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[slug] => GENTIS-the-first-unit-in-vietnam-to-achieve-CAP-certification-for-PGT-and-NIPT-testing
[title] => GENTIS - The Unit in Vietnam to Achieve CAP Certification for PGT and NIPT Testing
[description] => On June 12, 2025, GENTIS Genetic Testing Center officially became the unit in Vietnam to achieve CAP (College of American Pathologists) certification for two tests: PGT (Pre-implantation Genetic Testing) and NIPT (Non-Invasive Prenatal Testing).
This marks an important milestone in GENTIS's 15-year journey of continuous efforts to improve the quality of genetic testing services, contributing to the physical and mental health protection of the Vietnamese people.
[content] => CAP Certification - A Milestone Affirming GENTIS's Commitment to Quality and Testing Safety
Founded in 2010, GENTIS quickly established itself as one of the most reputable genetic testing centers in Vietnam. Over the past 15 years, GENTIS has not only provided high-quality testing services but also pioneered the application of the latest technology in the field of genetics.
With a goal of protecting public health, GENTIS has always focused on applying international standards, especially in reproductive health services and prenatal screening. GENTIS’s success is not only the result of substantial investment in technology and modern infrastructure but also the continuous efforts of a team of highly trained, experienced experts.
Achieving CAP certification for the laboratories performing PGT and NIPT is a clear testament to GENTIS’s strong commitment to improving the quality of testing, safeguarding the health of the population, and contributing to the development of Vietnam's healthcare sector. The CAP certification is one of the most prestigious international accreditations that laboratories can obtain.
Mr. Tran Van Khoi, Director of LAQAS (Laboratory Quality Assurance Services), the representative and distributor of CAP in Vietnam, congratulated GENTIS on this outstanding achievement.
CAP is considered the "gold standard" in laboratory testing, with a strict evaluation system covering sample collection, processing, analysis, quality control, data security, and result storage. GENTIS meeting all these requirements clearly demonstrates its operational capacity, quality control, and reliability in each test result provided.
CAP certification is the result of a long process of rigorous testing and assessment of quality standards, and GENTIS’s achievement of this certification is a testament to its commitment to continuously improving the quality of testing and healthcare services. Especially in the context of society placing increasing importance on quality of life and health, the CAP certification further confirms that GENTIS is on the right track in providing advanced and safe services to the community.
Achieving CAP certification not only expands GENTIS’s credibility and influence domestically but also serves as a critical step towards connecting and collaborating with international partners in fields such as technology transfer, scientific research, and specialized training. GENTIS is not merely a testing center; it is gradually becoming a bridge to integrate Vietnam’s genetics field more deeply into the global landscape, contributing to improving the quality of the nation’s gene pool and building a healthier future generation.
Commitment to Enhancing the Physical and Intellectual Health of the Community
CAP Certification - A Milestone Affirming GENTIS's Commitment to Enhancing the Physical and Mental Health of the Vietnamese People
Being recognized by CAP for PGT and NIPT testing is not only a testament to the tireless efforts of the team but also a commitment by GENTIS to its mission: “Enhancing the Physical and Intellectual Health of the Vietnamese People.” This reflects its commitment to always providing accurate, safe, and confidential genetic testing services at the highest level. Each test result at GENTIS is carried out under the close supervision of experts, with standardized procedures and advanced technology.
Furthermore, GENTIS is committed to continuing investments in infrastructure, technology, and expert teams, gradually establishing itself as a pioneer in genetic testing. The CAP certification is not the final goal, but rather the beginning of a more in-depth and sustainable development phase. GENTIS will continue to strive to provide high-quality genetic healthcare services, ensuring the health of millions of Vietnamese families.
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[meta_title] => GENTIS - The Unit in Vietnam to Achieve CAP Certification for PGT and NIPT Testing
[meta_description] => On June 12, 2025, GENTIS Genetic Testing Center officially became the unit in Vietnam to achieve CAP (College of American Pathologists) certification for two tests: PGT and NIPT.
