PGT UPGRADE

PGT UPGRADE is a preimplantation genetic testing (PGT) method designed to detect aneuploidies across all 24 chromosomes, structural abnormalities (additions or deletions), and embryos carrying balanced translocations inherited from parents. This test provides essential genetic information to support embryo selection before transfer.

• Performing the UPGRADE PGT test can detect aneuploidy on 24 chromosomes → Helps screen and eliminate embryos with abnormal chromosome numbers before transfer.
• Detecting chromosomal additions/deletions helps avoid the risk of giving birth to children with birth defects or genetic syndromes due to chromosomal structural abnormalities.
• Identify embryos carrying balanced translocations (inherited from the father/mother) → Helps couples carrying balanced translocations avoid the risk of giving birth to children with chromosomal imbalances, leading to birth defects or developmental delays.
• Reduce the risk of consecutive miscarriages, implantation failure due to chromosomal abnormalities → Supports couples with a history of miscarriages, multiple IVF failures.
• Increase the chance of giving birth to healthy children with normal chromosomes → Especially important for couples with a family history of genetic disorders related to chromosomes.

- Detects embryos carrying balanced translocations inherited from parents.

- Utilizes specialized bioinformatics software optimized for the Vietnamese population to analyze sequencing results.

- Couples where one partner carries a balanced translocation and wishes to prevent passing it to the next generation.

- Women over 35 years old.

- Repeated implantation failure.

- Severe male factor infertility.

- Couples with a history of recurrent miscarriage.

- Families with a history of chromosomal abnormalities.

- Parental samples: 2-3 mL of whole blood (collected in EDTA anticoagulant tubes) along with balanced translocation test results.

- Day 5 embryo biopsy sample.

Step 1: Embryo biopsy

Step 2: Perform NGS “Low pass sequencing”

Step 3: Combine whole genome sequencing NGS (Low pass sequencing) with targeted SNP sequencing to detect embryos carrying balanced translocations

- DNA extraction from embryo cells.

- Whole-genome amplification, library preparation, and sequencing using Next-Generation Sequencing (NGS) technology (Illumina).

- Data analysis using specialized bioinformatics software optimized for the Vietnamese population.

12 – 14 days

- Two high-standard laboratories in Hanoi and Ho Chi Minh City.

- Certified with ISO 9001:2015 & ISO 15189:2022.

- State-of-the-art technology, among the most advanced in Asia.

- Experienced team of genetic experts and doctors.