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            [slug] => Gentis-accompanies-the-international-scientific-symposium-on-new-trends-in-sexual-health-VNU-2024
            [title] => GENTIS accompanies the international scientific symposium on new trends in sexual health VNU 2024 
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The international scientific symposium on trends in sexual health VNU 2024, organized by Y Cao institution, Hanoi university of medicine and pharmacy, in collaboration with the Vietnam Society of Sexual Medicine and the Center for Male Health & Infertility.

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The conference’s goal is to enhance the quality of sexual healthcare for Vietnamese people and connect the community of scientists both domestically and internationally. The symposium will feature 8 international speakers, who are leading experts in the field of transgender surgery and therapy. 

The VNU 2024 is a valuable opportunity for medical professionals, scientists, managers in related fields to have a comprehensive and accurate perspective in sexual health, a new and crucial field. GENTIS is honored to accompany the conference with engaging activities namely: showcasing modern genetic testing ecosystems and organizing a lucky draw with appreciation gifts for attendees.
We cordially invited the esteemed delegates, professionals, and doctors to visit GENTIS’s broth at the international scientific symposium on new trends in sexual health 2024.
Date: September 14, 2024.
Location: Nguyen Van Dao Hall - Hanoi National University, 144 Xuan Thuy, Cau Giay, Hanoi.

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The international scientific symposium on trends in sexual health VNU 2024, organized by Y Cao institution, Hanoi university of medicine and pharmacy, in collaboration with the Vietnam Society of Sexual Medicine and the Center for Male Health & Infertil
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            [slug] => Advancements-in-gêntic-and-asisted-reproduction
            [title] => Advancements in genetics and assisted reproduction. 
            [description] => Genetics and reproductive support are closely intertwined, with genetics potentially affecting any stage of reproduction. Notably, the combination of genetics and reproductive support has enabled many families struggling with infertility to fulfill their dream of parenthood and ensure the birth of healthy children. 
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According to Dr. Pham Dinh Minh (Director of R&D at GENTIS), reproductive support in Vietnam has recently evolved into a major medical specialty, significantly advancing in depth. Particularly, with recent progress in biomedical technology, especially next-generation gene sequencing, clinicians can now uncover the molecular causes of diseases, leading to personalized treatment for infertility.
From the clinical perspective, Prof. PhD. MD. Nguyen Dinh Tao notes: “As technology advances, the desire to have healthy babies free from genetic diseases is justified. Today, there are numerous reproductive support and molecular genetic techniques available. Notable tests that provide social benefits for families desiring healthy babies include PGT-A and PGT-M.”
Prof. PhD. MD. Nguyen Dinh Tao, Chair of the Vietnam Morphological Society Scientific Conference 2024
Discussing eligible subjects for genetic testing before embryo transfer, Dr. Nguyen Ngoc Diep (Army Clinical Embryology Institute) states: “In general, apart from cases where parents carry disease genes, all couples wishing for children should undergo genetic testing before implantation to ensure healthy offspring. Additionally, those at high risk for chromosomal abnormalities or those with high risks of abnormal embryo development, such as older mothers (over 35), repeated miscarriages, or a history of implantation failures, should undergo PGT-A testing. However, cases with high chromosomal abnormalities despite parents not carrying disease genes should also consider genetic testing before implantation.”
In addition to basic PGT tests for pre-implantation genetic screening, couples can also consider two special PGT packages: PGT-Max 1 and One PGT-M.

PGT-Max 1: Detects abnormalities in the 23 pairs of chromosomes and large chromosomal deletions >5Mb, as well as microdeletions from 2 Mb, such as 22q11.2 (DiGeorge Syndrome) and 1p36 deletions.
One PGT-M: Provides a streamlined process for diseases in the One PGT-M panel, reducing the testing time for rare diseases to 20 days or less.