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[title] => GENTIS – The Pioneer in Vietnam to Achieve CAP Certification for PGT and NIPT Genetic Testing
[description] => On June 11, 2025, GENTIS proudly hosted a ceremony to receive the CAP (College of American Pathologists) Certification for PGT (Preimplantation Genetic Testing) and NIPT (Non-Invasive Prenatal Testing).
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With this event, GENTIS officially became the first unit in Vietnam to be internationally recognized by CAP for both PGT and NIPT genetic tests, affirming its pioneering position and exceptional expertise in the field of genetic testing.
The ceremony was attended by Mr. Tran Van Khoi, Director of the Laboratory Quality Assurance Science Joint Stock Company (LAQAS), the official representative and distributor of CAP in Vietnam. Representatives from GENTIS included Mr. Đỗ Mạnh Hà, CEO, along with members of the leadership team and experienced specialists.
GENTIS held the solemn ceremony to receive the CAP Certification for PGT and NIPT tests, marking an important milestone confirming international standards.
CAP Certification – A Global Benchmark
CAP is a prestigious global certification issued by the American Society for Pathology, a world leader in laboratory quality control. To achieve this certification, institutions must meet over 800 strict evaluation criteria, including technical infrastructure, quality control systems, analysis processes, and professional team competence.
This is the first time that a genetic institution in Vietnam has been awarded CAP certification for PGT and NIPT – two techniques that require extremely high precision, advanced technology, and strict process compliance. Achieving CAP certification for both tests confirms that GENTIS's laboratory system meets international standards in equipment, operational procedures, and professional competence.
Mr. Tran Van Khoi, Director of LAQAS, presented flowers and the CAP certificate to Mr. Phạm Đình Minh, Director of the CAP GENTIS Laboratory.
This milestone firmly establishes GENTIS’s professional competence and test quality, matching the standards of leading laboratories worldwide.
GENTIS – A Leader in Genetic Testing for Reproductive Health
The CAP certification ceremony was attended by Mr. Trần Văn Khôi, Director of LAQAS, the official representative and distributor of CAP in Vietnam, Mr. Đỗ Mạnh Hà, CEO of GENTIS, and members of the leadership team and genetic experts from the company.
In his speech, Mr. Tran Van Khoi praised GENTIS’s efforts in investing in technology and quality systems: “GENTIS’s CAP certification demonstrates the company’s serious investment in improving testing quality management. This not only proves GENTIS’s high professional competence in test results but also shows their efforts and commitment to quality management to deliver highly accurate, reliable results to patients and doctors.”
Mr. Do Manh Ha(CEO of GENTIS) shared about the journey of taking GENTIS from its pioneering beginnings to an internationally accredited laboratory.
Mr. Do Manh Ha, CEO of GENTIS, emphasized: “Achieving CAP certification is the result of many years of persistence in building an internationally recognized system. We are committed to continuing to accompany our customers and partners in the healthcare journey with high-quality, accurate, safe, and humane genetic services.”
Meeting the Growing Demand in Reproductive Health Care
With the trend towards personalized medicine and the increasing demand for prenatal screening, diagnosis, and reproductive support, the implementation of internationally certified PGT and NIPT services in Vietnam is highly meaningful:
-
PGT assists in genetic screening of embryos during the in vitro fertilization (IVF) process, helping to select healthy embryos, increase the success rate, and reduce the risk of genetic diseases.
-
NIPT helps detect chromosomal abnormalities in the fetus as early as the 10th week of pregnancy, using only a blood sample from the mother, with no invasiveness, high safety, and accuracy.
PGT and NIPT are two tests that require advanced technology, specialized knowledge, and strict quality control processes – factors that GENTIS has developed and perfected over the years. The achievement of CAP certification for these two important genetic tests is a significant event, marking a major step forward in standardizing and elevating the quality of genetic testing services in Vietnam to international standards.
Commitment to Sustainable Development and Expanding International Collaboration
During the ceremony, Mr. Do Manh Ha, CEO of GENTIS, affirmed:
“Receiving the CAP certification is an important milestone not only for GENTIS but also for the genetic testing industry in Vietnam. We are committed to continuing to invest in technology, enhance our team’s expertise, and constantly improve processes to provide accurate, safe, and humane testing services to the community.”
