Specialized news

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            [slug] => https://gentis.com.vn/tin-tuc-c4/gentis-ra-mat-2-goi-xet-nghiem-phan-tich-di-truyen-truoc-chuyen-phoi-moi-pgt-next-va-pgt-upgrade-d1280
            [title] => GENTIS launches 2 new test packages: PGT NEXT and PGT UPGRADE
            [description] => With the pioneering advantage in applying genetic and genetic testing in assisted reproduction, GENTIS constantly strives to improve and launch new expanded pre-implantation genetic testing packages: PGT NEXT and PGT UPGRADE. These are two superior in-depth integrated tests with many outstanding advantages.
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PGT NEXT
PGT NEXT is a pre-implantation genetic analysis test that can detect aneuploidy on 24 chromosomes, chromosomal abnormalities, and chromosomal deletions. It can also detect embryos with polyploidy or haploidy. This helps avoid transferring polyploid/haploidy abnormal embryos, and avoid wasting euploid embryos with fertilization abnormalities (0PN, 1PN, and 2.1/3PN). In addition, the PGT NEXT test also supports the provision of genetic information for embryo selection before embryo transfer. The combination of NGS whole genome sequencing with SNP analysis improves the resolution of genetic screening for polyploidy.This method allows for the identification of haploid and polyploid chromosome sets, increasing the number of healthy euploid embryos available for transfer by accurately detecting true diploid embryos among abnormally fertilized embryos (0PN, 1PN, 2.1PN, 3PN). Additionally, SNP analysis ensures precise identification of whether the tested embryo is genetically related to other embryos in the same cohort, thereby reducing the risk of sample mix-ups due to procedural or handling errors.


 Detection range:

- Aneuploidy of all 24 chromosomes
- Chromosomal structural abnormalities (addition, deletion)
- Detection of embryos with polyploidy or haploid abnormalities.

 Method: Whole genome sequencing and target marker sequencing on next-generation sequencing machine NGS.
 Sample used: Day 5 embryo biopsy sample
 Time to return results: 3 – 4 weeks

PGT UPGRADE
PGT UPGRADE is a pre-implantation genetic analysis test that can detect aneuploidy on 24 chromosomes, additional abnormalities, chromosomal deletions with a size of over 5 Mb, especially capable of detecting embryos carrying balanced translocations inherited from the parents. Chromosomal translocations are structural abnormalities of chromosomes caused by the rearrangement of large segments between non-homologous chromosomes. There are two types of translocations: balanced (no loss of genetic material) and unbalanced (loss or extra genetic material, such as aneuploidy). When both the father and mother carry balanced translocations, approximately 60% of gametes will carry unbalanced translocations, leading to embryos with chromosomal abnormalities. This is also a common cause of repeated implantation failure, recurrent miscarriage, and birth defects. PGT UPGRADE test helps to select euploid embryos for parents carrying balanced translocations to increase the chance of having a healthy baby. In addition, PGT UPGRADE also supports providing genetic information for the embryo selection process before embryo transfer.
Performing PGTest testing can select genetically good quality embryos to increase the chance of pregnancy when performing in vitro fertilization (IVF), helping to increase the chance of the child being born healthy, without the screened genetic abnormalities.


 Detection range:

- Aneuploidy of all 24 chromosomes
- Chromosomal structural abnormalities (addition, deletion) larger than 5 Mb
- Detection of embryos carrying balanced genetic translocations inherited from parents

 Method: Next generation sequencing NGS (Illumina) and analysis of sequencing results using specialized bioinformatics software
 Samples used:

- Parental samples (2-3 ml whole blood in EDTA anticoagulant tubes) and balanced translocation test results.
- Day 5 embryo biopsy sample