“Both partners' reproductive health should be assessed simultaneously, including medical history, lifestyle, psychological factors, physical examination, and diagnostic tests. This helps in classifying patients based on various functional and morphological aspects, leading to differentiated treatment and diagnosis methods,” adds Associate Professor Nguyen Quang (Vietnam-Germany Friendship Hospital).
Assoc.Prof. PhD. MD. Nguyen Quang reports at the Vietnam Morphological Society Scientific Conference 2024
Assoc. Prof. Quang also emphasizes: “Genetic testing plays a crucial role in identifying the causes of infertility and reproductive support treatment. Tests such as Fertiscan (analyzing 120 genes for genetic causes of infertility in both genders), Karyotype (detecting chromosomal abnormalities), sex hormones (evaluating reproductive health), STDs (identifying common sexually transmitted pathogens), CFTR (detecting 22 CFTR gene mutations causing male infertility due to obstructive azoospermia or absent vas deferens) are essential.”
“We know that besides female infertility, male infertility is increasingly gaining attention. Genetic abnormalities are a common cause that significantly impacts reproductive health. To detect these abnormalities, besides clinical examination, genetic testing is crucial. Routine recommended tests include karyotyping and AZF microdeletion tests, especially for patients with sperm counts below 5,000,000/ml. Additionally, Fertiscan can screen for single-gene mutations related to male infertility,” adds Dr. Nguyen Ngoc Nhat (Army Clinical Embryology Institute).
Sharing clinical practice experiences in treating infertile couples, Assoc. Prof . PhD. MD Luong Thi Lan Anh notes: “Genetics and reproduction are closely linked. Utilizing technological advancements and combining various methods helps to address testing limitations, diversify disease coverage, and optimize cost and result turnaround time.”
Genetics is involved in nearly all aspects of reproductive support, including diagnosing genetic diseases, preventing them in future generations, diagnosing infertility causes, preventing recurrent miscarriages, and improving reproductive outcomes. The understanding of pathogenesis and scientific advancements have led to superior tests in reproductive support. GENTIS is proud to have the leading genetic testing center in Vietnam with advanced equipment. Notably, GENTIS is also the first institution in Vietnam to achieve international standards – ISO 15189:2022 and ISO 27001:2022, while adhering to strict Ministry of Health standards and international external quality control programs.
Currently, GENTIS offers comprehensive genetic testing to identify causes of infertility in both genders, screen for genetic abnormalities, prevent rare diseases in pre-implantation embryos, support embryo transfer, and monitor pregnancy. With advancements in genetics and reproductive support, GENTIS's genetic tests aim to assist infertile couples effectively, says Master Nguyen Thi Hue (GENTIS).
MSc. Nguyen Thi Huyen (GENTIS) reports at the Vietnam Morphological Society Scientific Conference
In reproductive support, genetic counseling has become more common, focusing on providing information about genetic disorders to patients, other health professionals, and the community. However, genetic counseling still faces challenges, including diagnostic issues, testing technology, result interpretation, counseling skills, and patient psychological support. Solutions involve enhancing knowledge, experience, and professional exchange among counselors, improving and developing testing technologies, and providing necessary psychological support for effective genetic counseling, says MSc. Nguyen Thi Huyen (GENTIS).
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            [slug] => Gentis-wins-two-major-awards-at-vietnam's-no-1-brand-awards-ceremony 
            [title] => GENTIS Wins Two Major Awards at Vietnam's No. 1 Brand Awards Ceremony.
            [description] => On the morning of August 25, at the Military Theater in Ho Chi Minh City, GENTIS was honored with two prestigious awards at the Vietnam's No. 1 Brand Awards Ceremony, organized by the Asia Business Development Research Center. This important event aims to celebrate outstanding brands and products, affirming their pioneering position in the Vietnamese market.

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The evaluation council of the Asia Business Development Research Center worked impartially and selected over 60 brands to receive the “Vietnam No. 1 Brand Awards 2024.” The selection was based on five stringent criteria:

Industry-leading brand reputation
High-quality products and services
Long-term and sustainable development strategy in the Vietnamese market
Contribution to the development of the Vietnamese economy
Social and community responsibility