GENTIS is currently one of the pioneers in the field of genetic testing in Vietnam, with 15 years of development, serving millions of customers with laboratories certified to international standards including CAP, ISO 15189:2022, ISO 27001:2022, and ISO 9001:2015. The CAP certification demonstrates the strong development potential and international integration capacity of Vietnam’s biomedical industry.
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[slug] => GENTIS-accompanies-Hai-Phong-International-Obstetrics-and-Pediatrics-Hospital-in-the-Ceremony-Celebrating-1000-babies-born-from-the-IVF-center
[title] => GENTIS Accompanies Hai Phong International Obstetrics and Pediatrics Hospital in the Ceremony Celebrating "1,000 Babies Born from the IVF Center"
[description] => On June 8, 2025, GENTIS had the honor of accompanying Hai Phong International Obstetrics and Pediatrics Hospital in the meaningful event: the ceremony celebrating “Welcoming 1,000 Little Angels Born from the IVF Center.” This milestone marks a significant achievement for the IVF Center in realizing the dream of parenthood for thousands of families.
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The ceremony was attended by Professor, Doctor, Labor Hero, People’s Teacher Nguyễn Viết Tiến – Chairman of the Vietnam Obstetrics and Gynecology Association, former Deputy Minister of Health, former Director of the Central Obstetrics and Gynecology Hospital, Director of Thiện An Hospital. Also present were Dr. Hà Anh Đức – Director of the Department of Medical Examination and Treatment (Ministry of Health), ThS. Đinh Anh Tuấn – Director of the Department of Maternal and Child Protection, PGS.TS. Lê Minh Quang – Director of Hai Phong Department of Health, along with representatives from various departments, agencies, and numerous partners and businesses who have accompanied the hospital throughout its journey.
The presence of leading experts and high-level leaders is evidence of the healthcare sector’s recognition and appreciation of Hai Phong International Obstetrics and Pediatrics Hospital’s efforts and contributions to reproductive support – a field that requires deep expertise, advanced technology, and unwavering commitment to patients.
The Reproductive Support Center – IVF at Hai Phong International Obstetrics and Pediatrics Hospital was established with the mission to provide an opportunity for parenthood to thousands of infertile and couples facing difficulties in conceiving. After years of development, the Center has welcomed 1,000 babies born through IVF, serving as a vivid testament to the professionalism, dedication of the medical staff, and the trust of families.
In their speech at the ceremony, the hospital’s leadership emphasized: “Each child born is a miracle, a culmination of modern medicine, love, and perseverance. We are proud to have written this journey of love together with families, with our hearts, responsibility, and trust.”
The ceremony also provided the hospital with an opportunity to express their sincere gratitude to healthcare leaders, leading experts, collaborating units, and especially the families of patients who have trusted and chosen the IVF Center at Hai Phong Hospital in their pursuit of happiness.
During the event, many touching stories were shared – journeys of overcoming difficulties, hope, and tears, culminating in the overwhelming joy of hearing the first cries of their children. These families, once despairing because of infertility, are now living proof of the power of modern medicine and the compassion of healthcare providers.
With a team of experienced doctors, modern equipment, and support from leading experts both domestically and internationally, the IVF Center at Hai Phong International Obstetrics and Pediatrics Hospital is increasingly establishing itself as one of the top reputable addresses for reproductive support in the North.
As the hospital enters a new stage of development, it will continue to invest in expertise, upgrade technology, expand international collaborations, and continuously improve service quality to bring more trust and happiness to an increasing number of families.
The ceremony marking the birth of 1,000 IVF babies is not only a source of pride but also a commitment to continue “planting seeds of life,” accompanying the unfinished dreams of parenthood. A new journey is opening, continuing the miracles born from love and modern medicine.
As a strategic partner in genetic testing for reproductive support, GENTIS is committed to accompanying healthcare facilities in enhancing the quality of infertility and reproductive care in Vietnam. During the event, GENTIS provided expert information on:
-
Preimplantation Genetic Testing (PGT)
-
Genetic counseling for IVF support
-
Screening tests before and during pregnancy
-
Early detection of genetic abnormalities in newborns
Through advanced technologies, GENTIS aims to work alongside doctors and medical experts to improve the success rate of IVF and ensure the birth of healthy, well-developed babies.