 Time to return results: 12 - 14 days

Meaning of PGT NEXT and PGT UPGRADE tests
Preimplantation Genetic Testing (PGT) is a specialized technique to identify genetic abnormalities in embryos created through in vitro fertilization (IVF/ICSI). Preimplantation genetic testing offers the following benefits:
Detecting genetic abnormalities in embryos
PGT helps identify abnormalities in chromosome number (PGT-A) or specific gene mutations (PGT-M), thereby reducing the risk of passing on genetic diseases to the next generation.
Increase IVF success rate
Selecting healthy embryos with normal genes improves implantation rates, increases the chance of pregnancy, and reduces the risk of miscarriage.
Support for optimal embryo selection
Ensuring that only embryos that do not carry genetic diseases or genetic abnormalities are transferred into the uterus increases the chances of having a healthy baby.
Advanced and modern technology
Illumina's next-generation sequencing technology (NGS) with >99% accuracy on target markers and specialized bioinformatics software is the technological standard for PGT testing, increasing the accuracy and sensitivity of the test.
Currently, preimplantation genetic testing (PGT) packages can be performed at a number of hospitals and reproductive support centers in Vietnam. Among them, GENTIS is a pioneer in performing PGT testing packages accurately and professionally.
In particular, GENTIS has a system of high-tech machinery and a team of experienced professionals, where infertile couples put their trust when performing difficult tests. Before doing the screening test, customers will be given genetic counseling and detailed information about the test. Through PGT testing packages, GENTIS hopes to support doctors and infertile couples to quickly find their beloved children, as well as give birth to healthy children, bringing happiness to families nationwide.
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            [slug] => Breakthroughs-in-the-application-of-genetic-testing-in-reproductive-medicine-worldwide-and-in-Vietnam
            [title] => Breakthroughs in the Application of Genetic Testing in Reproductive Medicine Worldwide and in Vietnam
            [description] => During her visit and work in Vietnam, Assoc. Prof. Dr. Francesca Spinella (Senior Medical Information Specialist at Eurofins Genoma Group, Former President of ESHRE PGT Consortium) expressed her admiration for the remarkable advancements made by genetic testing laboratories in the diagnosis and treatment within the field of reproductive medicine. In particular, she praised GENTIS for both its professional expertise and state-of-the-art facilities. She mentioned that the collaboration between GENTIS and GENOMA will enhance multi-level development among global healthcare organizations, particularly in the area of genetic testing.
            [content] => 
Genetic Breakthroughs in Preimplantation Genetic Testing Being Applied in Europe and Vietnam
Assoc. Prof. Dr. Francesca Spinella explained that there are currently three widely used preimplantation genetic testing techniques being applied across Europe and globally: PGT-A, PGT-SR, and PGT-M. These primary methods help improve the success rates of in vitro fertilization (IVF) while reducing the risk of serious genetic disorders in future generations.
Among these, PGT-A helps detect chromosomal aneuploidy to screen out embryos that have abnormalities. This method has been proven to increase IVF success rates, decrease miscarriage rates, and ensure that the embryos implanted are the healthiest.
PGT-M is used to detect genetic mutations that could be inherited from parents, helping to avoid passing on common monogenic disorders like thalassemia, cystic fibrosis, Huntington's disease, and other genetic conditions. PGT-SR can detect structural chromosome abnormalities such as translocations, inversions, or deletions. These abnormalities can cause pregnancy complications and increase the risk of giving birth to a child with birth defects.
In addition to the widely implemented techniques, Assoc. Prof. Dr. Francesca Spinella mentioned two promising new methods that are being researched and developed in Europe: Non-invasive PGT-A (NiPGT-A) and PGT for ploidy (Ploidy). These breakthroughs are driven by the rapid development of genetic sequencing technologies, opening new possibilities for reproductive healthcare.
NiPGT-A represents a breakthrough in preimplantation genetic testing, allowing for testing without the need for embryo biopsy, thus minimizing potential risks to the embryo. This method detects chromosomal abnormalities in embryos from the culture medium, providing greater convenience and safety. Meanwhile, PGT for ploidy (Ploidy) is an advanced test that accurately determines the number of chromosomes in the embryo, helping to select embryos with a complete chromosomal set, thereby reducing the risk of reproductive issues or birth defects.
Assoc Prof. Dr. Francesca Spinella also expressed her deep impression with the preimplantation genetic testing methods being used in Vietnam. She stated that the expertise and modern facilities of the labs, especially at GENTIS, are on par with leading genetic testing centers worldwide.
Assoc Prof. Dr. Francesca Spinella Visits and Works at GENTIS Lab
In addition to common tests like PGT-A, PGT-M, and PGT-SR, GENTIS is also focusing on researching and developing two breakthrough techniques: PGT-Next and PGT-Upgrade. PGT-Next is an advanced method that combines the features of both PGT-A and PGT-SR, with the added capability of detecting chromosomal number abnormalities such as polyploidy and haploidy in embryos. This improves diagnostic accuracy, minimizes the risk of pregnancy with embryos that have chromosomal abnormalities, and optimizes the chances of a healthy pregnancy.
PGT-Upgrade is a significant advancement in genetic diagnosis of embryos. In addition to detecting abnormalities in chromosome number (PGT-A) and structure (PGT-SR), PGT-Upgrade can identify balanced chromosomal translocations passed from parents to embryos. This method helps detect hidden risks that PGT-A and PGT-SR cannot diagnose, while also identifying genetic factors that could affect the health of future generations. PGT-Upgrade offers superior advantages in selecting healthy embryos for artificial reproduction, thereby improving IVF success rates.
Strengthening Relationships and Promoting Multilateral Cooperation Among Global Healthcare Organizations
Promising Collaboration Between GENTIS and GENOMA
Through her visit and discussions, Assoc. Prof. Dr. Francesca Spinella noted that Vietnam’s healthcare services, particularly in reproductive medicine, have significant potential for growth. She emphasized that this event not only provided an opportunity to exchange ideas on advancements in genetic testing but also served as a clear testament to the sustainable and strategic partnership between GENTIS and GENOMA, both members of the Eurofins family. The cooperation between GENTIS and GENOMA is not based solely on commercial interests but also on the shared commitment to scientific research and advanced technologies. Both organizations share values in improving reproductive health and providing accurate and reliable genetic testing services for families and healthcare professionals in their reproductive health journeys.
This collaboration also allows GENTIS to access the latest genetic testing technologies and implement them in Vietnam, enhancing the quality of reproductive healthcare services domestically and contributing to the development of the genetic testing industry in Southeast Asia. GENTIS’s clients will now benefit from advanced genetic testing services, which offer the opportunity for healthy childbirth and minimize risks during pregnancy.

