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            [slug] => Discover-the-impressive-activities-that-gentis-will-bring-to-the-2024-VSSM-Conference
            [title] => Discover the impressive activities that GENTIS will bring to the 2024 VSSM Conference
            [description] => To update medical knowledge and enhance the professional capacity of doctors and medical staff nationwide, the Vietnam Society for Sexual Medicine (VSSM) and the General Hospital of Thanh Hoa are jointly organizing the National Scientific Conference of the Vietnam Society for Sexual Medicine – VSSM 2024 on June 7-8, 2024, at Dragon Style Hotel, Sam Son City, Thanh Hoa.


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This symposium serves as a forum for Vietnamese and foreign doctors to share experiences, exchange knowledge, and update the latest domestic and international developments in sexual and reproductive health care. This year, GENTIS is honored to accompany the VSSM 2024 Conference as a sponsor with many exciting activities.

Notably, GENTIS representative, Dr. Pham Dinh Minh, PhD. (Director of R&D) will present a report titled "Genetic Testing to Identify Abnormalities of Sexual Development and Basic Principles for Genetic Counseling" in session 4A: Reproductive Health and Sexual Function. In this report, Dr. Minh will share comprehensive genetic tests that meet the needs of identifying disorders of sexual development and assist clinicians in examination and treatment.
Additionally, GENTIS will feature a booth with impressive design and exciting programs such as a lucky wheel and mini-games. GENTIS will also offer many valuable appreciation gifts to doctors and delegates who visit the company’s booth.
We look forward to welcoming esteemed doctors and delegates at the VSSM 2024 Conference!

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            [meta_description] =>  the Vietnam Society for Sexual Medicine (VSSM) and the General Hospital of Thanh Hoa are jointly organizing the National Scientific Conference of the Vietnam Society for Sexual Medicine – VSSM 2024 on June 7-8, 2024, at Dragon Style Hotel, Sam Son City, 
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            [title] => GENTIS in the top 10 best poster presentations at 2024 ASPIRE conference
            [description] => ASPIRE is the largest and most prestigious annual conference specializing in assisted reproduction in the Asia-Pacific region. This year, the ASPIRE conference was held in Manila, Philippines from May 23 to 26, 2024. GENTIS is honored to participate in the ASPIRE conference with a poster report entitled "Clinical outcomes of embryo transfer based on morphological assessment combined with non-invasive preimplantation genetic testing (NIPGT): A study in Vietnam". (Clinical outcomes of embryo transfer based on morphological assessment combined with non-invasive preimplantation genetic testing (NIPGT): A study in Vietnam).

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The presentation of GENTIS was showcased in the 2024 ASPIRE conference
The conference attracted nearly 1,200 delegates who are experts in assisted reproduction in the region and around the world to attend. At the Conference, GENTIS shared an in-depth topical and scientific research in collaboration with Hanh Phuc International Hospital published in the form of a poster: "Clinical results of embryo transfer based on morphological evaluation combined with non-invasive preimplantation gene testing (NIPGT): A study in Vietnam".
The study evaluated clinical outcomes in two groups: IVF based on embryo morphological assessment alone (control group) and embryo selection group based on embryo morphological assessment combined with niPGT results (ASEM test). The results of the study showed that the proportion of children living in the control group and the study group was 38.6% and 41.1%, respectively. The results of the study also showed that the miscarriage rate in the study group was 0% (no miscarriages were recorded in the study group) and in the control group was 12.9%.
With the results of this initial study, niPGT has the potential to increase the birth rate, especially reduce the miscarriage rate. This is of great significance in helping patients not have to experience the physical and mental trauma of miscarriage. The topic is highly appreciated, very practical, attracting a lot of attention from colleagues in the region and around the world.
Notably, the GENTIS report was in the Top 10 best poster reports voted by the ASPIRE Scientific Council. This is a great honor and a motivation to help the product development department of GENTIS continue to research, innovate, create, and offer valuable tests to Vietnamese citizens.