The event served as a time for healthcare professionals, families, and partners to reflect on the emotional and meaningful journey – a place where medical trust and the application of modern genetic technology converge, giving wings to thousands of happiness stories. GENTIS extends its congratulations to the IVF Center at Hai Phong International Obstetrics and Pediatrics Hospital and hopes to continue accompanying healthcare facilities in the mission of providing comprehensive, effective, and humane reproductive health care.
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[slug] => GENTIS-launches-advances-obstetrics-and-pediatrics-genetic-testing-methods-at-the-2nd-expanded-nghe-an-obstetrics-and-pediatrics-scientific-conference-2025
[title] => GENTIS Launches Advanced Obstetrics and Pediatrics Genetic Testing Methods at the 2nd Expanded Nghe An Obstetrics and Pediatrics Scientific Conference 2025
[description] => On May 30–31, GENTIS was honored to accompany the 2nd Expanded Nghe An Obstetrics and Pediatrics Scientific Conference 2025 as a sponsor. In addition to offering engaging activities and attractive gifts at its exhibition booth, GENTIS also showcased its most advanced genetic testing solutions in the field of Obstetrics and Pediatrics. The eye-catching GENTIS booth attracted significant interest from many delegates who stopped by to explore and engage with the team.
[content] => 
At this year’s Obstetrics and Pediatrics event, GENTIS introduced a wide range of advanced genetic testing methods to the conference, including GEN9, 77 IEMs, biotinidase deficiency screening (SLSS), and notably, three new PGT packages: PGT-M for over 100 rare diseases, PGT NEXT, and PGT UPGRADE.
One of the standout features of the PGT-M 100+ test at GENTIS is its ability to detect more than 100 monogenic (single-gene) inherited disorders with high accuracy. By applying next-generation sequencing (NGS) technology in combination with family-specific marker design, PGT-M 100+ can precisely identify even the smallest DNA variants—factors that could potentially lead to disease. This allows the identification of embryos free of disease-causing genes, increasing the chances of a healthy baby. In addition to cutting-edge technology, the PGT-M service at GENTIS is supported by a team of experienced genetic counselors who provide comprehensive guidance before, during, and after testing.
PGT NEXT is a preimplantation genetic screening method that detects aneuploidy across all 24 chromosomes and identifies chromosomal segmental gains or losses. It can also detect embryos with polyploidy or monoploidy—conditions often excluded due to suspected fertilization abnormalities (such as 0PN, 1PN, 2.1PN, 3PN). By analyzing the entire genome with NGS and SNP genotyping, PGT NEXT increases the accuracy of chromosomal abnormality detection and ensures correct kinship identification among embryos in the same batch, thereby minimizing the risk of sample mix-ups due to handling errors.
PGT UPGRADE is an advanced version of preimplantation genetic testing, capable of detecting aneuploidy across all 24 chromosomes and identifying segmental chromosomal abnormalities larger than 5 Mb. Notably, this test can also detect balanced translocations—genetic abnormalities that may be inherited from either parent, which do not necessarily manifest as disease but can affect reproductive health in future generations. PGT UPGRADE provides in-depth genetic information, helping to optimize embryo selection and increasing the chances of successful pregnancy and healthy offspring.
GEN9 is a pre-marital or pre-pregnancy genetic screening test that detects 9 autosomal recessive genetic disorders, including: Alpha-Thalassemia, Beta-Thalassemia, G6PD deficiency, Phenylketonuria, Galactose metabolism disorder, Citrin deficiency-related jaundice, Pompe disease, Wilson disease, 5-alpha reductase deficiency type 2, and Fabry disease. GEN9 evaluates the risk of parents passing on genetic disorders to their children and provides reproductive support to eliminate disease-causing genes.