Surpassing the council's evaluations, GENTIS, a genetic testing center, proudly won two awards: “Vietnam’s No. 1 Brand in Genetic Analysis” and “Best Product/Service for Consumers in 2024 for PGT-M Testing.”
GENTIS Wins “Vietnam’s No. 1 Brand in Genetic Analysis”
After over 13 years of development, this award serves as proof of GENTIS's service quality in the market and acknowledges the trust customers have in GENTIS. Participating in the Vietnam No. 1 Brand Award 2024 marks a significant step for GENTIS in establishing itself as a leading healthcare brand in the Vietnamese market and is a major milestone that propels GENTIS closer to the international market.
Genetic Analysis – GENTIS’s Pioneering Field
The award for “Vietnam’s No. 1 Brand in Genetic Analysis” recognizes GENTIS’s continuous efforts in pioneering modern genetic analysis technology, providing advanced and reliable solutions for customers. With a commitment to prioritizing quality and safety, GENTIS has firmly established its leadership in genetic analysis in Vietnam.
Genetic analysis is one of the advanced scientific fields today, helping to uncover information about genetic genes, providing insights into health, genetic disorders, and disease risk prediction. To ensure the accuracy and objectivity of genetic test results, along with investing in equipment, technology, and personnel, GENTIS places significant emphasis on building testing processes according to international standards and is accredited by global reputable organizations such as ISO 9001:2015, ISO 15189:2022, and ISO 27001:2022.
By applying modern technologies and adhering to domestic and international standards, GENTIS offers a range of genetic analysis services, from paternity testing, non-invasive prenatal screening, genetic counseling, to testing for rare genetic disorders. Each service is performed with high accuracy, adhering strictly to quality control processes to provide the most reliable and safe results for customers.
PGT-M Testing – GENTIS’s Commitment to Enhancing Reproductive Medicine
GENTIS’s PGT-M (Preimplantation Genetic Testing for Monogenic disorders) was also honored as the “Best Product/Service for Consumers in 2024.” This represents a significant advancement in supporting couples at risk of having children with monogenic genetic disorders. PGT-M helps prevent genetic disorders from parents to children, contributing to improving the quality of life and health for future generations.
At GENTIS, PGT-M testing is performed using state-of-the-art equipment and machinery, incorporating the latest NGS Illumina - USA gene sequencing system and the most advanced analytical software. Notably, the PGT-M testing process is rigorously constructed and executed to ensure the most reliable results.
GENTIS’s PGT-M Testing Recognized as the “Best Product/Service for Consumers in 2024”
Currently, PGT-M testing at GENTIS can screen for over 100 rare diseases, especially useful for couples with a family history of monogenic genetic disorders or those who have had children with genetic diseases or are carriers of disease-causing gene mutations. By screening and selecting embryos free of disease-causing genes, PGT-M helps reduce the risk of having a child with a disorder, thus enhancing the chance of having healthy children and alleviating the medical and emotional burden on families.
GENTIS is proud to be a pioneer in researching and developing PGT-M services in Vietnam. Not only providing highly accurate test results, GENTIS also brings together a team of experienced geneticists and top experts. Therefore, GENTIS is always ready to provide detailed genetic counseling to partners and customers. Additionally, GENTIS supports couples in understanding their health conditions and making the best decisions for themselves and their families.
Always Striving for the Benefit of Customers and Partners
Winning these two major awards is not only a source of pride for the entire GENTIS team but also a testament to the trust and support of customers in the company’s products and services. This will be a strong motivation for GENTIS to continue striving, continuously improving service quality, and providing optimal medical solutions to the community.

With the goal of delivering the best values to the community, GENTIS is continually working to improve technology, enhance service quality, and ensure the best benefits. The trust of customers and partners is the driving force for us to keep developing and affirming our position, deserving of the No. 1 brand award in genetic analysis in Vietnam.
The “Vietnam No. 1 Brand Awards 2024” marks a milestone recognizing GENTIS's contributions to the field of genetics and healthcare. We hope this will inspire GENTIS to continue its journey of enhancing service quality and brand reputation in the future.
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            [slug] => Genetic-abnormalities-in-male-infertility
            [title] => Genetic Abnormalities in Male Infertility
            [description] => Infertility is increasingly becoming a global issue, especially among men. According to the latest reports from the World Health Organization, approximately 1 in 6 people worldwide experience infertility, with male infertility accounting for up to 50% of these cases. This significantly impacts men's self-confidence and their family happiness.

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Primary Causes of Male Infertility
Currently, there are many factors that contribute to male infertility. However, according to Dr. Nguyen Ngoc Nhat (Institute of Clinical Morphology, Military Medical Academy), "Genetic abnormalities are among the most severe causes of male infertility." In reality, many reports indicate that genetic factors play a crucial role in reproductive function for both men and women. Dr. Nhat further explains: "Patients may encounter abnormalities at the chromosomal level, with Klinefelter syndrome being the most common. Deeper analysis may reveal structural chromosomal abnormalities or single-gene disorders such as Kallmann syndrome."