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            [title] => Learning About New Genetic Tests in Reproductive Support Worldwide and Their Practical Application in Europe with Assoc. Prof. Dr. Francesca Spinella
            [description] => With the goal of updating knowledge to enhance the effectiveness of medical examination and treatment, as well as to introduce reproductive support techniques being applied in Europe, the GENTIS Genetic Counseling Center successfully organized the 5th edition of the Genetic Counseling Talkshow - Discussion with Experts. The theme was “Application of New Genetic and Genomic Testing in Reproductive Support Worldwide and Their Practical Use in Europe.” GENTIS was honored to have Assoc. Prof. Dr. Francesca Spinella (Senior Medical Information Specialist of Eurofins Genoma Group, Former Chair of the ESHRE PGT Consortium) and Dr. ThS. BSNT Đinh Thị Quỳnh Ngọc (GENTIS Genetic Counseling Center) as speakers. The program attracted widespread attention from doctors, specialists, and many audiences interested in reproductive support methods.
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Speaking about the pre-implantation genetic testing (PGT) techniques currently used in Europe, Assoc. Prof. Dr. Francesca Spinella said: "Currently, there are three common types of pre-implantation genetic tests: PGT-A, PGT-SR, and PGT-M. PGT-A is used to detect chromosomal abnormalities, allowing the selection of embryos without chromosomal abnormalities for embryo transfer. PGT-M is a tool to detect genetic mutations that could be inherited from the parents, thereby preventing the transfer of embryos with genetic disorders. PGT-SR is a method capable of detecting structural chromosomal abnormalities of 5Mb or more in embryos, thus increasing the chances of achieving a successful pregnancy by selecting normal embryos."
In addition to the three conventional PGT tests, Assoc. Prof. Dr. Francesca Spinella also discussed two new methods: Non-invasive PGT-A (NiPGT-A) and PGT for Ploidy (Ploidy). “NiPGT-A provides the opportunity to test embryos without the need for biopsy, by analyzing DNA in the culture medium. Meanwhile, PGT for Ploidy helps detect the presence of specific chromosomal abnormalities in embryos, thus avoiding the transfer of these embryos." However, she also mentioned that more research is needed to further validate the effectiveness of these two methods.

Assoc. Prof. Dr. Francesca Spinella also addressed several audience questions, including the importance of genetic counseling in IVF procedures, criteria for selecting mosaic embryos for transfer, and especially the appropriate timing for performing PGT methods, especially PGT for Ploidy. She spent a lot of time discussing the advantages, practical applications, and outcomes that can be achieved by using the genetic testing methods currently applied in Europe.
Understanding the concerns of infertile couples about the cost of these procedures, Assoc. Prof. Dr. Francesca Spinella shared: "The new PGT tests are optimal methods, incorporating advanced techniques from pre-implantation genetic screening. Therefore, it is understandable that the costs of these tests are slightly higher. However, in the future, the cost of these tests may decrease due to rapid technological advancements and the widespread adoption of testing. For example, the first PGT tests had extremely high costs when they were first introduced, but over time, the costs have stabilized, allowing many patients to access this method."
Notably, during the conversation, Assoc. Prof. Dr. Francesca Spinella provided in-depth insights and timely answers, helping doctors, specialists, and viewers better understand the application of current pre-implantation genetic tests. The Talkshow program was a success, attracting thousands of views, numerous shares, and receiving a lot of support from the audience.