The 77 IEMs and SLSS biotinidase deficiency tests are two critical newborn screening methods performed shortly after birth to detect congenital disorders early. The 77 IEMs test identifies over 70 different metabolic disorders, including amino acid, fatty acid, and organic acid metabolism disorders. Meanwhile, the SLSS test detects biotinidase deficiency, a vital enzyme in biotin metabolism. Both tests play an essential role in identifying conditions that may not present obvious symptoms initially. Early diagnosis allows timely medical intervention, reducing the risk of severe complications and improving newborn health outcomes.
The GENTIS exhibition booth attracted significant attention from delegates and attendees. At the booth, doctors’ questions regarding GENTIS genetic testing services were thoroughly and clearly addressed. Notably, healthcare professionals expressed high appreciation for GENTIS’s genetic testing solutions in the field of obstetrics and pediatrics.
Through this event, GENTIS hopes to continue partnering with doctors, specialists, hospitals, and clinics on the journey to make accurate, timely genetic testing more accessible to Vietnamese people. With a mission to contribute to improving the physical and intellectual well-being of the Vietnamese population, GENTIS is committed to continuously updating, researching, and developing genetic testing services to enhance the quality of screening and healthcare in the community.
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[title] => Children’s Day June 1st - GENTIS Sends Love Through Adorable Teddy Bears
[description] => International Children’s Day on June 1st is not only an occasion for children to have fun and receive meaningful gifts, but also a chance for GENTIS to accompany parents on their journey of love and protection for their children from the very first days of life.
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On the occasion of International Children’s Day on June 1st, GENTIS is pleased to offer adorable teddy bears as gifts to couples who register for Newborn Screening (SLSS) tests at the following hospital locations:
These cute teddy bears will be a heartfelt gift from GENTIS to the babies who are soon to be born.
Newborn screening is a vital test to detect early genetic disorders such as congenital hypothyroidism, G6PD deficiency, congenital adrenal hyperplasia, and more. Early detection and timely treatment will help your child grow up healthy and develop like any other child.
With an ISO-certified testing process, advanced technology, and a team of highly skilled specialists, GENTIS is proud to be a pioneer in genetic testing, always prioritizing safety, accuracy, and dedication.
Program Duration: From June 1, 2025, to June 30, 2025.
Gift quantities are limited, and the program may end early if all gifts are distributed.
Let this small gift from GENTIS convey our best wishes for your baby’s strong and complete start in life!
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[title] => GENTIS demonstrates its commitment to community responsibility through the journey of a french director searching for his birth mother in Vietnam
[description] => On May 21, 2025, a heartwarming story came to a close with an emotional reunion hug after 31 years of separation: French-Vietnamese filmmaker Arthur Chareire found his biological mother, Ms. Nguyễn Thị Hợi, in Vietnam. This miraculous journey was not only the result of Arthur's determination to reconnect with his roots, but also thanks to a silent yet pivotal factor: the support of GENTIS — a pioneer in genetics that facilitated the DNA testing between Arthur and his mother. GENTIS’s involvement in this journey is a clear testament to the company’s commitment to community responsibility — one of the core values it has always upheld and pursued.
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A Journey Spanning Over Three Decades and the Longing to Say “Mom”
Arthur Chareire was born in 1994 at Bạch Mai Hospital in Hanoi. Just a few days after birth, the baby named Vũ Văn Dậu — Arthur’s birth name — was adopted by a French family. Though raised in a loving home, Arthur always felt an unfillable void: the absence of the woman who gave birth to him in Vietnam. Driven by a deep yearning to return to his origins, Arthur began a sacred quest to find his biological mother. He shared his personal information, birth certificate, and photos on social media in the hopes of finding a clue.
His post quickly went viral and eventually reached Ms. Nguyễn Thị Hợi — a woman who had given birth around the same time at Bạch Mai Hospital. After multiple conversations and verification of the details, the two decided to proceed with a DNA test to confirm their biological relationship. This was the moment when GENTIS joined the filmmaker in his sacred journey.
GENTIS — A DNA Testing Organization That Puts People First
Colonel Hà Quốc Khanh, former Deputy Director of the Institute of Criminal Science under the Ministry of Public Security and Senior Advisor at GENTIS, announced the DNA test results.