How to Identify Genetic Factors Related to Male Infertility
Many methods have been applied to diagnose and treat male infertility. To identify genetic factors associated with male infertility, Dr. Nguyen Ngoc Nhat shares: "The first step is to conduct an examination and screening of the patient to identify symptoms or clinical phenotypes. Then, determine the sperm density in the semen. If sperm density is below 10 million per milliliter, routine karyotype testing should be recommended. In cases where sperm density is below 5 million per milliliter, both karyotype testing and assessment for AZF microdeletions should be performed. For some single-gene disorders such as mutations causing Kallmann syndrome, specific gene sequencing tests are necessary."
In his report at the 19th IVF Experts Meeting held on August 9-10, 2024, in Hue, Dr. Nhat shared that during the examination and treatment of patients, he used AZF microdeletion testing to accurately determine the deleted regions on the long arm of the Y chromosome in patients.
Dr. Nhat also emphasized that GENTIS is a reputable and experienced institution in the field of genetic analysis. Notably, GENTIS's AZF testing detects many cases of chromosomal abnormalities and AZF microdeletions in clinical practice.

GENTIS proudly offers a comprehensive range of male fertility tests for over 30 reproductive support units nationwide. Compared to other providers, GENTIS consistently demonstrates superior technology and accuracy in AZF testing. Using specific DNA segment amplification by PCR combined with capillary electrophoresis, GENTIS ensures complete coverage of AZF regions, including AZFa, AZFb, AZFc, and AZFd. As a pioneer in genetic testing technology in Vietnam, GENTIS provides modern AZF testing with accurate results and rapid turnaround times. The AZF test prices at GENTIS are considered highly reasonable and competitive, making it accessible to all interested parties.
Honored to support and provide information for Dr. Nguyen Ngoc Nhat’s report at the IVF Experts Meeting, GENTIS hopes these contributions will assist clinical doctors in screening, diagnosing, and developing appropriate treatment protocols for patients.

With two testing centers equipped with modern facilities certified to ISO 15189:2022 standards, and a team of experienced specialists and technicians, GENTIS is committed to providing the best possible experience for you and your loved ones!

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            [title] => Gentis-accompanies-with-the-2024-annual-scientific-symposium-of-the-vietnam-mor-phological-society
            [description] => The XX Annual Scientific Conference of the Vietnam Morphological Society will take place from August 22-23, 2024, at Can Tho University of Medicine and Pharmacy. This year’s conference theme is “Training Models, Morphological Research, and Applications in the Digital Age,” promising to provide attendees with the latest updates from both domestic and international fields. The conference aims to offer valuable insights, enriching knowledge in the digital age, and practical skills for clinical practitioners related to morphology in general.

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Morphology plays a crucial role in the foundational and clinical training at medical universities across various specialties, including anatomy, pathology, medical genetics, histology, embryology, reproductive support, maxillofacial surgery, anthropometry, and anthropology. The teaching, research, and application of these specialties in morphology at medical schools nationwide are increasingly being promoted, contributing positively to the overall development of high-quality medical workforce training.

The XX Annual Scientific Conference of the Vietnam Morphological Society will feature an engaging program with presentations from leading experts, including:

CME Training: “Applied Anatomy in Plastic and Aesthetic Surgery” (afternoon of August 22).
Scientific Conference (August 23):

Plenary Session: “Training Models, Morphological Research, and Applications in the Digital Age.”
Session A: “Training Models and Morphological Research in the Digital Age.”
Session B: “New Advances in Genetics and Reproductive Support.”


The conference is expected to attract 300 delegates, including professors, doctors, and researchers working in fields such as anatomy, pathology, histology, embryology, reproductive support, maxillofacial surgery, genetics, anthropometry, plastic surgery, and anthropology from medical institutions and research centers both domestically and internationally.

GENTIS is honored to support this year’s conference as a sponsor and to contribute to various meaningful activities:

GENTIS representative, MSc. Dr. Nguyen Thi Huyen (R&D Specialist), will present a paper titled: "The Role of Genetic Counseling in Reproductive Support: Challenges and Difficulties."
MSc. Dr. Nguyen Thi Hue (GENTIS Genetic Counseling Center) will present a paper titled: "Application of New Genetic Tests to Enhance the Effectiveness of Reproductive Support in Vietnam."


Additionally, the GENTIS booth will feature genetic testing consultations and host various games and a lucky draw with 100% prize-winning opportunities for delegates and doctors.
We cordially invite all delegates and doctors to join us!
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            [meta_description] => The XX Annual Scientific Conference of the Vietnam Morphological Society promises to provide attendees with the latest updates from both domestic and international fields
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            [title] =>  GENTIS leads as the first to achieve 2 International ISO Certifications: ISO 15189:2022 and ISO/IEC 27001:2022
            [description] => GENTIS, a reputable entity in the field of genetic analysis, is honored to be the first laboratory in Vietnam to achieve two of the latest international ISO certifications: ISO 15189:2022 and ISO/IEC 27001:2022. This is a significant milestone that underscores GENTIS's commitment to providing high-quality genetic testing services, adhering to stringent international standards, and ensuring the highest level of information security.
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On August 13, 2024, GENTIS, the Genetic Analysis Services Joint Stock Company, held a formal ceremony to receive the ISO 15189:2022 Quality Management System certification and the ISO/IEC 27001:2022 Information Security System certification for the GENTIS EUROFINS Laboratory.

