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+ Genetic tests for diagnostic screening related to infertility examination and treatment.
+ Important and necessary notes when providing genetic counseling for cases requiring genetic diagnostic screening tests.
- Part 2: CASE STUDIES
- Part 3; Q&A WITH EXPERTS
+ All the aforementioned information will be shared with the audience in the talk show featuring:
+ MSc. Dr. Nguyen Ngoc Nhat - Military Clinical Embryology Institute
+ MSc. Dr. Nguyen Thi Huyen - GENTIS Genetic Counseling CenterMSc. Dr. Nguyen Thi Hue - GENTIS Genetic Counseling Center
[content_more] => [meta_title] => TALK SHOW genetic counseling for Karyotype testing, panel gene for male and female infertility [meta_description] => Genetic talk show - Discussion with experts: Genetic counseling for karyotype testing, panel genes for male and female infertility. [meta_keyword] => GENTIS,karyotype,reproductive assistance [thumbnail_alt] => [post_id] => 1248 [category_id] => 4 ) [1] => stdClass Object ( [id] => 1247 [id_crawler] => [category_product] => NULL [thumbnail] => dsc09707.jpg [album] => [url_video] => [is_status] => 1 [is_featured] => 0 [is_form] => 0 [displayed_time] => 2024-09-23 [program] => 0 [number] => 1 [viewed] => 0 [type] => [type_career] => [level] => [address] => [address_career] => [expiration_time] => 0000-00-00 [created_time] => 2024-09-23 09:30:20 [updated_time] => 2024-10-03 09:45:06 [files] => [salary] => [time] => [created_by] => 63 [is_table_content] => 1 [language_code] => en [slug] => Genetic-counseling-for-karyotype-testing-and-gene-pannels-for-male-and-female-infertility [title] => Genetic counseling for Karyotype testing and gene panels for male and female infertility [description] => To help people gain more knowledge about genetics and understand the current state and prevalence of infertility in Vietnam, on September 20, 2024, the GENTIS Genetic Counseling Center hosted the fourth episode of the Genetic Counseling Talkshow, titled "Genetic Counseling: Karyotype Testing and Gene Panels for Male and Female Infertility." This event featured experts ThS.BSNT Nguyen Ngoc Nhat (Military Clinical Embryology Institute), ThS.BSNT Nguyen Thi Huyen, and ThS.BSNT Nguyen Thi Hue (GENTIS Genetic Counseling Center). [content] =>
According to a WHO report, approximately 17.5% of the reproductive-age population—about 1 in 6—experiences infertility issues, highlighting the urgent need to enhance access to high-quality reproductive healthcare services for those in need.
MsC and resident physician Nguyen Ngoc Nhat (Military Clinical Pathology Institute) shared at the talk show on genetic counseling, Karyotype testing, and gene panels for male and female infertility.
Dr. Nguyen Ngoc Nhat stated, “Infertility is the failure of a couple to conceive after one year of regular unprotected intercourse. Statistics and studies show that infertility is a social issue that is increasingly on the rise, especially in the current context. In the past, infertility was often attributed to female factors such as ovulatory disorders, anatomical abnormalities of the uterus, and fallopian tube blockages. However, in the last decade, many studies have indicated that approximately 50% of infertility cases can be traced back to male factors, including mumps, other medical conditions, sperm abnormalities, sperm density less than 5 million/ml, and azoospermia. Notably, the primary cause of these issues is genetic abnormalities.”
“Currently, genetic testing is an essential component of diagnosing and treating infertility. With advancements in technology and ongoing research, about 25% of previously unexplained infertility cases are now identified as potentially having a genetic basis. Genetic tests such as Karyotype, AZF, and Fertiscan play a crucial role in determining the underlying causes of infertility and guiding treatment for couples facing these challenges,” Dr. Nguyen Thi Huyen added.
Three experts will accompany the talk show "Genetic Counseling: Karyotype Testing and Gene Panels for Male and Female Infertility."