Before concluding the Talkshow, Assoc. Prof. Dr. Francesca Spinella shared that she was very impressed after visiting some PGT and IVF labs in Vietnam, particularly GENTIS. She further mentioned that she was impressed with the facilities and the quality of healthcare professionals in Vietnam. Additionally, Assoc. Prof. Dr. Francesca Spinella noted that “Vietnam’s healthcare services in general, and reproductive support in particular, have a lot of potential for development” and emphasized the collaborative relationship within the Eurofins family, both scientifically and commercially.
We hope that the insights shared by the experts during the Talkshow will be beneficial for doctors and the audience. GENTIS Genetic Counseling Center sincerely thanks the doctors, partners, experts, and clients for their participation. We will continue to organize more Genetic Counseling Talkshow programs to provide valuable information to the audience.



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            [title] => Genetic Counseling and PGT Testing: From International Guidelines to Clinical Practice in Vietnam
            [description] => Currently, the demand for Preimplantation Genetic Testing (PGT) among couples at high genetic risk, who wish to have healthy children, is increasing. Preimplantation Genetic Testing (PGT) was developed to screen and detect genetic abnormalities in embryos before they are implanted into the mother’s uterus.
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With advances in technology and testing methods, PGT continues to be developed and clinically validated, thereby improving the success rates of assisted reproductive treatments. This is especially beneficial for parents with genetic diseases, allowing them to have healthy children free from genetic disorders.
According to global publications and studies, using next-generation sequencing (NGS) technology, current PGT tests can screen for and detect abnormalities in chromosome number (aneuploidy) across 23 pairs of chromosomes, known as PGT-A, structural chromosome abnormalities (addition/deletion/duplication), known as PGT-SR, single-gene disorders, known as PGT-M, and recently, some reports have emerged regarding the development of PGT for polygenic diseases (PGT-P). As the use and complexity of preimplantation genetic testing (PGT) increases, genetic counseling has become an essential part of modern medicine. GENTIS successfully organized a scientific seminar on "Genetic Counseling and PGT Testing: From International Guidelines to Clinical Practice in Vietnam."

At the seminar, Specialist Doctor Level 1 Nguyen Van Thong,, Head of the Department of Medical Genetics at Hung Vuong Hospital, explained: "Genetic counseling is a process that provides information, support, and guidance related to genetics and genetic risk factors for individuals or families. It helps assess the likelihood of inheriting genetic diseases based on family history or genetic test results. Additionally, it provides knowledge about genetic-related diseases or conditions, such as cancer, genetic disorders, or congenital abnormalities.
Furthermore, doctors will counsel on the benefits, limitations, and risks of genetic tests to help patients make informed decisions. Once the genetic test results are available, the doctor will explain the results and their implications for personal and family health. In addition, genetic counseling also provides psychological support to help patients and families deal with worries or emotions related to the results or genetic risks. Moreover, doctors will discuss follow-up, treatment, or prevention measures based on genetic risks."

Specialist Doctor Level 1 Nguyen Van Thong, also emphasized the importance of collaboration among genetic specialists, infertility doctors, embryologists, and healthcare workers to ensure the highest efficacy in the testing process. He also shared the role of PGT in supporting couples to have healthy children by screening and detecting genetic abnormalities. Technological advancements in PGT-A/SR and PGT-M not only increase the chances of successful pregnancies but also reduce the risks of miscarriage and serious genetic diseases in the fetus.
From a clinical perspective, Dr. Le Thi Minh Chau, Head of the Infertility Department at Tu Du Hospital, shared that over the past thirty years, there have been rapid advancements in genetic testing and assisted reproductive technology, reshaping the PGT testing process. The development of whole genome amplification (WGA) tools, combined with optimized hormonal stimulation protocols and more effective cryopreservation methods, has led to more accurate diagnoses and improved clinical outcomes. Furthermore, the shift from day 3 to day 5 or early day 6 embryo biopsy has altered the timeline for a typical PGT clinical process.