The ISO 15189:2022 VILAS MED 101 certification was assessed and granted by the Bureau of Accreditation (BoA) under the Ministry of Science and Technology of Vietnam.
The ISO/IEC 27001:2022 certification was assessed and granted by the global professional certification organization Guardian Independent Certification LTD (GICG). 

Representatives from the BoA and GICG attended the ceremony
The event was attended by representatives from the Bureau of Accreditation, including Mr. Đặng Quốc Quân, Deputy Director of the office, and Ms. Trần Thị Huyền Trang, Evaluation Specialist. Representatives from the global professional certification organization included Mr. Đặng Minh Tuấn, Director of the company, Mr. Nguyễn Hồng Diệp, Head of Evaluation Department, and Mr. Nguyễn Quốc Chiến, Evaluation Specialist. GENTIS representatives included Mr. Đỗ Mạnh Hà, General Director of the company, Mr. Hà Quốc Khanh, Quality Management Representative, and other management officials.
At the ceremony, Mr. Đặng Quốc Quân, representing the Bureau of Accreditation, expressed: “Achieving ISO 15189:2022 certification marks the beginning of a new journey, requiring continuous effort and determination from the entire GENTIS team to implement quality management. This spirit must be maintained and spread to every employee to fully realize and enhance the benefits that ISO 15189:2022 brings.”
ISO 15189:2022 - The "Gold Standard" for medical laboratories
ISO 15189 is a set of standards outlining the requirements for the quality and competence of medical laboratories. The standard has gone through three versions: ISO 15189:2003, ISO 15189:2007, and ISO 15189:2012. On December 8, 2022, the International Organization for Standardization (ISO) officially issued the fourth version of the standard, ISO 15189:2022.
The ISO 15189:2022 certification is an international standard specifically designed for medical laboratories, ensuring that laboratories operate with the highest levels of accuracy, reliability, and confidentiality. ISO 15189:2022 reflects developments and advances in the field of medical testing, emphasizing risk management, continuous improvement, and integrating quality management into all aspects of laboratory operations.
Mr. Đặng Quốc Quân, representing BoA, presented the ISO 15189:2022 certification to Mr. Đỗ Mạnh Hà, General Director of GENTIS
ISO/IEC 27001:2022 - A commitment to strict and secure information protection
ISO/IEC 27001:2022 is also the latest version of the international standard for information security management. This standard sets out specific requirements for establishing, implementing, maintaining, and continuously improving an Information Security Management System (ISMS).
The 2022 version of this standard includes several updates and improvements over the previous version (2013) to reflect changes in the global information security landscape and emerging threats. The goal of ISO 27001 is to protect the confidentiality, integrity, and availability of information by applying comprehensive risk management measures.
At the ceremony, Mr. Đặng Minh Tuấn, Director of GICG, shared: “The information security system according to ISO 27001:2022 standards will help the organization control and guide activities to ensure cybersecurity and protect customer information. GICG is also always ready to accompany GENTIS to promptly update the latest improvements and advances, bringing the best experiences to customers.”
Mr. Đặng Minh Tuấn, representing GICG, presented the ISO/IEC 27001:2022 certification to Mr. Đỗ Mạnh Hà, General Director of GENTIS
GENTIS and the mission to enhance healthcare services in genetic testing
In September 2023, GENTIS received the ISO 15189:2012 certification for its NIPT, PGT-A, and Thalassemia newborn screening services. To further affirm its efforts in building, developing, and ensuring quality for customers, GENTIS immediately improved and updated the quality in its laboratories to meet the stringent criteria of the ISO 15189:2022 version as soon as it was issued.
At the same time, in the context of personal information and medical data becoming increasingly important and sensitive, achieving ISO/IEC 27001:2022 certification also demonstrates GENTIS's strong commitment to protecting customer data. GENTIS's information security management processes and systems have been rigorously established and controlled to ensure the confidentiality, integrity, and availability of data.
Mr. Đỗ Mạnh Hà, General Director of GENTIS, proudly shared GENTIS's efforts on the journey to achieve ISO 15189:2022 and ISO/IEC 27001:2022 certifications
Achieving the two ISO 15189:2022 and ISO/IEC 27001:2022 certifications not only affirms GENTIS's quality but also reflects the company's continuous efforts to improve and enhance its services. Mr. Đỗ Mạnh Hà, General Director of GENTIS, shared: "We are extremely proud to be the pioneering genetic testing laboratory in Vietnam to achieve the ISO 15189:2022 and ISO/IEC 27001:2022 certifications. This is not only a significant achievement for GENTIS but also an important step forward in improving healthcare services in Vietnam. We are committed to continuously maintaining and enhancing quality standards to provide our customers with the best services."
These two important ISO certifications not only demonstrate GENTIS's continuous efforts in maintaining and improving service quality but also affirm the company's pioneering position in the field of genetic testing in Vietnam. GENTIS is committed to continuing to innovate and apply the latest international standards to bring the best services to customers.
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            [meta_title] =>  GENTIS leads as the first to achieve 2 International ISO Certifications: ISO 15189:2022 and ISO/IEC
            [meta_description] => GENTIS, a reputable entity in the field of genetic analysis, is honored to be the first laboratory in Vietnam to achieve two of the latest international ISO certifications: ISO 15189:2022 and ISO/IEC 27001:2022. This is a significant milestone that unders
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            [title] => GENTIS Sponsors and Presents at The 2nd congress of Vietnam Association of medical genetics and genomis and The 4th national science conference - 2024
            [description] => More than 500 delegates attended the 2nd Congress of the Vietnam Society of Medical Genetics and the 2024 National Scientific Conference, held on August 2-3, 2024, at Hanoi Medical University. This meaningful event is an annual activity organized by the Vietnam Society of Medical Genetics.
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This year's conference focused on the theme "Cancer Genetics and Updates on Advances in Medical Genetics and Genomics," featuring continuous medical education (CME) programs and an official scientific conference that included over 40 presentations on the latest and most in-depth knowledge in the field of medical genetics. The conference welcomed the participation of many genetic experts from both within and outside Vietnam, including Assoc. Prof. Dr. Tran Duc Phan, Assoc. Prof. Dr. Luong Thi Lan Anh, Assoc. Prof. Dr. Tran Van Khoa, Assoc. Prof. Dr. Nguyen Viet Nhan, Assoc. Prof. Dr. Vu Chi Dung, Prof. Dr. Kazuto Kato - Member of the WHO Genetic Advisory Board; Head of the Department of Biomedical Ethics and Social Policy at Osaka University, Prof. Dr. Dominique P. GERMAIN - University of Versailles, Raymond Poincaré University Teaching Hospital…