Besides, it is within the framework of scientific research cooperation between Hanoi Hospital of Andrology and Infertility and GENTIS Company, Specialist level 1 Doctor Nguyen Thanh Trung reported at the hall on "Clinical outcomes of mosaic embryo transfer patients". The results of the study show that for patients who do not have diploid embryos for embryo transfer, embryo transfer with mosaic results can be considered. The report attracted the attention of a large number of delegates participating in the conference because the research results brought a lot of impressive information about the rate of implantation, miscarriage, and survived pregnancy when evaluating the clinical outcomes after mosaic embryo transfer.
The research team reported "Clinical outcomes of patients with mosaic embryo transfer"
Moreover, GENTIS is also very honored when the company's Fertiscan test is applied in practice by Dinh Huu Viet, MSc.MD. - Hanoi Hospital of Andrology and Infertility to find out the cause of genetic infertility in men, contributing to improving the effectiveness of diagnosis as well as counseling. treatment for infertile couples at the Hospital. Even more amazing is the results of the Fertiscan test of GENTIS at Hanoi Hospital of Andrology and Infertility which was published by Dr. Viet in the report "Genetic analysis results in patient with non-obstructive azoospermia" at the ASPIRE conference. The report attracted the attention of a large number of delegates in the hall.
Dinh Huu Viet, MSc.MD. - Hanoi Hospital of Andrology and Infertility presented the report "Results of genetic analysis of infertility in patients with unknown causes"
ASPIRE 2024 is one of many international conferences that GENTIS regularly attends and reports to colleagues and friends from countries around the world. This shows that GENTIS is a prestigious, professional and developed unit not only in Vietnam but also internationally.
Hoang Thi Nhung, MSc. (representative of GENTIS) and a team of doctors at Hanoi Hospital of Andrology and Infertility participated in the 2024 ASPIRE Conference
In addition to the development and improvement of the quality of testing services, scientific research is also one of the spearheads that GENTIS pays special attention to, making development efforts to improve professional capacity as well as update knowledge and practical application to bring success to patients in the cycle of in vitro fertilization.
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            [title] => Genetic counseling for rare disease prevention with Assoc. Prof. Tran Van Khoa
            [description] => On May 24, GENTIS Genetic Counseling Center successfully organized the Talkshow "Genetic counseling for the prevention of rare diseases and preimplantation testing PGT-M: Factors that determine the success and quality assurance of testing" with the participation of Assoc.Prof.Tran Van Khoa, PhD.MD. - Head of the Department of Biology - Genetics, Military Medical Academy, Nguyen Quang Vinh, MSc.  - Director of GENTIS Testing Center, Nguyen Thi Hue, MSc. - Genetic Consultant.