"GENTIS is a pioneering organization in Vietnam in researching and developing useful tests in the field of reproductive assistance, such as Karyotype, AZF, Fertiscan, and more. Notably, these are complex, in-depth tests that require strict adherence to many rigorous standards during execution. Specifically, this includes modern machinery, highly trained technicians, and an experienced team for result analysis who continuously learn and pay special attention to sample collection and preservation to ensure no contamination occurs, thereby providing high-quality tests for patients," said Master of Science, Specialist Nguyen Thi Hue.
“In reality, genetic abnormalities are quite common in patients with infertility. In addition to medical examinations, genetic counseling is also very important. It should be tailored to each specific case to help patients understand their conditions. For those with infertility who have already received genetic test results, it’s essential to consider the issues the patient faces, the possible examination and treatment options, and their desires and circumstances to provide appropriate and comprehensive advice,” Dr. Huyen added.
During the discussion, the doctors promptly shared and addressed questions, helping physicians, experts, and couples hoping for children gain a better understanding of the causes of infertility in both men and women, as well as common tests used to evaluate these causes, such as karyotype testing and genetic mutation screenings. The talk show was a success, attracting over 500 views, many shares, and numerous questions from doctors, experts, and couples wishing for children.
The talk show concluded successfully, and GENTIS promises to continue offering more programs to serve physicians and clients
We hope that the insights shared by experts during the talk show will be beneficial for doctors and the audience in providing genetic counseling for Karyotype testing and gene panels for male and female infertility, helping to identify the causes of infertility. This will enable doctors to offer necessary advice to couples wishing for children, contributing to higher success rates in IVF and the arrival of healthy babies.
The GENTIS Genetic Counseling Center sincerely thanks the doctors, partners, experts, and clients for their participation and support. We will continue to organize more Talk Show programs on genetic counseling and discussions with experts to provide the audience with valuable information.
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At the VNU 2024 international scientific conference themed “Updating New Trends in Sexual Health,” organized by the Vietnam Society of Sexual Medicine in collaboration with the University of Medicine and Pharmacy, Vietnam National University Hanoi, experts discussed the issue of sexually transmitted diseases (STDs), also known as sexually transmitted infections (STIs). These diseases primarily spread through sexual intercourse, including vaginal, anal, and oral sex, as well as non-sexual means such as blood transmission. Many dangerous sexually transmitted diseases can also be transmitted from mother to child during pregnancy and childbirth, such as syphilis, hepatitis B, HIV, chlamydia, gonorrhea, herpes, and HPV. According to the latest statistics from the World Health Organization (WHO), approximately 376 million cases of one of the four treatable STDs (chlamydia, gonorrhea, trichomoniasis, syphilis) occur each year, equating to over 1 million cases per day.
Experts also pointed out common symptoms of STDs, which include urethral discharge, genital ulcers, abdominal pain, vaginal discharge in females, or a burning sensation when urinating in males. However, there are also cases of STDs that present no clear symptoms. As a result, these syndromes often go undetected and untreated until complications arise. The agents of STDs are generally assessed to affect both men and women, but they tend to have more severe impacts on women, including infertility, ectopic pregnancy, chronic pain, cervical cancer, and other complications.
STD Testing - A Comprehensive Solution for the Health of the Transgender Community
The transgender community often faces a higher risk of sexually transmitted diseases (STDs). This partly stems from feelings of embarrassment and stigma, which can lead to hesitance in accessing healthcare and health education services. Additionally, society has not paid enough attention to the health issues faced by transgender individuals. Furthermore, the lifestyle of some in this community may result in a lack of protective measures, increasing the risk of STDs.
Screening, diagnosis, counseling, and early treatment can prevent the spread of STDs and minimize the complications of these diseases, with one of the most effective methods being STD testing. STD testing is a medical procedure aimed at detecting the presence of sexually transmitted diseases such as HIV, syphilis, gonorrhea, and chlamydia. If not treated promptly, these diseases can lead to serious complications, affecting both reproductive and overall health.
The importance of STD testing lies in its role in protecting individual and community health. First, early detection allows patients to receive timely treatment, reducing the risk of transmission to others. Second, regular testing helps individuals become aware of their health status, enabling them to make informed decisions regarding sexual relationships.