GENTIS was honored to accompany the conference and introduce to the delegates its comprehensive genetic testing ecosystem in the field of reproductive support using next-generation sequencing technology with the presentation titled "Application of Next-Generation Sequencing in Preimplantation Screening of Microdeletions and Duplications in Embryos" delivered by Dr. Pham Dinh Minh - Director of the GENTIS Genetic Counseling Center during the session "Updates on Advances in Genomic Medicine in Obstetrics 1."

According to Dr. Pham Dinh Minh, microdeletions and duplications in chromosomes are small chromosomal structural abnormalities that can lead to conditions including physical developmental delays, intellectual disabilities, and congenital defects. With the current preimplantation genetic testing for structural rearrangements (PGT-SR) having a resolution of 5-10Mb, smaller structural abnormalities may be missed, leading to severe consequences.

GENTIS is applying next-generation sequencing technology in preimplantation genetic screening for microdeletions and duplications in embryos. Particularly, the PGT-MAX 1 test helps detect abnormalities in the quantity of 24 chromosomes, identifies chromosomal structural abnormalities as small as 2Mb, such as 22q11.2 deletion (DiGeorge syndrome), 1p36 deletion (1p36 deletion syndrome), and other common microdeletions/duplications, and detects mosaicism (20-80%). By reducing the survey gap from 5Mb to 2Mb, the PGT-MAX1 test offers an improved solution for surveying chromosomal structural abnormalities in embryos.

Dr. Pham Dinh Minh's report demonstrated that the application of next-generation sequencing technology in preimplantation genetic screening has enhanced the effectiveness of screening for chromosomal structural abnormalities in embryos, thereby increasing the chances of successful pregnancy and healthy childbirth.