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MC and experts in the talk show "Genetic counseling for rare disease prevention and preimplantation testing PGT-M: Factors that determine the success and quality assurance of testing"
Currently, pre-screening tests of pre-implantation for monogenic diseases (PGT-M) are no longer strange in assisted reproduction and in vitro fertilization. PGT-M embryo screening combined with in vitro fertilization has become a lifeline method for many families who unfortunately carry the rare disease gene.
However, the application of PGT-M technique to screen embryos carrying rare monogenic diseases has not been implemented in many places. And if there are no screening strategies to prevent the transmission of diseases to the next generation, perhaps these diseases will no longer be "rare", but will be a problem in the community, affecting the quality of the population.
According to the European Union, a disease known as a rare disease has an incidence of less than 1 in 2000 people (per 2000 people). In the United States, a rare disease is defined as one that affects less than 200,000 Americans. 8 out of 10 rare diseases have genetic causes.
Genetic causes include monogenic pathologies, chromosomal pathologies, or extra-genetic pathologies. Therefore, not all rare diseases are genetic and not all genetic diseases are indicated for PGT-M.
The PGT-M test is currently indicated for monogenic diseases, based on the severity of the disease and considering whether the technical issue is feasible. Therefore, when indicating PGT-M testing, close coordination between clinicians, geneticists and genetic testing labs is needed to have the best indication.
Assoc.Prof.Tran Van Khoa, PhD.MD. shared extremely valuable knowledge in the talk show
During the talk show, Assoc.Prof.Tran Van Khoa, PhD.MD. shared extremely useful instructions on genetic counseling for clinicians and patients who need to prevent rare diseases. Associate Professor Khoa said: "One of the important points of the PGT-M test is to determine the cause of the disease. A clinically accurate diagnosis will help guide what type of test, what gene or group of genes to target, or which test technique to be able to detect the cause of the disease.
From those results, it will help the doctor a lot in the next steps to be able to conduct the PGT-M test. In addition, geneticists must also work with clinicians and embryologists to provide full information to infertile couples so that they can fully anticipate the limitations of the PGT-M test as well as the difficulties and challenges when screening embryos, embryo implantation, prenatal diagnosis,..."
In addition, Nguyen Thi Hue, MSc.  (Genetic Consultant at GENTIS Genetic Counseling Center) also pointed out the subjects who are recommended to take the PGT-M test. Specifically, those are couples who have given birth to children with monogenic diseases, families with a history of monogenic diseases, parents who are benign carriers of the same genetic disease, so they should perform the method of selecting embryos that do not carry the disease gene by pre-implantation genetic test (PGT-M) to select the best embryo in order to give birth to healthy babies.
Master Nguyen Quang Vinh (Director of GENTIS) also emphasized: "PGT-M is one of the most difficult tests in the field of assisted reproduction. PGT-M can help families give birth to babies who do not carry the disease gene or have inherited diseases from their parents. Since then, the number of disease genes in the human population will decrease day by day. GENTIS has been performing PGT-M tests since 2017 and is currently researching and deploying more than 100 monogenous genetic diseases.
At GENTIS, PGT-M testing is performed in an ISO-compliant laboratory by NGS, Sanger or PCR gene sequencing methods by skilled technicians and experienced analysts. After that, the genetic consultant will make a final conclusion and send it to the clinician to advise the patient, thereby transferring the embryo without carrying the disease gene into the mother's uterus."
Experts have shared, multi-dimensional perspectives, positive opinions, solved the questions of the audience and created an attraction for the Talkshow
With the desire to help infertile couples give birth to healthy babies, GENTIS always invests in the most modern equipment in the world and researches and develops PGT-M tests for rare diseases to support clinicians in the treatment of infertility.
Based on that desire, the Talkshow "Genetic counseling for rare disease prevention and pre-implantation testing of PGT-M: Factors that determine the success and quality assurance of testing" was organized, in order to provide intuitive and easy-to-understand knowledge, helping couples always be confident on the journey of "finding a child".
Hopefully, the sharing, multi-dimensional perspectives, and practical experiences of Assoc.Prof.Tran Van Khoa, PhD.MD., Nguyen Quang Vinh, MSc. and Nguyen Thi Hue, MSc. have helped unfortunate couples  carrying rare disease genes to have more energy and confidence on the journey to find healthy "little angels". 
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            [title] => GENTIS Introduces Expanded Thalassemia Testing Package at Lac Viet Friendship Hospital
            [description] => On the afternoon of May 22nd, with the aim of enhancing the professional knowledge and updating the latest advancements in the diagnosis and treatment of thalassemia for medical professionals at Lac Viet Friendship Hospital, GENTIS collaborated with the hospital to organize a workshop introducing the expanded thalassemia testing. This meaningful event aimed to help healthcare providers understand the importance of thalassemia screening and take practical actions to effectively prevent this genetic disease.

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The program was attended by Dr. Nguyen Ngoc Anh, Head of the IVF Department, and more than 15 nurses, doctors, and embryologists specializing in assisted reproduction at Lac Viet Friendship Hospital. Representing GENTIS were Nguyen Thi Hue, MSc.,MD. and Nguyen Thi Huyen, MSc.,MD., R&D Specialist and Genetic Consultant.
At the workshop, Dr. Hue (GENTIS) presented a detailed overview of thalassemia and the latest advancements in genetic testing. Dr. Hue explained that thalassemia is an autosomal recessive genetic disorder related to hemoglobin abnormalities. Specifically, it involves the partial or complete reduction in the production of globin chains, resulting in the defective synthesis of one or more globin chains. Thalassemia types are classified and named based on the affected globin chain, with alpha thalassemia and beta thalassemia being the most common clinical presentations.