With nearly 15 years of experience in genetic testing, GENTIS is recognized as one of Vietnam’s most trusted institutions for paternity, genetic, and prenatal screenings. However, for GENTIS, testing is more than a scientific service — it is a means to serve higher values: truth, family, and justice. Understanding the emotional significance of this journey, GENTIS proactively covered all testing costs for Arthur and Ms. Hợi — a gesture that clearly reflects the company’s commitment to the community and to those in need of reconnection, guided by compassion rather than limited by finances.
The DNA testing process was carried out by GENTIS with absolute accuracy and in strict adherence to international standards. The GENTIS team analyzed and compared Arthur and Ms. Hợi’s DNA samples in a modern, transparent laboratory setting. Just a few days later, the result was revealed: they are indeed mother and son.
More Than a Test — A Mission
Ms. Nguyễn Thị Hợi, biological mother of French director Arthur Chareire, provides her DNA sample at GENTIS.
Arthur and his mother’s story is not unique. Every year in Vietnam, thousands of people long to reunite with their birth parents, and countless parents hold onto hope of seeing a lost child again. In these emotional and often challenging journeys, GENTIS plays a role beyond just providing DNA testing services — it becomes a bridge of humanity, supporting compassion and reunion.
For GENTIS, community responsibility goes beyond accurate results — it’s reflected in meaningful actions such as offering free or discounted services for those in difficult circumstances and sharing scientific knowledge transparently and accessibly. With dedication and empathy, GENTIS believes that every DNA sample is not just a string of genetic code, but a chance to heal lives, reignite hope, and continue writing stories of heartfelt reunions.
The Journey Is Not Over — A Future of Reconnection
Arthur is expected to return to Vietnam in November 2025 to meet his mother in person, following their first reunion via video call. He shared, “I don’t blame my mother. On the contrary, I am grateful that she gave me life. Thank you, GENTIS, for giving me the certainty to call someone ‘Mom’ again without doubt.”
Arthur’s story is a powerful example of how technology, guided by compassion, can create profound meaning. And GENTIS is proud to walk alongside these sacred moments, serving as a bridge for millions of hearts searching for each other across life’s many crossroads.
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[slug] => GENTIS-accompanies-the-2nd-expanded-obstetrics-and-pediatrics-scientific-conference-of-Nghe-An-in-2025
[title] => GENTIS Accompanies the 2nd Expanded Obstetrics and Pediatrics Scientific Conference of Nghe An in 2025
[description] => The 2nd Expanded Obstetrics and Pediatrics Scientific Conference of Nghe An in 2025 is a significant scientific event in the field of reproductive health, organized by the Nghe An Obstetrics and Pediatrics Hospital. This is not only an important event for medical professionals but also a memorable milestone marking the 40-year development journey of Nghe An Obstetrics and Pediatrics Hospital (June 1, 1985 – June 1, 2025). It is a valuable opportunity for learning and also an occasion for GENTIS to demonstrate its commitment to the sustainable development of Vietnam’s healthcare sector.
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This year’s conference will take place on Friday and Saturday, May 30–31, 2025, at Giao Te Hotel – No. 9 Ho Tung Mau Street, Hung Binh Ward, Vinh City, Nghe An Province.
As a sponsor accompanying this conference, GENTIS is honored to contribute in a small but meaningful way to this important event. The GENTIS booth at the event will showcase advanced testing methods in obstetrics and pediatrics, particularly highlighting three new PGT (Preimplantation Genetic Testing) packages: PGT-M 100+ for rare diseases, PGT NEXT, and PGT UPGRADE.
One outstanding feature of the PGT-M 100+ test at GENTIS is its ability to detect over 100 single-gene disorders with high accuracy. By using next-generation sequencing (NGS) technology combined with family-specific marker design, PGT-M 100+ can precisely detect even minor DNA variations—hidden factors that can lead to disease. This method allows for the identification of embryos that are free from disease-causing genes, thereby increasing the chance of having a healthy baby. In addition to using advanced technology, GENTIS’s PGT-M service includes comprehensive support from a team of experienced genetic counselors, assisting clients before, during, and after testing.