As a sponsor of the conference, GENTIS also exhibited and introduced many materials and product information on PGT in particular and GENTIS testing services in general to experts and doctors. When visiting the GENTIS booth, delegates also participated in a minigame, a lucky spin, and received valuable gifts.

The 2nd Congress of the Vietnam Society of Medical Genetics and the 2024 National Scientific Conference of the Vietnam Society of Medical Genetics provided a valuable opportunity for GENTIS to update its knowledge, engage with the international community on cancer genetics, medical genomics, and reproductive medicine. This allowed GENTIS to interact with numerous experts, introduce meaningful and practical genetic tests, and present the scientific research of its professional team to more than 500 attending delegates.

The conference was indeed a beneficial environment and an opportunity for doctors to share information, exchange knowledge, engage in scientific research, and practice to continuously improve the quality of patient care, aiming for international integration. GENTIS will continue to research and launch useful genetic tests to best support doctors in diagnosing and treating diseases.
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            [meta_description] => More than 500 delegates attended the 2nd Congress of the Vietnam Society of Medical Genetics and the 2024 National Scientific Conference, held on August 2-3, 2024, at Hanoi Medical University. This meaningful event is an annual activity organized by the V
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            [slug] => Gentis-Genetic-Counseling-Center-Successfully-Organized-Genetic-Counseling-Talks-No.-2-
            [title] => GENTIS Genetic Counseling Center Successfully Organized Genetic Counseling Talks No. 2
            [description] => With the aim of updating knowledge about genetic counseling and mosaic embryo transfer experiences for clinical doctors, embryologists, and other specialists, the GENTIS Genetic Counseling Center successfully organized Genetic Counseling Talks No. 2: Genetic Counseling in Assisted Reproductive Technology with the theme: "Mosaic Embryo Transfer and Practical Experiences in Vietnam”
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The event featured prominent speakers and chairpersons in the fields of Assisted Reproductive Technology (ART) and Medical Genetics, including Assoc. Prof. Dr. Trinh The Son (Military Medical University), Assoc. Prof. Dr. Nguyen Xuan Hoi (National Obstetrics and Gynecology Hospital), MSc. Dr. Nguyen Duy Phuong (Hanoi General Hospital), Specialist Dr. Nguyen Van Thong (Hung Vuong Hospital), Specialist Dr. Nguyen Thanh Trung (Hanoi Andrology and Infertility Hospital), MSc. Vu Dinh Chat (An Thinh Obstetrics and Gynecology Hospital), and MSc. Nguyen Quang Vinh (GENTIS).
In addition, the event attracted a large number of clinical doctors, genetic experts, embryologists, and lab specialists from hospitals and assisted reproductive centers nationwide. Notably, Genetic Counseling Talks No. 2 was honored by the presence of Prof. Dr. Nguyen Dinh Tao (President of the Hanoi Reproductive Health Society), Assoc. Prof. Dr. Tran Duc Phan (President of the Vietnam Medical Genetics Association), and Assoc. Prof. Dr. Ho Sy Hung (Deputy Director of the National Assisted Reproductive Center).
Opening the program, Assoc. Prof. Dr. Trinh The Son shared: “Mosaic embryo transfer is a topic of great interest in genetics and assisted reproduction, not only in Vietnam but also globally. Currently, doctors performing mosaic embryo transfers primarily follow the research/guidelines of various organizations such as ASRM, ESHRE, PGDIS, ISRG, etc. The number of mosaic embryos transferred has increased significantly. Therefore, standardizing the methods for mosaic embryo transfer, selecting mosaic embryos, and monitoring post-transfer outcomes are crucial.”

“At present, many associations have issued guidelines on mosaic embryo transfer, such as ESHRE and PGDIS. It is evident that these associations are focused on mosaic embryos and related issues, such as the degree of mosaicism, whether to transfers whole chromosome mosaics or segmental mosaics. 
At the ESHRE 2024 Conference, mosaic embryo transfer was a hot topic with numerous reports and discussions. A study involving 3000 mosaic embryos showed that lower levels of mosaicism resulted in better neonatal outcomes, pregnancy processes, and implantation rates compared to high-level mosaics. However, outcomes for mosaic embryos were generally lower than those for normal embryos. 
Additionally, recommendations at ESHRE 2024 indicated that embryos with over 50% mosaicism could be transferred. Studies also showed that lower levels of mosaicism correlated with better pregnancy and neonatal outcomes. Furthermore, genetic counseling is a critical step in the mosaic embryo transfer process,” said Assoc. Prof. Dr. Nguyen Xuan Hoi.
“Biological factors and technical aspects can cause mosaicism. In embryology labs, non-standardized techniques, biopsy techniques, and cell washing techniques can affect the mosaicism rate. In genetic labs, biases in gene amplification, contamination during library preparation, and initial analysis can cause mosaicism. Therefore, it is essential to establish standardized procedures between embryology and genetic labs to ensure consistent and appropriate mosaicism rates, avoid wasting embryos, and not increase the mosaicism process,” shared MSc. Vu Dinh Chat (An Thinh Obstetrics and Gynecology Hospital).

