology Department at An Viet Hospital), Dr. Mai Thi Giang (Head of the IVF Lab), Dr. Dang Van Ha (Reproductive Support Department), as well as nurses, healthcare staff, and laboratory technicians. From GENTIS, the event saw the presence of MSc. Nguyen Van Huynh (Head of R&D Department at GENTIS) and Ms. Duong Thi Phuong (Head of PM Department at GENTIS)
Throughout the seminar, MSc Huynh provided detailed presentations about PGT NEXT and PGT UPGRADE tests, highlighting the superior features of these two cutting-edge testing solutions.

Regarding PGT NEXT, MSc. Huynh explained that this is an advanced method in in-vitro fertilization (IVF) that analyzes and detects genetic changes in embryos before they are implanted in the uterus. The primary function of this test is to detect genetic disorders, gene mutations, and conditions that could cause health problems for the child or increase the risk of miscarriage.
By using Next-Generation Sequencing (NGS) technology, PGT-NEXT provides higher accuracy compared to traditional testing methods, enabling the selection of healthy embryos, reducing the risk of inherited diseases, and increasing the success rate of pregnancy. This tool is crucial for couples at high genetic risk, offering them a better chance of having a healthy baby. Additionally, this test can be extended to patients with a history of polyploid pregnancies, molar pregnancies, or recurrent miscarriages after undergoing traditional PGT-A IVF, increasing the number of embryos suitable for transfer from fertilized embryos with abnormalities (0PN, 1PN, or 2.1/3PN).
Discussing PGT-UPGRADE, MSc. Huynh mentioned that this is an advanced genetic screening method that detects embryos with balanced translocations. "Balanced translocation is a phenomenon where DNA segments are exchanged between non-homologous chromosomes without increasing or decreasing genetic material at the breakpoints. Balanced translocations are divided into two types: reciprocal translocation and Robertsonian translocation."
Compared to previous traditional PGT methods, PGT-UPGRADE uses NGS technology combined with targeted SNP sequencing, providing higher resolution in detecting aneuploidy, chromosomal structural abnormalities, and complex genetic changes. This method is especially useful for detecting small chromosomal abnormalities and balanced genetic translocations that older methods could not identify, thus helping select healthy embryos, reducing the risk of miscarriage or the birth of children with genetic disorders. PGT-UPGRADE not only increases the success rate of pregnancy but also offers great hope for couples with a history of genetic disorders or recurrent miscarriages, demonstrating its superiority in accuracy and effectiveness over older genetic screening methods.

The seminar took place in a lively atmosphere, receiving positive feedback and interest from the participating doctors. Questions related to PGT-NEXT and PGT-UPGRADE from the doctors of An Viet General Hospital were thoroughly answered by the GENTIS representatives. At the conclusion of the seminar, the doctors at An Viet General Hospital highly appreciated the two advanced tests offered by GENTIS, stating, "These tests are not only a breakthrough in medicine but also bring new rays of hope to couples on their journey to find their beloved child."
GENTIS hopes that after this informative exchange, it will continue to have the opportunity to accompany and collaborate with An Viet Hospital in the future!

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            [slug] => Happy-motherhood-journey-prenatal-class-equipping-expectant-mothers-with-useful-knowledge
            [title] => "Happy Motherhood Journey" Prenatal Class - Equipping Expectant Mothers with Useful Knowledge
            [description] => Recently, the 5th-floor hall of Hanoi Andrology and Fertility Hospital collaborated with the Happy Home AF HANOI Association successfully chaired the “Happy Motherhood Journey” prenatal class. GENTIS was honored to accompany the event as a sponsor.
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The class attracted participation of more than expectant mothers, bringing a professional and warm ambience filled with valuable insights. The prenatal class featured MSc. Dr. Hoang Van Khanh and specialist doctor level 1 Luu Ba Hung - specialists in Obstetrics and Gynecology at the Hanoi Andrology and Fertility Hospital.

With years of experiences and an amiable sharing style, the two doctors had provided useful answers related to common issues faced during pregnancy. This helped the mothers have better preparations physically and mentally for the journey of pregnancy and childbirth.

During the interactive Q&A section, a lot of practical questions were asked covering topics such as signs of preterm labor, recognizing labor contractions, and concerns regarding nutritions. The doctors not only answered the questions thoughtfully, but also shared real-life stories from their experiences treating expectant mothers, helping them better understand the challenging but joyful journey of motherhood.

The class concluded in a warm and emotional atmosphere. Not only the expectant mothers gained invaluable knowledge, but also they received meaningful gifts from the organizers as a loving reminder of the sacred journey of parenthood. 
In the future, GENTIS, in partnership with the hospital, will continue to organize more prenatal classes to accompany families in preparing a solid foundation for the arrival of their beloved babies.

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