Specialized news

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            [slug] => Gentis-collaborates-with-the-department-of-andrology-and-sexology-hanoi-university-of-medicine-to-organize-a-scientific-seminar
            [title] => GENTIS collaborates with the Department of Andrology and Sexology - Hanoi University of Medicine to organize a scientific seminar
            [description] => Recently, GENTIS collaborated with the Department of Andrology and Sexology at Hanoi University of Medicine to successfully organize a scientific seminar aimed at helping doctors and healthcare staff gain a better understanding of two specialized test packages: Whole Exome Sequencing (WES) and Sperm DNA Fragmentation.

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The seminar at Hanoi University of Medicine was attended by numerous experts and doctors from the Department of Andrology and Sexology, such as Associate Prof. Dr. Nguyen Hoai Bac (Head of the Department), MSc. Dr. Tran Van Kien, MSc. Dr. Do Ich Dinh, MSc. Dr. Chu Thi Chi, and MSc. Dr. Nguyen Cao Thang. From GENTIS, the seminar was attended by MSc. Hoang Thi Nhung (Head of R&D) and MSc. NT. Vu Thu Huong (R&D Specialist).

At the beginning of the seminar, MSc. NT. Vu Thu Huong explained that high levels of sperm DNA fragmentation are one of the causes of male infertility. There are many factors that lead to sperm fragmentation. According to MSc. NT. Vu Thu Huong, Sperm DNA testing is an essential method for evaluating the overall quality of a patient's sperm. This test helps quantify the percentage of sperm DNA fragmentation by detecting color changes in a dye through a flow cytometry system (which analyzes up to 10,000 sperm), helping identify the cause of infertility in cases where the semen analysis result is normal.
In addition, the sperm DNA fragmentation test can also explain repeated miscarriages, unexplained infertility, and failed IVF attempts. Therefore, evaluating sperm quality through sperm DNA fragmentation testing is extremely necessary, as it helps doctors predict fertility potential and determine the most suitable intervention for assisted reproduction.
At GENTIS, sperm DNA fragmentation (Sperm DNA) tests are conducted using the SCSA (Sperm Chromatin Structure Assay) method, ensuring high stability, accuracy, and performance.
A unique feature of this test is the clear categorization of sperm DNA fragmentation thresholds. This helps doctors better screen cases of unexplained infertility, thus guiding treatment intervention.
In addition to the Sperm DNA fragmentation test, the seminar also featured a discussion of new information about the Whole Exome Sequencing (WES) test. According to MSc. Hoang Thi Nhung (GENTIS), WES is a DNA sequencing method aimed at analyzing the entire protein-coding region, or Exons, in the human genome. GENTIS uses next-generation sequencing (NGS) technology on the NovaSep 6000 system to sequence the entire exon region of around 22,000 genes (covering over 85% of disease-causing mutations). This allows for the detection of point mutations, small deletions/inserts, and CNVs. Whole Exome Sequencing provides the ability to diagnose genetic diseases of unknown causes, particularly rare and complex diseases, and detect genetic variants associated with neurological, cardiovascular, and other conditions.