Vietnam is one of the countries with the highest prevalence of thalassemia gene carriers in the world, with approximately 14 million individuals carrying the gene. People with the disease and carriers can be found in all provinces and cities, across all ethnic groups nationwide.
Notably, thalassemia has imposed a significant burden on the health, mental well-being, and finances of patients and their families. This disease is a social issue that severely impacts the economy, quality of life, and future generations.
However, thalassemia can be effectively prevented through simple and affordable genetic screening tests. Therefore, young people and those of reproductive age, regardless of their location or ethnicity, should undergo thalassemia genetic testing to prevent the birth of affected children.
Currently, thalassemia diagnosis can be performed at many hospitals and testing centers, including GENTIS. Dr. Hue shared, "At GENTIS, we utilize the most advanced testing methods to enhance the efficiency of our tests. Sample collection is performed by experienced technicians. If the test results indicate that the patient carries the thalassemia gene, GENTIS's team of genetic counselors will provide personalized advice to improve the quality of treatment."
Understanding the importance of thalassemia testing in controlling, treating, and preventing the disease for future generations, GENTIS has launched an expanded thalassemia testing package.
Specifically, this test can detect 5 mutations related to alpha thalassemia: -αSEA, -α3.7, -α4.2, CS, and QS, and over 800 mutations located in the coding region of the HBB gene that have been reported in databases related to beta thalassemia and hemoglobinopathies, including 16 common mutations such as CD41/42, CD43, IVS-II-654, -28, -29, CD71/72, CD26, CD17, CD14/15, CD27/28, CAP, Int, IVS-I-1(G-T), IVS-I-1(G-A), IVS-I-5, and CD31. Other mutations include point mutations, deletions, and short insertions (less than 4 nucleotides) in the coding region and nearby introns (-10/+10 nucleotides from the exon) of the HBB gene. A negative result does not exclude the possibility of the sample carrying additional deletions or insertions larger than 4 nucleotides.

With the goal of increasing the success rate of infertility treatment and helping couples having healthy babies, GENTIS has applied the latest technologies and personalized treatment protocols to achieve optimal outcomes. Accordingly, PGT-M-Thalassemia testing at GENTIS allows doctors to identify the genetic information of embryos and select embryos that do not carry the disease before embryo transfer. This technique helps prevent the transmission of genetic diseases and reduces the rate of pregnancy termination due to genetic disorders, including thalassemia.


Following Dr. Hue's presentation, the hospital's physicians engaged in a lively question-and-answer session related to thalassemia testing. Dr. Ngoc Anh expressed particular interest in the expanded thalassemia testing package. In response to Dr. Nguyen's inquiry, Dr. Huyen (GENTIS) explained that at GENTIS, the expanded thalassemia testing package is performed using whole-exon amplification of the HBB gene and sequencing on a US-based NGS system, achieving an accuracy of up to 99%. Furthermore, GENTIS has a team of genetic counselors who provide pre-, during, and post-test counseling to support clinicians in developing the best monitoring and treatment strategies for patients.
Hopefully after this workshop, GENTIS and Lac Viet Friendship Hospital will further develop their collaboration for mutual benefits.
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            [title] => GENTIS & Hanoi Hospital of Andrology and Infertility: Lighting Up the Dreams of Infertile Families
            [description] => On the morning of May 19, 2024, the Hanoi Andrology and Infertility Hospital successfully held the Closing Ceremony for the 2024 Golden Week Program and the 15th Anniversary (2009 – 2024) with the theme: "Lighting Up the Dreams of Infertile Families.”


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GENTIS is honored to be the main sponsor of the program, accompanying the hospital in spreading humanitarian values and sharing love with the infertile community, along with meaningful reunions of hundreds of couples who have successfully undergone assisted reproductive treatments at the hospital.

The program was organized with thousands of guests attending, including Prof. Nguyen Dinh Tao, PhD.MD. – President of Hanoi Society of Assisted Reproduction; Assoc.Prof.Nguyen Quang, PhD. – President of Vietnam Society for Sexual Medicine;... and the leadership of Hanoi Andrology and Infertility Hospital: Mr. Le Trung Hieu – Chairman of the Board of Directors, Le Thi Thu Hien, MSc.MD. – Medical Director, Specialist level 1 Pham Van Huong, MD. – Deputy Medical Director and Head of the Assisted Reproduction Department;... among many other infertile couples from across the country.

At the opening of the ceremony, Mr. Nguyen Van Cuong – Executive Director of the hospital, said, "With the core values of 'Dedication – Trust – Quality' embedded in all our activities, the hospital has successfully performed tens of thousands of IVF cycles with a high success rate. Alongside professional development, the hospital continuously strives to improve services, invest in modern equipment, and optimize treatment effectiveness to provide international-standard service experiences at an affordable cost for the majority of the population."