The advantages of STD testing include high accuracy and the ability to detect multiple types of diseases in a single test. Many testing methods today, such as blood tests, urine samples, vaginal swabs (for females), and urethral samples (for males), are easy to perform and painless. Additionally, privacy and confidentiality are ensured, allowing patients to feel comfortable during testing. Thanks to these benefits, STD testing is increasingly encouraged and plays a crucial role in community health care.
At GENTIS, STD testing can identify 12 pathogens, including: Chlamydia trachomatis; Ureaplasma parvum; Trichomonas vaginalis; Mycoplasma genitalium; Mycoplasma hominis; Neisseria gonorrhoeae; Ureaplasma urealyticum; Gardnerella vaginalis; Candida albicans; Treponema pallidum; Herpes simplex virus 1; and Herpes simplex virus 2. Sample collection can be performed by qualified gynecologists or self-collected using an HPV self-sampling kit. The samples are then analyzed using realtime-PCR technology to detect and quantify bacterial DNA in the samples with the PANA RealTyper™ STD kit (PANAGENE), which has received IVD certification. The process from sample collection to result delivery is quick and accurate, taking only 2-3 days. With two testing centers equipped with modern devices certified to ISO 15189:2022 standards, along with a team of experienced experts and technicians, GENTIS ensures that you and your loved ones will have the best experience.
GENTIS - A Partner for VNU 2024
As a sponsor of the conference, GENTIS is honored to provide information for the presentation by Assoc. Prof. Dr. Pham Xuan Da, Director of the High Medicine Center, University of Medicine and Pharmacy, Vietnam National University Hanoi, on the topic “The Status of LGBT, Transgender Needs, and Legal Aspects in Vietnam.”
Additionally, GENTIS made its mark at the VNU 2024 international scientific conference with a special booth where doctors, experts, and delegates could learn about STD testing services for the transgender community. The GENTIS booth also attracted attention with a lucky draw activity and many exciting prizes. Through this partnership, GENTIS aims to help everyone, especially the transgender community, raise awareness about sexual health and demonstrate its commitment to supporting the community.
The event not only emphasized the need to improve the quality of healthcare for transgender individuals but also created opportunities to connect leading experts in the field of sexual health from both domestic and international backgrounds. GENTIS is proud to be a part of this event and hopes that its medical efforts will support the community.
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The VNU 2024 is a valuable opportunity for medical professionals, scientists, managers in related fields to have a comprehensive and accurate perspective in sexual health, a new and crucial field. GENTIS is honored to accompany the conference with engaging activities namely: showcasing modern genetic testing ecosystems and organizing a lucky draw with appreciation gifts for attendees.
We cordially invited the esteemed delegates, professionals, and doctors to visit GENTIS’s broth at the international scientific symposium on new trends in sexual health 2024.
Date: September 14, 2024.
Location: Nguyen Van Dao Hall - Hanoi National University, 144 Xuan Thuy, Cau Giay, Hanoi.
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From the clinical perspective, Prof. PhD. MD. Nguyen Dinh Tao notes: “As technology advances, the desire to have healthy babies free from genetic diseases is justified. Today, there are numerous reproductive support and molecular genetic techniques available. Notable tests that provide social benefits for families desiring healthy babies include PGT-A and PGT-M.”
Prof. PhD. MD. Nguyen Dinh Tao, Chair of the Vietnam Morphological Society Scientific Conference 2024
Discussing eligible subjects for genetic testing before embryo transfer, Dr. Nguyen Ngoc Diep (Army Clinical Embryology Institute) states: “In general, apart from cases where parents carry disease genes, all couples wishing for children should undergo genetic testing before implantation to ensure healthy offspring. Additionally, those at high risk for chromosomal abnormalities or those with high risks of abnormal embryo development, such as older mothers (over 35), repeated miscarriages, or a history of implantation failures, should undergo PGT-A testing. However, cases with high chromosomal abnormalities despite parents not carrying disease genes should also consider genetic testing before implantation.”
In addition to basic PGT tests for pre-implantation genetic screening, couples can also consider two special PGT packages: PGT-Max 1 and One PGT-M.
“Both partners' reproductive health should be assessed simultaneously, including medical history, lifestyle, psychological factors, physical examination, and diagnostic tests. This helps in classifying patients based on various functional and morphological aspects, leading to differentiated treatment and diagnosis methods,” adds Associate Professor Nguyen Quang (Vietnam-Germany Friendship Hospital).