Through the discussion, doctors from the Department of Andrology and Sexology at Hanoi University of Medicine highly appreciated the significant improvements in WES and Sperm DNA testing and posed many in-depth questions regarding these two tests. This demonstrates the interest of medical professionals in GENTIS’s WES and Sperm DNA tests. We hope that after this scientific seminar, GENTIS will continue to have the opportunity to collaborate and work with Hanoi University of Medicine in the future!
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            [title] => The role and connection between clinical doctors, geneticists, and genetic labs in diagnosis and screening of genetic diseases
            [description] => In modern medicine, particularly in the diagnosis and screening of genetic diseases, the collaboration between clinical doctors, geneticists, and genetic laboratories plays an extremely important role. This is a closed-loop process that ensures patients receive accurate results, supporting the best treatment and prognosis possible.
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The Importance of Genetic Testing in Diagnosis and Disease Screening 
According to Ms. Katie Battese Ellis (Senior Director of Medical Affairs at Illumina in several APAC countries), in the past, there were not many available tests, so doctors often gathered the patient's characteristics to identify any potential issues. However, with the development of modern medicine, numerous genetic tests are now available, making the diagnosis and screening of diseases easier.
Dr. Pham Dinh Minh, Ms. Katie Battese Ellis, and Associate Prof. Dr. Ho Sy Hung (from left to right) 
With these advancements, we can conduct pre-pregnancy tests to see if both partners are carrying the same genetic condition. Pregnant women can undergo testing to monitor fetal development. Newborn screening tests can also be performed to detect conditions that may affect the health and development of the child later on.
From the test results, geneticists and clinical doctors will discuss and create a plan for better monitoring or treatment for the patient. This not only helps save time and treatment costs but also ensures the health and future happiness of the entire family.
As one of the leading experts in reproductive medicine in Vietnam, Associate Prof. Dr. Ho Sy Hung (Deputy Director of the National Reproductive Support Center) mentioned that the collaboration between genetic experts and clinical doctors is crucial. In reproductive medicine, the success rate of pregnancy is about 50%. However, some patients experience repeated miscarriages for unknown reasons, have a history of genetic diseases, or have undergone multiple IVF cycles without success. These cases require pre-implantation genetic testing (PGT) to select healthy embryos for implantation.
Currently, there are three types of traditional PGT tests: PGT-A, PGT-SR, and PGT-M. PGT-A helps identify normal embryos and increases the chances of success in IVF. PGT-SR can detect unbalanced translocations in embryos before transfer, allowing for the selection of normal embryos, thus increasing the chances of a successful pregnancy. PGT-M is used to screen for monogenic genetic diseases, ensuring that only embryos without genetic mutations are transferred.
GENTIS is a pioneering unit in Vietnam capable of accurately and professionally performing PGT tests with the most advanced techniques, along with a team of highly qualified experts. Notably, GENTIS can screen for about 100 monogenic diseases using PGT-M.

In addition, GENTIS also offers PGT NEXT and PGT UPGRADE with outstanding advantages. PGT NEXT can detect chromosomal abnormalities on all 24 chromosomes, additional abnormalities, chromosomal segment deletions, and aneuploidy. Meanwhile, PGT UPGRADE can detect chromosomal abnormalities, segment deletions, and balanced translocations inherited from parents.
Experts Participating in the Genetic Counseling Talkshow – Discussion with Experts at GENTIS

At GENTIS, PGT testing is conducted in an ISO-standard lab using advanced genetic sequencing methods like NGS, Sanger, or PCR, carried out by skilled technicians and experienced analysts. Afterward, geneticists provide the final conclusions and send them to clinical doctors for patient consultation, ensuring the transfer of healthy embryos into the mother's uterus.
According to Dr. Pham Dinh Minh, genetic and genomic testing is booming in Vietnam. Therefore, GENTIS needs the collaboration between doctors, geneticists, and labs to make genetic tests more accessible and useful, especially in reproductive medicine, obstetrics, and newborn screening.
In the near future, GENTIS will incorporate AI and bioinformatics to screen for more diseases and provide more clinical information to assist doctors in offering the best treatment options for patients.
The Connection Between Clinical Doctors, Geneticists, and Genetic Labs 
The close collaboration between clinical doctors, geneticists, and genetic laboratories is crucial for the effectiveness of disease diagnosis and treatment. According to Ms. Katie, learning and sharing expertise is essential to strengthen cooperation among all parties.
Genetic labs should regularly update new tests, techniques, accuracy, and result turnaround times to ensure that clinical doctors and patients are better informed about the tests. This will help doctors develop the best treatment plan to save costs for patients.
Dr. Minh took Ms. Katie on a tour of the GENTIS testing center

From the clinical doctor's perspective, Associate Prof. Dr. Hung pointed out that genetic issues are challenging for both general clinical doctors and obstetricians in particular. Since tests and techniques in reproductive medicine are constantly developing and changing, continuous learning is necessary to share knowledge and assist patients.
For genetic labs, the quality of testing is the key. Based on test results, doctors can accurately diagnose diseases and develop appropriate treatment plans. Therefore, to bring new, high-quality tests to the market, the support of not only medical experts but also geneticists and technology innovators is essential, as Dr. Minh emphasized.
Based on modern medical advancements and technological progress, genetic testing is increasingly becoming an essential tool for screening and diagnosing diseases. However, to ensure maximum effectiveness, clinical doctors, geneticists, and genetic labs must work closely together. Only by functioning as a unified system can the healthcare system provide the most accurate, personalized, and optimal care for patients.
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            [slug] => Gentis-updated-information-about-2-screening-packages-PGT-NEXT-and-PGT-UPGRADE-at-An-Viet-General-Hospital
            [title] => GENTIS updated information about 2 screening packages: PGT NEXT and PGT UPGRADE at An Viet General Hospital
            [description] => Recently, GENTIS, in collaboration with An Viet General Hospital successfully held a scientific conference aimed at updating the information about 2 new PGT screening packages: PGT NEXT and PGT UPGRADE. At the event, a GENTIS representative provided detailed answers to the questions from doctors at the IVF An Viet Reproductive Center related these two advanced pre-implantation genetic testing packages.
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Attendants at the scientific seminar at An Viet General Hospital included PhD. Dr. Le Minh Chau (Head of the Obstetrics and Gynecology Department at An Viet Hospital), Dr. Mai Thi Giang (Head of the IVF Lab), Dr. Dang Van Ha (Reproductive Support Department), as well as nurses, healthcare staff, and laboratory technicians. From GENTIS, the event saw the presence of MSc. Nguyen Van Huynh (Head of R&D Department at GENTIS) and Ms. Duong Thi Phuong (Head of PM Department at GENTIS)
Throughout the seminar, MSc Huynh provided detailed presentations about PGT NEXT and PGT UPGRADE tests, highlighting the superior features of these two cutting-edge testing solutions.