The year 2024 marks the 10th year of the “Golden Week” program. The positive response and support from the community have motivated the hospital to continue implementing it over the years. Since 2015, thousands of couples have received support from the “Golden Week” program of Hanoi Andrology and Infertility Hospital, with over 50 disadvantaged families receiving 100% IVF financial aid, resulting in the birth of 59 babies; more than 400 cases of free services through file review with a total support value of billions of VND; nearly 600 lucky support packages worth from 5 to 100 million VND.

Le Thi Thu Hien, MSc.MD. - Medical Director of the hospital said: “… We are truly happy because the Golden Week not only brings humanitarian values to the community but also serves as a bridge for everyone to understand and share with infertile families longing for children, breaking down psychological barriers, social prejudices, and spreading love in the community.”
This year, the program took place over two weeks, from May 6 to May 19, 2024. To celebrate the hospital’s 15th anniversary, the "Golden Week 2024" increased the number of support packages covering 100% of IVF costs from 10 to 15 cases, through a file approval process. Additionally, the program offered 105 other fully funded cases, creating a humanitarian journey, a unique mark of AF HANOI, helping thousands of infertile families across the country.

The desire to have children always lingers and creates an invisible pressure on infertile couples. Many families turn to methods such as in vitro fertilization or artificial insemination, but fail multiple times due to carrying genetic disorders like hemophilia, spinal muscular atrophy, etc. Understanding these hardships and desiring to assist families on their journey to parenthood, GENTIS has joined this major event as the main sponsor, providing various forms of support.
Sharing about the program, Mr. Do Manh Ha – CEO of GENTIS, expressed his great honor in partnering with it. This is an incredibly meaningful program aimed at helping infertile couples on their journey to have children. He hopes that GENTIS will always be a long-term companion with the hospital to contribute to supporting difficult and infertile families and turning the dream of parenthood into reality. 
In the future, GENTIS promises to continuously strive, update, and develop more research and tests to best serve infertile couples, working together to achieve the sacred dream for all families across the country.

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            [title] => GENTIS participated in the launch ceremony of the "DFT 1:1 Model - Optimizing IVF Success Rates" at Phuong Dong General Hospital
            [description] => The launch of the "DFT 1:1 Model - Optimizing IVF Success Rates" on May 18, 2024, is considered the biggest assisted productive event of the year hosted by High-Tech Center of Infertility and Andrology of Phuong Dong General Hospital.

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With a growing desire to help more families realize their dream of parenthood, the launch ceremony of the DFT 1:1 Model - Optimizing IVF Success Rates was held. This event provided an opportunity for aspiring parents to gain knowledge, receive direct consultation from doctors, and feel more prepared to welcome their baby successfully.

The launch ceremony was graced by the presence of Assoc. Prof. Nguyen Trung Chinh, MD., Director of Phuong Dong General Hospital, and Distinguished Physician, Specialist level II doctor Han Van Ba, Deputy Director of Phuong Dong General Hospital, along with numerous doctors, guests, and over 100 couples struggling with infertility.
As the main sponsor, GENTIS had the honor of introducing to doctors, experts, and IVF patients advanced testing packages that significantly contribute to assisted reproductive progress.
Within the framework of the launch ceremony, a panel discussion titled "Optimizing IVF Success Rates" brought together experts in assisted reproduction to share valuable insights and knowledge with couples seeking fertility treatment.

Notably, Nguyen Quang Vinh, MSc., Director of GENTIS Testing Center, provided detailed information on the advantages of embryo screening tests, including the detection of single-gene genetic disorders, chromosomal structural rearrangements, chromosomal number abnormalities, etc.

M.S. Vinh shared an overview of preimplantation genetic testing (PGT) and its significant role in increasing IVF success rates.