PGT NEXT is a preimplantation genetic screening method that detects aneuploidies across all 24 chromosomes and identifies structural abnormalities such as chromosomal deletions and duplications. This test can also detect embryos with polyploidy or haploidy—conditions often discarded due to suspected fertilization abnormalities (e.g., 0PN, 1PN, 2.1PN, 3PN). By analyzing the entire genome using NGS combined with SNP genotyping, PGT NEXT increases the accuracy of chromosomal abnormality detection and ensures the correct identification of genetic relationships among embryos within the same group, minimizing the risk of sample mix-ups due to human error.
PGT UPGRADE is an enhanced version of preimplantation genetic testing, capable of detecting not only aneuploidies across 24 chromosomes but also structural chromosomal abnormalities larger than 5 Mb. Notably, this test can identify embryos carrying balanced translocations—a genetic abnormality that may be inherited from a parent without showing symptoms but can impact the reproductive health of future generations. PGT UPGRADE provides in-depth and detailed genetic information, optimizing embryo selection before transfer, thereby improving the likelihood of successful pregnancy and healthy offspring.
In addition, GENTIS will also introduce three new tests at the Nghe An Obstetrics and Pediatrics Scientific Conference: GEN9, 77 Inherited Metabolic Disorders (77IMDs), and SLSS Biotinidase Deficiency Screening.
GEN9 is a pre-marital/pre-pregnancy genetic screening test that screens for 9 recessive single-gene disorders such as Alpha-thalassemia, Beta-thalassemia, G6PD deficiency, phenylketonuria, galactose metabolism disorder, citrin deficiency-related cholestatic jaundice, Pompe disease, Wilson disease, 5-alpha-reductase type 2 deficiency, and Fabry disease. GEN9 helps assess the risk of passing genetic conditions to offspring if both parents are carriers, allowing for timely reproductive planning and support to eliminate disease-causing genes.
The 77IMDs test and SLSS Biotinidase Deficiency Screening are two essential newborn screening methods to detect congenital disorders early. The 77IMDs test screens for over 70 metabolic disorders, including issues with amino acid, fatty acid, and organic acid metabolism. Meanwhile, SLSS Biotinidase Deficiency Screening detects a deficiency in the biotinidase enzyme, crucial for biotin metabolism. These tests are vital in identifying conditions that may not present symptoms at birth. Early diagnosis allows for timely medical intervention, reducing the risk of severe complications and improving the quality of life for newborns.
Let’s welcome the 2nd Expanded Obstetrics and Pediatrics Scientific Conference of Nghe An, a significant event marking progress and success in Vietnam’s healthcare sector!
We look forward to welcoming distinguished delegates at the GENTIS booth!
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[slug] => Male-infertility-due-to-sperm-dna-fragmentation-updates-on-testing-and-treatment
[title] => Male Infertility Due to Sperm DNA Fragmentation – Updates on Testing and Treatment
[description] => Sperm DNA plays an essential role in fertilization and embryo development. When sperm merges with the egg, the sperm's DNA carries the genetic information needed to form a healthy embryo that will develop into a complete individual. This combination not only determines the sex of the baby but also directly influences genetic traits, development, and growth potential. When sperm DNA is damaged or fragmented, the fertilization process may encounter significant barriers, such as reduced fertilization rates, impaired embryo development, increased risk of miscarriage, or compromised success rates in assisted reproductive techniques.
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Experts Join the Talkshow “Male Infertility Due to Sperm DNA Fragmentation – Updates on Testing and Treatment”
The Impact of Sperm DNA Fragmentation on Fertility and Baby Health
Sperm DNA fragmentation not only reduces the chances of conception but can also negatively affect the health and development of the baby. According to Assoc. Prof. Dr. Nguyen Quang (Director of the Andrology Center at Viet Duc Friendship Hospital), when sperm DNA is fragmented, the fertilization process may encounter difficulties, lowering the chances of successful conception. Even if conception occurs, these damages can lead to abnormal embryo development, resulting in early miscarriage or birth defects. Genetic mutations caused by damaged sperm DNA can also disrupt cell division, leading to genetic disorders and abnormalities in fetal development. This may result in serious conditions for the baby, such as genetic disorders, heart diseases, neurological problems, or issues with physical and intellectual growth. Sperm DNA fragmentation also negatively impacts assisted reproduction procedures, increasing the risk of poor embryo development. Therefore, protecting the integrity of sperm DNA is crucial not only for increasing fertility chances but also for ensuring a healthy pregnancy and a healthy baby.