“Therefore, controlling the quality of testing is crucial. This helps control the rate of mosaic embryos and set appropriate mosaicism reporting thresholds. GENTIS has been and will continue to enhance the resolution of pre-implantation genetic testing to detect more diseases in embryos. Currently, with high-resolution NGS sequencing and specialized bioinformatics software, the PGT-Max 1 test can detect microdeletions as small as 2Mb on 24 chromosomes,” said MSc. Nguyen Quang Vinh (GENTIS).
Speaking about the practical experience of mosaic embryo transfer at Hanoi General Hospital, MSc. Dr. Nguyen Duy Phuong shared, “When receiving pre-implantation genetic testing results indicating mosaic embryos, the challenge for clinical doctors is to explain to patients what mosaic embryos are, whether they can be transferred, and how to monitor the pregnancy if transferred. In practice, monitoring a mosaic embryo pregnancy is more challenging than a normal embryo pregnancy. In addition to routine pregnancy check-ups, patients should have a NIPT test at the 10th week of pregnancy to screen for congenital defects. After that, an amniocentesis is advised at the 16th week, but the decision to proceed depends on the patient.”
“Hanoi Andrology and Infertility Hospital started mosaic embryo transfers in 2020 following PGDIS and ESHRE guidelines. Recently, the hospital has collaborated with GENTIS to conduct scientific research on 'Clinical Outcomes of Patients Transferring Mosaic Embryos.' The overall live birth rate was about 42%, showing that patients without euploid embryos for transfer can consider transferring mosaic embryos,” said Specialist Dr. Nguyen Thanh Trung.
“In practice, mosaic embryo transfer involves clinical, lab testing, and genetic counseling factors. These components are crucial in deciding mosaic embryo transfers and advising patients on the outcomes. We must agree on mosaic embryo transfers and sign consent forms to manage the follow-up process effectively. Therefore, when transferring mosaic embryos, we prioritize the lowest mosaic levels, followed by low levels. Only if patients do not allow mosaic embryo transfers, we will proceed with the next cycle to select normal embryos. Currently, international associations do not recommend discarding mosaic embryos but advise transferring them with patient consent and signed agreements,” added Assoc. Prof. Hoi.

It is evident that recommendations and guidelines for mosaic embryo transfers from global medical organizations are based on genetic factors. Speaking about the significance of genetic counseling in mosaic embryo transfers, Specialist Dr. Nguyen Van Thong (Hung Vuong Hospital) said, “Genetic doctors need to provide thorough counseling to patients to help couples understand the potential risks of transferring mosaic embryos, prioritize mosaic embryo selection, and how to monitor pre- and postnatal conditions. Moreover, psychological support is crucial to help couples reduce anxiety and stress during this process.”
The Genetic Counseling Talks No. 2 with the theme "Genetic Counseling in Assisted Reproductive Technology: Mosaic Embryo Transfer and Practical Experiences in Vietnam" was a great success. GENTIS Genetic Counseling Center sincerely thanks Assoc. Prof. Dr. Trinh The Son and the speakers, Prof. Dr. Nguyen Dinh Tao (President of the Hanoi Reproductive Health Society), Assoc. Prof. Dr. Tran Duc Phan (President of the Vietnam Medical Genetics Association), Assoc. Prof. Dr. Ho Sy Hung (Deputy Director of the National Assisted Reproductive Center), and all participants.
We look forward to welcoming doctors and specialists to future events organized by the GENTIS Genetic Counseling Center!
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            [meta_title] => GENTIS Successfully Organized Genetic Counseling Talks No. 2
            [meta_description] => The GENTIS Genetic Counseling Center successfully organized Genetic Counseling Talks No. 2: Genetic Counseling in Assisted Reproductive Technology with the theme: "Mosaic Embryo Transfer and Practical Experiences in Vietnam”

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