He particularly emphasized PGT-Max 1, an upgraded version of PGTest with high resolution, capable of detecting common microdeletions larger than 2Mb associated with DiGeorge Syndrome and 1p36 deletion.
As a leading pioneer in genetic analysis in Vietnam, GENTIS is committed to bringing the world's most advanced testing services and packages to our clients and partners, with the goal of enhancing the physical and intellectual well-being of Vietnamese people. Congratulations once again on the successful launch event.
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            [slug] => Gentis-service-introduction-workshop-at-hong-ngoc-phuc-truong-minh-ivf-center
            [title] => GENTIS Service Introduction Workshop at Hong Ngoc Phuc Truong Minh IVF Center
            [description] => On May 14th, 2024, GENTIS, in collaboration with Hong Ngoc Phuc Truong Minh Hospital's IVF Center, successfully conducted a workshop introducing the "Expanded Thalassemia Testing Package" to the center's medical staff.


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With the goal of collaborating and conducting in-depth research on various testing services to support assisted reproduction, GENTIS organized a workshop introducing the "Expanded Thalassemia Testing Package" at Hong Ngoc Phuc Truong Minh Hospital's IVF Center. The workshop was attended by MSc. Hoang Thi Thuan, Head of the IVF Lab at Hong Ngoc Hospital, and over 15 medical professionals from the hospital.
The workshop was attended by the medical staff of Hong Ngọc Hospital.
Representing GENTIS, Nguyen Thi Huyen, MD.MSc. -  a senior researcher and genetic consultant at GENTIS Genetic Counseling Center, participated in the workshop.
At the workshop, Nguyen Thi Huyen, MD.MSc. presented a detailed report on the expanded thalassemia testing package developed by GENTIS.
Ms. Nguyen Thi Huyen began the workshop by providing a detailed explanation of the pathogenesis of hemoglobinopathies and common thalassemia mutations in the Vietnamese population.
Dr. Nguyen Thi Huyen provided a detailed presentation on Thalassemia.
Thalassemia is the most common single-gene genetic disorder in the world. According to a 2008 report by the Thalassemia International Federation and WHO, an estimated 7% of the global population carries the thalassemia gene, and over 330,000 children are born with severe forms of the disease each year.
In Vietnam, the prevalence of the thalassemia gene is estimated to be as high as 12%, with over 12 million carriers. Thalassemia affects people from all provinces and ethnic groups across the country. Currently, there are over 20,000 people living with thalassemia and requiring lifelong treatment, and approximately 8,000 new cases are diagnosed each year, including around 2,000 severe cases and 800 fetal deaths due to fetal hydrops. (According to statistics from the Vietnam Thalassemia Association)
In order to help gene carriers be proactive in controlling and preventing Thalassemia, especially Thalassemia major as well as building a healthy community, GENTIS launches an expanded Thalassemia testing package to help detect mutations related to alpha thalassemia and beta thalassemia.
Mutations detected:

The most common five mutations causing alpha thalassemia (-αSEA, -α3.7, -α4.2, -CS, QS) 
Over 800 mutations in the coding region of the HBB gene, including 16 common mutations (CD41/42, CD43, IVS-II-654, -28, -29, CD71/72, CD26, CD17, CD14/15, CD27/28, Cap, Int, IVS-I-1(G-T), IVS-I-1(G-A), IVS-I-5, CD31), have been reported in databases related to beta thalassemia and hemoglobinopathies. Other mutations include point mutations, deletions, and short insertions (less than 4 nucleotides) in the coding region and nearby introns (-10/+10 nucleotides from the exon) of the HBB gene.

The information about the testing package generated significant interest among the attending physicians.
The doctors showed great interest in the content of the testing package.
In response to MSc. Hoang Thi Thuan's question about the percentage of detected mutations compared to the total number of reported mutations, Ms. Nguyen Thi Huyen stated that:
“The mutations detected by GENTIS's expanded thalassemia testing package account for 97-98% of all thalassemia carriers. Additionally, GENTIS is currently researching and refining the process to develop a test that can detect even more alpha thalassemia mutations.”
The medical team's inquiries received comprehensive and specific advice.
Moreover, Dr. Huyen provided detailed and clear answers to all the questions raised by the medical team. GENTIS's expanded thalassemia testing package is an advanced test that utilizes Illumina's next-generation sequencing (NGS) technology to enhance the detection of rare mutations that are not included in traditional testing packages. The doctors unanimously agreed that this testing package is a valuable tool for both clinicians and patients in screening for this dangerous genetic disease.

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            [meta_description] => On May 14th, 2024, GENTIS, in collaboration with Hong Ngoc Phuc Truong Minh Hospital's IVF Center, successfully conducted a workshop introducing the "Expanded Thalassemia Testing Package" to the center's medical staff.