Causes, Factors, and Preventive Measures for Sperm DNA Fragmentation
Each couple may have different underlying health issues contributing to sperm DNA fragmentation. The leading cause is oxidative stress. Oxidative stress occurs when there are too many free radicals in the body, typically due to increased white blood cells from infections or degenerative tissue damage. These free radicals can attack and damage sperm DNA. When sperm DNA is damaged, it may break, reducing fertility and potentially leading to issues such as miscarriage or birth defects. In addition to oxidative stress, varicocele (enlarged veins in the scrotum) is a common cause of sperm fragmentation and infertility in Vietnam. Other factors such as environmental pollution, smoking, alcohol, an unhealthy diet, stress, and unhealthy sexual practices also contribute to sperm DNA fragmentation, as shared by Assoc. Prof. Dr. Nguyen Quang.
To prevent and treat sperm DNA fragmentation, men can adopt lifestyle changes and medical treatments. Maintaining a healthy diet rich in antioxidants from vegetables, fruits, and nutritious foods can help reduce oxidative stress. Regular exercise and avoiding harmful habits like smoking and drinking alcohol will support sperm health. Moreover, limiting exposure to harmful environmental factors such as chemicals, pollution, and high temperatures is also important. According to MSc. Dr. Dinh Huu Viet (Head of the Andrology Department at Hanoi Andrology and Infertility Hospital), if necessary, medical treatments such as antioxidant supplements, vitamin C and E, or medical interventions like surgery, IVF, and ICSI can help improve sperm quality and increase fertility chances. Therefore, choosing a reputable and quality testing center is crucial to ensuring successful reproductive support. One such center is GENTIS. With 15 years of experience in genetic testing and reproductive support, modern equipment, and a team of experts, GENTIS offers high-quality services and accuracy, helping many couples achieve their dream of parenthood.
Methods for Testing Sperm DNA Fragmentation Levels
Assoc. Prof. Dr. Nguyen Quang, MSc. Resident Doctor. Vu Thu Huong, and MSc. Dr. Dinh Huu Viet
To assess the extent of sperm DNA fragmentation, advanced testing methods are increasingly used to support the diagnosis of male infertility. For assessing sperm DNA fragmentation levels, there are both direct and indirect testing methods. Among the common direct methods are the Tunel Assay and Comet Assay. MSc. Resident Doctor Vu Thu Huong (Genetics Specialist at GENTIS) explains: The Tunel Assay helps assess the level of fragmentation in each sperm cell by using DUTP to bind to the broken DNA segments. However, this method is complex and lacks standardization between laboratories. The Comet Assay also visually observes sperm DNA fragmentation under a microscope, but this test is subjective and time-consuming, making it more commonly used in research.
In addition to direct tests for sperm DNA fragmentation, indirect tests that are widely used today include Halo Sperm and SCSA. The Halo Sperm test evaluates sperm DNA fragmentation by observing the HALO ring after lysing proteins and applying a specific dye. However, the results are subjective as this test is also assessed under a microscope and highly dependent on the technician performing the test and the specialist analyzing the results, leading to less accuracy and quantification compared to SCSA.
SCSA is considered the most advanced and widely used sperm DNA fragmentation test in clinical practice today, addressing most of the drawbacks of the aforementioned tests. This method is also used to assess sperm DNA fragmentation at GENTIS. The SCSA test evaluates sperm DNA fragmentation levels using an automatic flow cytometry system to measure fluorescence signals. The method is highly accurate, fast, and automated, analyzing thousands of cells automatically, ensuring high reliability and reproducibility. This helps provide precise information on sperm DNA fragmentation levels, which is then shared with the doctor to guide treatment plans for the patient. Thanks to the outstanding advantages of SCSA testing and a team of experienced specialists and technicians, GENTIS has successfully provided valuable test information to doctors, contributing to the happiness of many couples hoping to conceive.
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