Although PGT helps reduce pregnancy terminations, in cases such as families with single-gene disorders, PGT is a relevant option for preimplantation genetic diagnosis. However, PGT remains a solution that requires discussion and consensus guidelines. Some of the complexities in the IVF process are especially relevant for couples without fertility issues, including the risk of diagnostic errors, potential embryo damage from invasive procedures, and ethical concerns. Therefore, the decision to undergo PGT is complex and always involves a stressful decision-making process.
Sharing her experience with PGT testing in Europe, Prof. Dr. Francesca Spinella, Senior Medical Information Specialist at Eurofins Genoma Group and Senior Consultant at GENTIS, explained: "Preimplantation Genetic Testing is a growing trend in Europe and globally. PGT analyzes genetic abnormalities (gene level and chromosomal abnormalities) in embryos before transferring them into the mother's uterus, helping to select embryos with a high implantation potential and a good chance of producing a healthy baby. However, in Europe, only reputable tests such as PGT-A, PGT-SR, and PGT-M are accepted and widely monitored by the ESHRE PGT Consortium."
The ESHRE PGT Consortium, founded in 1997, is responsible for collecting data on the accuracy, reliability, efficacy, and safety of PGT-A, PGT-M, and PGT-SR. It also establishes minimum standards and promotes best practice guidelines. Additionally, the Consortium facilitates the exchange of ideas and perspectives among members.
At the seminar, Prof. Dr. Francesca Spinella also introduced new PGT tests being developed at Eurofins Genoma Group. She noted that Eurofins Genoma Group is researching and developing a new PGT testing package called PGT Next. PGT Next, in addition to detecting chromosomal abnormalities such as PGT-A/SR, can also detect aneuploidy, identify euploid embryos without abnormalities, even in cases of embryo morphological abnormalities.
Through the seminar "Genetic Counseling and PGT Testing: From International Guidelines to Clinical Practice in Vietnam," GENTIS hopes that attendees have gained new information and knowledge about preimplantation genetic testing (PGT) and a clearer understanding of the value and applicability of PGT tests in assisted reproduction. This will contribute to improving clinical outcomes, supporting patients in making informed decisions, and increasing the chances of successful pregnancies and healthy babies.
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            [title] => Associate Professor Francesca Spinella Visits GENTIS Partner Hospitals: Strengthening Collaboration and Advancing Genetic Testing in Vietnam
            [description] => During her visit to Vietnam, Professor Francesca Spinella (Senior Medical Information Specialist at Eurofins Genoma Group and Senior Expert Advisor to GENTIS) engaged in a series of significant activities at GENTIS and with partner institutions, including Hanoi’s Infertility and Andrology Hospital, Hanoi General Hospital, and Lac Viet Friendship Hospital. These expert meetings concluded successfully, laying the foundation for deeper, future collaboration between GENTIS, Genoma, and the partner hospitals.
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Professor Francesca Spinella's Official Visit to GENTIS Partner Institutions
As part of her work trip to Vietnam, Professor Francesca Spinella, accompanied by GENTIS experts, visited several prominent institutions in the field of reproductive health, including Lac Viet Friendship Hospital, Hanoi General Hospital, and Hanoi Infertility and Andrology Hospital. These hospitals are strategic partners of GENTIS in implementing and applying advanced genetic testing techniques.
The first stop for Professor Francesca Spinella and the GENTIS team was Lac Viet Friendship Hospital. Professor Ivan Reich, Director of the Vietnam IVF Center, along with the medical and lab teams, welcomed the group and held productive discussions with Professor Spinella and the GENTIS experts.
At this hospital, Professor Spinella gave a brief presentation on “Latest Updates in Genetic Testing for Reproductive Support, Sharing Experience from Europe.” She highlighted the advanced PGT (Preimplantation Genetic Testing) techniques used at Eurofins Genoma Group, offering valuable insights to doctors and enhancing their knowledge of the latest technologies. This, in turn, helps improve the quality of diagnosis and treatment for couples seeking to have children.