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            [title] => GENTIS Launches Expanded Thalassemia Test Package
            [description] => As a pioneer in the field of genetic analysis, especially the application of genetic tests in hematology, GENTIS has always strived to improve and launch an expanded thalassemia test package to effectively support doctors in diagnosis, treatment, and genetic counseling for patients with this disease.

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Thalassemia (congenital hemolysis) is the world's most common monogenic disorder. It is estimated that in the world, about 7% of the population currently carries the disease gene, over 330,000 children born annually suffer from the disease. In Vietnam, according to a report by the National Institute of Hematology and Blood Transfusion, all 63 provinces/cities and 54 ethnic groups have people carrying the disease gene. The numbers on the situation of congenital hemolytic disease in Vietnam are really alarming. It is estimated that about 14 million people carry the disease gene across the country (accounting for about 13%).

You should take an expanded thalassemia test for health screening today
According to statistics from the Vietnam Congenital Hemolysis Association, there are more than 20,000 patients who need treatment, of which 44% are children (<15 years old). Currently, more than 20,000 people with thalassemia need lifelong treatment and about 8,000 more children are born with thalassemia annually, of which about 2,000 are severely ill and about 800 cannot be born due to hydrops fetalis.
In addition, thalassemia is also a genetic disease with the highest incidence, a severe prognosis and requires large treatment costs. In fact, it also shows that the cost to prevent thalassemia is much smaller than the cost of treatment with outstanding efficiency.
Therefore, screening for thalassemia is necessary for everyone, especially those with a family history of the disease, which should be done right from the premarital stage. In case the couple unfortunately carries the disease gene, the doctor should advise on healthy childbirth measures to move towards ending the situation of the child being born with the disease and gradually reducing the inheritance rate of the disease gene in the community.
In order to help disease gene carriers be proactive in controlling and preventing thalassemia, especially severe thalassemia as well as building a healthy community, GENTIS has launched an expanded thalassemia test package to help detect gene mutations related to alpha thalassemia and beta thalassemia.
Screening Scope:

Detection of the 5 most common mutations that cause alpha thalassemia: -αSEA; -α3.7; - α4.2; -CS; QS.
Detection of more than 800 mutations located on the coding region of the HBB gene has been reported on databases related to beta thalassemia and hemoglobin disease, including 16 common mutations including CD41/42, CD43, IVS-II-654, -28, -29, CD71/72, CD26, CD17, CD14/15, CD27/28, Cap, Int, IVS-I-1(G-T), IVS-I-1(G-A), IVS-I-5, CD31. Other mutations include spot mutations, deletions, and short segment insertions (less than 4 nucleotides) in the coding region and neighboring introns (-10/+10 nucleotides from exons) of the HBB gene.

Note: A negative result does not exclude samples carrying duplication/deletion mutations or intels greater than 4 nucleotides.
At GENTIS, the expanded thalassemia test uses Illumina's NGS next-generation gene sequencing technology to enhance the specificity, sensitivity, and accuracy of the test. This is a technique that is considered the gold standard because it will help determine exactly whether you carry the alpha thalassemia or beta thalassemia gene. From there, it supports doctors in diagnosing and treating diseases effectively and providing reasonable reproductive advice.
In addition to the expanded thalassemia test package, GENTIS is currently providing 3 thalassemia test packages to help reduce the burden on many families, as well as society and have suitable options for the next generation to be healthy:

β-Thalassemia Test Package: Find 16 β-Thalassemia mutations with high sensitivity and specificity using Sanger sequencing technology.
Thalassemia 21 Mutation Test Package: Using a commercial kit with CE-IVD certification with high accuracy, 21 α and globin β mutations were detected in Vietnamese population.
PGT-M Thalassemia Test: Pre-implantation test for Thalassemia.

In order to serve customers with advanced tests, GENTIS always invests in complete, modern facilities, ready for research as well as product improvement. Not only that, GENTIS is also proud to own a team of highly qualified, skilled staffs who are passionate and knowledgeable about technological and technical advances and constantly updating new knowledge of the industry in the world. In particular, GENTIS always has a Scientific Council with experts who are experienced researchers to "increasingly improve the physical and intellectual quality of Vietnamese people".

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