Assoc.Prof. PhD. MD. Nguyen Quang reports at the Vietnam Morphological Society Scientific Conference 2024
Assoc. Prof. Quang also emphasizes: “Genetic testing plays a crucial role in identifying the causes of infertility and reproductive support treatment. Tests such as Fertiscan (analyzing 120 genes for genetic causes of infertility in both genders), Karyotype (detecting chromosomal abnormalities), sex hormones (evaluating reproductive health), STDs (identifying common sexually transmitted pathogens), CFTR (detecting 22 CFTR gene mutations causing male infertility due to obstructive azoospermia or absent vas deferens) are essential.”
“We know that besides female infertility, male infertility is increasingly gaining attention. Genetic abnormalities are a common cause that significantly impacts reproductive health. To detect these abnormalities, besides clinical examination, genetic testing is crucial. Routine recommended tests include karyotyping and AZF microdeletion tests, especially for patients with sperm counts below 5,000,000/ml. Additionally, Fertiscan can screen for single-gene mutations related to male infertility,” adds Dr. Nguyen Ngoc Nhat (Army Clinical Embryology Institute).
Sharing clinical practice experiences in treating infertile couples, Assoc. Prof . PhD. MD Luong Thi Lan Anh notes: “Genetics and reproduction are closely linked. Utilizing technological advancements and combining various methods helps to address testing limitations, diversify disease coverage, and optimize cost and result turnaround time.”
Genetics is involved in nearly all aspects of reproductive support, including diagnosing genetic diseases, preventing them in future generations, diagnosing infertility causes, preventing recurrent miscarriages, and improving reproductive outcomes. The understanding of pathogenesis and scientific advancements have led to superior tests in reproductive support. GENTIS is proud to have the leading genetic testing center in Vietnam with advanced equipment. Notably, GENTIS is also the first institution in Vietnam to achieve international standards – ISO 15189:2022 and ISO 27001:2022, while adhering to strict Ministry of Health standards and international external quality control programs.
Currently, GENTIS offers comprehensive genetic testing to identify causes of infertility in both genders, screen for genetic abnormalities, prevent rare diseases in pre-implantation embryos, support embryo transfer, and monitor pregnancy. With advancements in genetics and reproductive support, GENTIS's genetic tests aim to assist infertile couples effectively, says Master Nguyen Thi Hue (GENTIS).
MSc. Nguyen Thi Huyen (GENTIS) reports at the Vietnam Morphological Society Scientific Conference
In reproductive support, genetic counseling has become more common, focusing on providing information about genetic disorders to patients, other health professionals, and the community. However, genetic counseling still faces challenges, including diagnostic issues, testing technology, result interpretation, counseling skills, and patient psychological support. Solutions involve enhancing knowledge, experience, and professional exchange among counselors, improving and developing testing technologies, and providing necessary psychological support for effective genetic counseling, says MSc. Nguyen Thi Huyen (GENTIS).
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Surpassing the council's evaluations, GENTIS, a genetic testing center, proudly won two awards: “Vietnam’s No. 1 Brand in Genetic Analysis” and “Best Product/Service for Consumers in 2024 for PGT-M Testing.”
GENTIS Wins “Vietnam’s No. 1 Brand in Genetic Analysis”
After over 13 years of development, this award serves as proof of GENTIS's service quality in the market and acknowledges the trust customers have in GENTIS. Participating in the Vietnam No. 1 Brand Award 2024 marks a significant step for GENTIS in establishing itself as a leading healthcare brand in the Vietnamese market and is a major milestone that propels GENTIS closer to the international market.
Genetic Analysis – GENTIS’s Pioneering Field
The award for “Vietnam’s No. 1 Brand in Genetic Analysis” recognizes GENTIS’s continuous efforts in pioneering modern genetic analysis technology, providing advanced and reliable solutions for customers. With a commitment to prioritizing quality and safety, GENTIS has firmly established its leadership in genetic analysis in Vietnam.