At Hanoi General Hospital, Professor Spinella continued to share knowledge on modern genetic methods used globally, discussing how to implement these practices in treatment. Of particular note were the latest PGT techniques for screening genetic abnormalities before in vitro fertilization (IVF). This is crucial as demand for reproductive healthcare rises, with more couples aiming for healthy children, especially those dealing with genetic conditions. The session was well-received by the leadership and medical staff at the Hanoi IVF Center.
The final visit for the GENTIS delegation was to Hanoi Infertility and Andrology Hospital. There, Professor Spinella and the GENTIS team conducted a direct expert exchange on pre-implantation genetic testing (PGT) packages and addressed numerous questions from the medical staff. The meeting provided fresh perspectives to doctors, helping them enhance their expertise in patient counseling and treatment.
After these visits, Professor Francesca Spinella expressed her admiration and positive impressions of the professional standards, systematic investment, and the noble mission of the hospitals in Vietnam. She also extended her gratitude to the representatives of the institutions for their warm and thoughtful reception.
The Importance of Collaboration between GENTIS and Vietnamese Hospitals
Professor Spinella’s visit to Vietnam provided an excellent opportunity for GENTIS and partner hospital doctors and experts to access advanced knowledge in reproductive support, and opened the door to long-term collaboration. With the mission of "Enhancing the physical and intellectual well-being of the Vietnamese people," GENTIS is committed to supporting partner hospitals in Vietnam by boosting professional capabilities, improving treatment quality, and increasing success rates in infertility treatment. With the backing of top experts, GENTIS pledges to stand by Vietnamese hospitals and families as they pursue their dreams of parenthood.
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            [title] => Genetic test applications in enhancing the effectiveness in assisted reproductive examinations and treatments 
            [description] => Genetic tests play a crucial role in determining infertility causes and assisted reproduction treatments. In Vietnam, GENTIS has acquired many achievements in researching and developing advanced genetic tests, positively benefiting the patients as well as enhancing the effectiveness in assisted reproductive treatments. 
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Genetic roles in assisted reproduction
According to the World Health Organization’s statistics, infertility affects approximately 10% of couples of productive age. WHO has also pointed out that Vietnam is among the nations having the highest infertility rate in the world, in which 50% are those under 30. In Vietnam, It is estimated that 1 million couples face with infertility annually, accounting 7,7%
The infertility rate is equally 40% for male and female, 10% for both spouses, and 10% with unidentified causes. This phenomenon indicates that infertility can be attributed to both male and females. 

Dr. Pham Dinh Minh presented the report “Researching and applying genetic tests in enhancing the effectiveness in assisted reproduction examinations and treatments in Vietnam”

In addition to causes such as pathology, environment, and lifestyle; Genetics and abnormalities due to mutations in genes also cause infertility. Presenting at the 5th annual science conference HASAM 2024, Dr. Pham Dinh Minh (Director of R&D department at GENTIS) revealed “Genetics is involved in virtually all assisted reproductive processes, facilitating the diagnosis of genetic pathologies and their prevention in subsequent generations, determining and diagnosis of infertility’s root causes, recurrent miscarriages, and supporting reproductive enhancement. Notably, the collaboration between genetic geneticists and clinicians, along with embryologists, contributes to establishing precise diagnoses and the most suitable, effective, and optimal assisted reproduction treatment strategies for patients”. 

According to the experts, genetic screening before embryo transfer is an essential breakthrough in the assisted reproduction field. Preimplantation Genetic Testing/ PGT analyzes genetic abnormalities ( in gene and chromosome level ) in embryos before being transferred into the mother’s uterus. 

Associate Professor Francesca Spinella presented the report: “Advances in Preimplantation Genetic Screening: A European Perspective and Data from the European Society for Human Reproduction and Embryology (ESHRE) PGT Consortium.”


Sharing about advancements in preimplantation genetic screening in Europe, Senior Expert Advisor of GENTIS - Assoc Prof. Dr. Francesca Spinella (Former president of the ESHRE PGT Consortium and Senior Medical Information Specialist at Eurofins Genoma Group) noted “There are 3 traditional types of preimplantation genetic testing (PGT) commonly used: PGT-A, PGT-SR, and PGT-M. In which, PGT-A helps identify euploid and aneuploid embryos, thus increasing the chances of success in in vitro fertilization (IVF). PGT-SR can detect structural abnormalities larger than 5Mb, allowing for the selection of normal embryos, thereby improving the likelihood of achieving a successful pregnancy. PGT-M is used to screen for single-gene inherited diseases, ensuring that only embryos free from genetic mutations are selected for transfer”.
Currently, Eurofines Genoma Group is researching and developing new PGT testing packages namely niPGT-A and PGT Next. NiPGT-A is a non-invasive PGT-A test performed on the used culture medium. Notably, PGT Next can detect chromosomal abnormalities, both number and structure, like PGT-A/SR, but it also has the capability to detect polyploidy and identify diploid embryos without abnormalities, even in cases of morphological abnormalities,” added Assoc Prof. Dr. Francesca Spinella.
GENTIS's Ecosystem of Genetic Tests in Reproductive Medicine
The presentation “Research and Application of New Genetic and Genomic Tests to Improve Reproductive Health Diagnosis and Treatment in Vietnam” by Dr. Pham Dinh Minh (Director of R&D at GENTIS) drew significant attention at the HASAM 2024 Annual Scientific Conference. Dr. Minh's report highlighted how modern genetic testing technologies have benefited patients and improved the effectiveness of reproductive treatments.