Regarding PGT NEXT, MSc. Huynh explained that this is an advanced method in in-vitro fertilization (IVF) that analyzes and detects genetic changes in embryos before they are implanted in the uterus. The primary function of this test is to detect genetic disorders, gene mutations, and conditions that could cause health problems for the child or increase the risk of miscarriage.
By using Next-Generation Sequencing (NGS) technology, PGT-NEXT provides higher accuracy compared to traditional testing methods, enabling the selection of healthy embryos, reducing the risk of inherited diseases, and increasing the success rate of pregnancy. This tool is crucial for couples at high genetic risk, offering them a better chance of having a healthy baby. Additionally, this test can be extended to patients with a history of polyploid pregnancies, molar pregnancies, or recurrent miscarriages after undergoing traditional PGT-A IVF, increasing the number of embryos suitable for transfer from fertilized embryos with abnormalities (0PN, 1PN, or 2.1/3PN).
Discussing PGT-UPGRADE, MSc. Huynh mentioned that this is an advanced genetic screening method that detects embryos with balanced translocations. "Balanced translocation is a phenomenon where DNA segments are exchanged between non-homologous chromosomes without increasing or decreasing genetic material at the breakpoints. Balanced translocations are divided into two types: reciprocal translocation and Robertsonian translocation."
Compared to previous traditional PGT methods, PGT-UPGRADE uses NGS technology combined with targeted SNP sequencing, providing higher resolution in detecting aneuploidy, chromosomal structural abnormalities, and complex genetic changes. This method is especially useful for detecting small chromosomal abnormalities and balanced genetic translocations that older methods could not identify, thus helping select healthy embryos, reducing the risk of miscarriage or the birth of children with genetic disorders. PGT-UPGRADE not only increases the success rate of pregnancy but also offers great hope for couples with a history of genetic disorders or recurrent miscarriages, demonstrating its superiority in accuracy and effectiveness over older genetic screening methods.

The seminar took place in a lively atmosphere, receiving positive feedback and interest from the participating doctors. Questions related to PGT-NEXT and PGT-UPGRADE from the doctors of An Viet General Hospital were thoroughly answered by the GENTIS representatives. At the conclusion of the seminar, the doctors at An Viet General Hospital highly appreciated the two advanced tests offered by GENTIS, stating, "These tests are not only a breakthrough in medicine but also bring new rays of hope to couples on their journey to find their beloved child."
GENTIS hopes that after this informative exchange, it will continue to have the opportunity to accompany and collaborate with An Viet Hospital in the future!