Genetic analysis is one of the advanced scientific fields today, helping to uncover information about genetic genes, providing insights into health, genetic disorders, and disease risk prediction. To ensure the accuracy and objectivity of genetic test results, along with investing in equipment, technology, and personnel, GENTIS places significant emphasis on building testing processes according to international standards and is accredited by global reputable organizations such as ISO 9001:2015, ISO 15189:2022, and ISO 27001:2022.
By applying modern technologies and adhering to domestic and international standards, GENTIS offers a range of genetic analysis services, from paternity testing, non-invasive prenatal screening, genetic counseling, to testing for rare genetic disorders. Each service is performed with high accuracy, adhering strictly to quality control processes to provide the most reliable and safe results for customers.
PGT-M Testing – GENTIS’s Commitment to Enhancing Reproductive Medicine
GENTIS’s PGT-M (Preimplantation Genetic Testing for Monogenic disorders) was also honored as the “Best Product/Service for Consumers in 2024.” This represents a significant advancement in supporting couples at risk of having children with monogenic genetic disorders. PGT-M helps prevent genetic disorders from parents to children, contributing to improving the quality of life and health for future generations.
At GENTIS, PGT-M testing is performed using state-of-the-art equipment and machinery, incorporating the latest NGS Illumina - USA gene sequencing system and the most advanced analytical software. Notably, the PGT-M testing process is rigorously constructed and executed to ensure the most reliable results.
GENTIS’s PGT-M Testing Recognized as the “Best Product/Service for Consumers in 2024”
Currently, PGT-M testing at GENTIS can screen for over 100 rare diseases, especially useful for couples with a family history of monogenic genetic disorders or those who have had children with genetic diseases or are carriers of disease-causing gene mutations. By screening and selecting embryos free of disease-causing genes, PGT-M helps reduce the risk of having a child with a disorder, thus enhancing the chance of having healthy children and alleviating the medical and emotional burden on families.
GENTIS is proud to be a pioneer in researching and developing PGT-M services in Vietnam. Not only providing highly accurate test results, GENTIS also brings together a team of experienced geneticists and top experts. Therefore, GENTIS is always ready to provide detailed genetic counseling to partners and customers. Additionally, GENTIS supports couples in understanding their health conditions and making the best decisions for themselves and their families.
Always Striving for the Benefit of Customers and Partners
Winning these two major awards is not only a source of pride for the entire GENTIS team but also a testament to the trust and support of customers in the company’s products and services. This will be a strong motivation for GENTIS to continue striving, continuously improving service quality, and providing optimal medical solutions to the community.
With the goal of delivering the best values to the community, GENTIS is continually working to improve technology, enhance service quality, and ensure the best benefits. The trust of customers and partners is the driving force for us to keep developing and affirming our position, deserving of the No. 1 brand award in genetic analysis in Vietnam.
The “Vietnam No. 1 Brand Awards 2024” marks a milestone recognizing GENTIS's contributions to the field of genetics and healthcare. We hope this will inspire GENTIS to continue its journey of enhancing service quality and brand reputation in the future.
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Currently, there are many factors that contribute to male infertility. However, according to Dr. Nguyen Ngoc Nhat (Institute of Clinical Morphology, Military Medical Academy), "Genetic abnormalities are among the most severe causes of male infertility." In reality, many reports indicate that genetic factors play a crucial role in reproductive function for both men and women. Dr. Nhat further explains: "Patients may encounter abnormalities at the chromosomal level, with Klinefelter syndrome being the most common. Deeper analysis may reveal structural chromosomal abnormalities or single-gene disorders such as Kallmann syndrome."
How to Identify Genetic Factors Related to Male Infertility
Many methods have been applied to diagnose and treat male infertility. To identify genetic factors associated with male infertility, Dr. Nguyen Ngoc Nhat shares: "The first step is to conduct an examination and screening of the patient to identify symptoms or clinical phenotypes. Then, determine the sperm density in the semen. If sperm density is below 10 million per milliliter, routine karyotype testing should be recommended. In cases where sperm density is below 5 million per milliliter, both karyotype testing and assessment for AZF microdeletions should be performed. For some single-gene disorders such as mutations causing Kallmann syndrome, specific gene sequencing tests are necessary."