Eurofins Genoma Collaborates with GENTIS to Develop Advanced Genetic Testing Technologies
The report “Researching and applying new genetic tests to enhance the effectiveness in assisted reproductive examinations and treatments” performed by Dr. Pham Dinh Minh (Director of R&D department at GENTIS) had drawn huge attention from delegates at the HASAM 2024 conference. Dr. Minh’s report pointed out that advanced genetic tests have benefited patients as well as enhanced the effectiveness in assisted reproductive treatments. 

GENTIS is proud to be a leading Genetic Testing Center in Vietnam with state-of-the-art equipment. Notably, GENTIS is also the first genetic testing facility in Vietnam to achieve international standards – ISO 15189:2022 accredited by BoA and ISO/IEC 27001:2022 accredited by GICG, while fully complying with the strict regulations of the Ministry of Health and international external quality control programs.
Currently, GENTIS offers a complete ecosystem of genetic tests for reproductive support, including tests for parents, embryos, and conditions for embryo transfer; as well as tests for maternal health and pregnancy. These specialized tests help identify the causes of infertility in both men and women, screen for genetic abnormalities, prevent rare diseases in preimplantation embryos, and support embryo transfer and pregnancy monitoring. Conducting these in-depth tests enables clinicians to provide effective treatment solutions, helping to make the dream of parenthood a reality for many families facing infertility challenges.
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            [title] => GENTIS - A golden sponsor at the 5th annual scientific conference HASAM 2024
            [description] => On December 8, 2024, the 5th annual scientific conference HASAM 2024 with the theme “Updates on advanced in science and technology to enhance the effectiveness of infertility treatment”, organized by the Hanoi Assisted Reproductive Support Association (HASAR) was successfully held at the Pullman hotel, Hanoi. GENTIS was honored to be a sponsor and have a booth showcasing solutions for improving the effectiveness of reproductive support. 
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This year’s annual scientific conference HASAM attracted over 250 delegates including experts, technicians, doctors, etc. currently working in the field of assisted reproduction in order to help them cultivate and interchange experiences in clinical practice, laboratory work, as well as update latest knowledge in treatment, research and technological activities. The symposium went successfully with 28 reports at the main hall and 20 high-quality scientific poster presentations. 

Delegates had chances to present, share and actively discuss, gaining the most recent and in-depth clinical knowledge and experiences in the field of assisted reproduction. The common goal was to enhance the effectiveness of diagnosing and treating infertility, thereby contributing to the improvement of public health care quality.

Attending the symposium this year, Dr. Pham Dinh Minh (Director of R&D department at GENTIS), honorably represented GENTIS to present the report “Research and application of new genetic tests to improve the effectiveness of infertility diagnosis and treatment in Vietnam”. In the report, Dr. Minh emphasized that genetic tests play a crucial role in detecting the causes of infertility and enhancing assisted reproductive treatments. 
The understanding of pathogenesis mechanisms and the development of science and technology has led to many superior diagnostic tests in reproductive support. GENTIS has been researching modern genetic testing technologies that benefit patients, improving the effectiveness in assisted reproduction treatments, including PGT A/SR, PGT-M +100 rare diseases, PGT-Max 1, Karyotype, Fertiscan, Thalassemia, and many more.

Additionally, Dr. Minh also took the role as the Chair of Session B from 10:00 - 12:00 AM, where he led discussions on new knowledge and shared valuable experiences regarding genetic tests beneficial for diagnosing and treating infertility. These contributions aim to bring healthy, happy children to families. 
GENTIS was honored to sponsor the presentation by Assoc. Prof. Dr. Francesca Spinella  (Senior Medical Information Specialist at Eurofins Genoma Group - President of the ESHRE PGT Federation) - Gentis’s senior expert advisor. Her report, titled “Advances in Pre-implantation screening: European perspectives and data from the European Society of Human Reproduction and Embryology (ESHRE)”, provided the Vietnamese medical community with the opportunity to access the latest advancements in pre-implantation screening. 

