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European Society of Gynecology - ESG is a prestigious international organization in the field of Obstetrics and Gynecology. Since 1995, ESG conferences have brought together the world's leading experts in the field to exchange knowledge, share clinical research and professional experiences. These conferences typically occur every two years. In 2023, the 15th conference of ESG took place from November 29th to December 2nd in Amsterdam, Netherlands.
As a globally recognized organization, the scientific reports presented directly at the conference undergo a rigorous selection process. At the 2023 conference, Vietnam was honored to be the sole representative with a directly presented report from the research team of GENTIS and Hanoi Hospital of Andrology and Infertility on Preimplantation Genetic Testing for Monogenic Disorders (PGT-M).
Specialist level I Ho Van Thang, a Reproductive Medicine Specialist at Hanoi Hospital of Andrology and Infertility, along with his research team from the hospital and GENTIS, successfully submitted their research paper. After passing rigorous international peer review, they were honored to be the sole Vietnamese representative to give a live presentation at the main session on November 30th. Their presentation focused on "Initial evaluation of preimplantation genetic testing for monogenic disorders (PGT-M) in patients with single-gene genetic diseases”.
PGT-M is a genetic test that enables couples carrying genetic diseases to select embryos that are free from the specific genetic mutations causing the disease. This allows them to transfer healthy embryos to the mother's uterus, preventing the transmission of genetic disorders to the next generation. In a collaborative study conducted by GENTIS and Andrology and Infertility Hospital of Hanoi from January 2020 to May 2023 involving over 20 couples (excluding those with Thalassemia), PGT-M was used to screen embryos for various genetic disorders, including autosomal dominant (polycystic kidney disease), autosomal recessive (spinal muscular atrophy; Arthritis - kidney dysfunction - cholestasis; hemophagocytic lymphohistiocytosis; Atypical hemolytic-uremic syndrome; X-linked Duchenne muscular dystrophy; hemophilia A; hemophilia B; X-linked myotubular myopathy). The clinical outcomes demonstrated a pregnancy rate of 66.7% and a live birth rate of 29.2%.
The report highlighted the significant role of preimplantation genetic testing (PGT-M) in helping couples with monogenic disorders have healthy offspring. A close collaboration among clinical physicians, genetic specialists, and embryologists is essential for accurate diagnosis, effective treatment, and optimal outcomes for patients undergoing in vitro fertilization.
Specialist level I Ho Van Thang's presentation at the main plenary session garnered significant interest and discussion from representatives of healthcare organizations worldwide, particularly those with advanced reproductive medicine programs.
Participating in the 15th European Society of Gynecology Conference provided a valuable opportunity for GENTIS and Hanoi Hospital of Andrology and Infertility to connect with the global reproductive medicine community. The presentation showcased the results of years of dedicated research aimed at developing innovative technologies and improving treatment outcomes for infertile couples. This aligns with GENTIS's long-term goal of helping more couples realize their dream of parenthood.