In his report at the 19th IVF Experts Meeting held on August 9-10, 2024, in Hue, Dr. Nhat shared that during the examination and treatment of patients, he used AZF microdeletion testing to accurately determine the deleted regions on the long arm of the Y chromosome in patients.
Dr. Nhat also emphasized that GENTIS is a reputable and experienced institution in the field of genetic analysis. Notably, GENTIS's AZF testing detects many cases of chromosomal abnormalities and AZF microdeletions in clinical practice.
GENTIS proudly offers a comprehensive range of male fertility tests for over 30 reproductive support units nationwide. Compared to other providers, GENTIS consistently demonstrates superior technology and accuracy in AZF testing. Using specific DNA segment amplification by PCR combined with capillary electrophoresis, GENTIS ensures complete coverage of AZF regions, including AZFa, AZFb, AZFc, and AZFd. As a pioneer in genetic testing technology in Vietnam, GENTIS provides modern AZF testing with accurate results and rapid turnaround times. The AZF test prices at GENTIS are considered highly reasonable and competitive, making it accessible to all interested parties.
Honored to support and provide information for Dr. Nguyen Ngoc Nhat’s report at the IVF Experts Meeting, GENTIS hopes these contributions will assist clinical doctors in screening, diagnosing, and developing appropriate treatment protocols for patients.
With two testing centers equipped with modern facilities certified to ISO 15189:2022 standards, and a team of experienced specialists and technicians, GENTIS is committed to providing the best possible experience for you and your loved ones!
[content_more] => [meta_title] => Genetic Abnormalities in Male Infertility [meta_description] => Infertility is increasingly becoming a global issue, especially among men. According to the latest reports from the World Health Organization, approximately 1 in 6 people worldwide experience infertility, with male infertility accounting for up to 50% of [meta_keyword] => Genetic Abnormalities,Male Infertility,Gentis [thumbnail_alt] => [post_id] => 1240 [category_id] => 4 ) [7] => stdClass Object ( [id] => 1239 [id_crawler] => [category_product] => NULL [thumbnail] => 600x400-wweb-0.jpg [album] => [url_video] => [is_status] => 1 [is_featured] => 0 [is_form] => 0 [displayed_time] => 2024-08-20 [program] => 0 [number] => 1 [viewed] => 0 [type] => [type_career] => [level] => [address] => [address_career] => [expiration_time] => 0000-00-00 [created_time] => 2024-08-20 08:24:39 [updated_time] => 2024-09-16 09:28:53 [files] => [salary] => [time] => [created_by] => 63 [is_table_content] => 1 [language_code] => en [slug] => Gentis-accompanies-with-the-2024-annual-scientific-symposium-of-the-vietnam-mor-phological-society [title] => Gentis-accompanies-with-the-2024-annual-scientific-symposium-of-the-vietnam-mor-phological-society [description] => The XX Annual Scientific Conference of the Vietnam Morphological Society will take place from August 22-23, 2024, at Can Tho University of Medicine and Pharmacy. This year’s conference theme is “Training Models, Morphological Research, and Applications in the Digital Age,” promising to provide attendees with the latest updates from both domestic and international fields. The conference aims to offer valuable insights, enriching knowledge in the digital age, and practical skills for clinical practitioners related to morphology in general. [content] =>
Morphology plays a crucial role in the foundational and clinical training at medical universities across various specialties, including anatomy, pathology, medical genetics, histology, embryology, reproductive support, maxillofacial surgery, anthropometry, and anthropology. The teaching, research, and application of these specialties in morphology at medical schools nationwide are increasingly being promoted, contributing positively to the overall development of high-quality medical workforce training.
The XX Annual Scientific Conference of the Vietnam Morphological Society will feature an engaging program with presentations from leading experts, including:
The conference is expected to attract 300 delegates, including professors, doctors, and researchers working in fields such as anatomy, pathology, histology, embryology, reproductive support, maxillofacial surgery, genetics, anthropometry, plastic surgery, and anthropology from medical institutions and research centers both domestically and internationally.
GENTIS is honored to support this year’s conference as a sponsor and to contribute to various meaningful activities:
Additionally, the GENTIS booth will feature genetic testing consultations and host various games and a lucky draw with 100% prize-winning opportunities for delegates and doctors.
We cordially invite all delegates and doctors to join us!
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