This year, GENTIS proudly contributed to the success of the conference as a gold sponsor. Attending the event, GENTIS’s expert team had fully observed all scientific sessions and updated the latest knowledge in the field of assisted reproduction with the spirit of continuous learning. 
Additionally, GENTIS’s booth, placed in the exhibition area, received significant attention from delegates. With the help of professional consultants, the genetic tests offered by GENTIS quickly captivated the interest of a large number of attendees. 
GENTIS would like to express our gratitude to the doctors and experts who attended and showed interest with our testing services. With the mission of “Enhancing the physical and intellectual well-being of the Vietnamese people”, GENTIS aims to bring more genetic tests and clinical applications to fertility specialists, contributing to the development of the assisted reproduction field and reproductive health care in Vietnam. Through this, we strive to advance the field of medical genetics to provide the best benefits to patients. 
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            [title] => GENTIS Updates Knowledge on Preimplantation Genetic Testing (PGT) for doctors at Viet Duc General Hospital
            [description] => On the afternoon of Friday, 8 November 2023, GENTIS collaborated with Viet Duc (Phu Tho) General Hospital to host a seminar introducing preimplantation genetic testing (PGT) in order to enhance and update professional knowledge for the doctors and medical staff at the hospital. At the seminar, GENTIS’s representatives had interchanged and answered questions coming from doctors and medical staff at Viet Duc General Hospital.
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The event was attended by Dr. Pham Thi My Hanh (Director of Viet Duc's Reproductive Health Division), MSc. BSNT Luu Xuan Ky (Head of the Viet Duc Lab), alongside other doctors and nurses from the hospital. From GENTIS, Mr. Nguyen Quang Vinh (Director of the Testing Center) and Mr. Pham Dinh Minh (Director of R&D) participated in the seminar.

Mr. Nguyen Quang Vinh had presented GENTIS’s detailed PGT packages namely PGT-A/SR, PGT-M, PGT-Max 1 and their effectiveness in optimizing the chances of a healthy pregnancy for infertile couples. A key highlight of the seminar was the discussion about the benefits of PGT testing in supporting reproductive health. According to Mr. Nguyen Quang Vinh, the test not only helps to detect genetic abnormalities but also reduces the risk of miscarriage, increases the success rate of in vitro fertilization (IVF), and assists in selecting healthy embryos for implantation. 
PGT testing can also help couples avoid difficult and heartbreaking situations, such as dealing with an unhealthy pregnancy or the birth of a child with a serious genetic disorder. This is particularly beneficial for older couples or those with a history of genetic conditions, as PGT serves as a valuable tool in reducing these risks.

During the seminar, doctors at Viet Duc General Hospital raised several questions related to GENTIS’s PGT testing and services such as : "How is the PGT-A/SR, PGT-M, PGT-Max 1 process carried out at GENTIS?" and "Is NIPT testing required after undergoing PGT?". In response, Mr. Nguyen Quang Vinh and Mr. Pham Dinh Minh provided detailed answers, focusing on the key aspects, which helped the doctors gain a better understanding of the PGT testing packages at GENTIS. 
The seminar took place in a lively atmosphere and received positive feedback from the attending doctors. Dr. Pham Thi My Hanh expressed her appreciation, stating, "We sincerely thank GENTIS for organizing such a useful seminar. The doctors from the Reproductive Medicine Department at Viet Duc General Hospital have gained new knowledge about PGT testing, especially advanced genetic screening methods and their clinical applications at GENTIS."
The seminar introducing preimplantation genetic testing (PGT) at Viet Duc General Hospital (Phu Tho) provided doctors with valuable updates in the fields of reproductive support and the diagnosis of genetic abnormalities. PGT is not only an advancement in medical science but also brings hope to many infertile families in their journey to have a healthy child.
With the development of genetic analysis technology and the clinical application of PGT, couples now have more opportunities to have healthy children, reduce genetic risks, and improve their quality of life. This event not only helped doctors enhance their professional knowledge but also contributed to the further development of the healthcare sector, particularly in reproductive medicine in Vietnam.
It is hoped that following this seminar, GENTIS and Viet Duc General Hospital (Phu Tho) will continue to expand their collaboration for the development of both institutions.



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