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            [slug] => Application-of-pgt-m-tests-in-thalassemia-genetic-disorder-screening
            [title] => Application of PGT-M tests in Thalassemia genetic disorder screening
            [description] => Thalassemia is a recessive inherited anemia disorder on the autosomal chromosome, with the highest incidence rates globally, including in Vietnam. Thalassemia causes severe consequences for the material and mental well-being of affected individuals and their families. Currently, there is no definitive cure for this disease, but proactive prevention and screening are possible. Notably, the advent of Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) helps reduce the risk of having children affected by Thalassemia.
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Thalassemia – A Recessive Genetic Disorder to Be Aware Of
Thalassemia (also known as congenital hemolysis) is the most common single-gene genetic disorder worldwide. According to reports from the Thalassemia Federation and WHO in 2008, approximately 7% of the global population carries the disease gene. For every 100 couples, about 1.1 couples are at risk of having a child with the disease or carrying the Thalassemia gene.
Dr. Le Thao Ly (Quang Ninh Obstetrics and Pediatrics Hospital) reported at the 2025 Clinical Embryology Conference.
In Vietnam, Thalassemia is the leading cause of severe anemia and hemolysis in children. According to the Vietnam Congenital Hemolysis Association, there are about 12 million carriers of the disease gene, and an estimated 20,000 patients need treatment each year.
Couples who carry the Thalassemia gene have a 50% chance of having a child who carries the gene and a 25% chance of having a child with the disease if they conceive naturally. Therefore, couples planning for pregnancy, especially those with a family history of Thalassemia, should take preventive measures for the future generation by undergoing screening for early detection and appropriate preventive actions using PGT-M.
PGT-M Testing Helps Thalassemia-Carrying Parents Have Healthy Children
According to Dr. Le Thao Ly (Quang Ninh Obstetrics and Pediatrics Hospital), who presented at the 6th CEC Conference, PGT-M (Preimplantation Genetic Testing for Monogenic Gene Disorders) was first reported in 1990 and was originally used to diagnose genetic disorders linked to the X chromosome. With this technique, we can examine the genetic makeup of embryos at a very early stage, identifying specific abnormal gene segments inherited from the parents.
As a result, embryos with the disease-causing gene are eliminated before being transferred to the mother's uterus. The effectiveness of this method has been proven to help reduce the incidence of children born with the disease and minimize the need for pregnancy termination.
PGT-M plays a crucial role in reproductive medicine but still presents some challenges.
PGT-M is a test that identifies single-gene abnormalities and mutations related to genetic syndromes such as Thalassemia, Spinal Muscular Atrophy (SMA), Hemophilia, Rett Syndrome, Polycystic Kidney Disease, and others. It is recommended for couples carrying disease-causing gene mutations who are at high risk of having a child with a monogenic genetic disorder.
PGT-M is a highly accurate technique, requiring advanced technology such as SNP (Single Nucleotide Polymorphism) analysis, STR (Short Tandem Repeat) analysis, qPCR (real-time PCR), MLPA (Multiplex Ligation-dependent Probe Amplification), or NGS (Next-Generation Sequencing), depending on the specific monogenic disorder to be analyzed. The goal is to detect gene mutations that the parents carry and can pass on to their child.
To perform PGT-M, couples typically need reproductive assistance through in vitro fertilization (IVF). Embryos created through IVF are cultured until day 5. Embryos at this stage (blastocysts) are biopsied, and 5-7 cells are extracted from the part of the embryo that will develop into the placenta. These cell samples undergo special tests to identify the disease-causing genes.
This test enables doctors to check the genetic makeup of the embryos at an early stage, allowing for the identification and removal of embryos carrying the parents' genetic disease. Only healthy embryos are transferred to the mother's uterus, increasing the chances of pregnancy and resulting in healthy children who do not carry genetic mutations for future generations.
To date, in addition to screening for Thalassemia PGT-M, GENTIS has also developed PGT-M techniques for over 100 rare genetic disorders, including Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, Hemophilia, Congenital Adrenal Hyperplasia, and more.
PGT-M Testing at GENTIS is Performed Using a Rigorous, Professional Process
Along with the application of new technologies and advanced machinery systems (Veriseq PGS technology, Illumina NGS DNA sequencing system from the USA, and SNP, STR analysis methods), PGT-M testing at GENTIS is carried out in a strict, professional manner to ensure highly reliable results. Combining PGT-M screening for monogenic genetic disorders with PGT-A/SR testing before PGT-M helps provide a comprehensive assessment of embryo quality, improving the success rate of assisted reproductive methods.
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            [title] => GENTIS introduces 2 new PGT test packages at Hospital of Post and Telecommunications
            [description] => On the afternoon of March 6, GENTIS coordinated with the Post Office Hospital to organize a seminar introducing two newly launched PGT testing packages: PGT NEXT and PGT UPGRADE. Throughout the seminar, GENTIS representatives discussed and answered questions from doctors at the Post Office Hospital about these new genetic testing packages.
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Attending the seminar, on behalf of the IVF Center, the Post Office Hospital had the presence of Master. Doctor Bach Huy Anh (Deputy Director), Master. Doctor Chu Thi Huong, Doctor CKI. Kieu Duc Ty and doctors of the department. Representing GENTIS, there was the participation of Mr. Nguyen Quang Vinh (Director of Testing Center) and Mr. Nguyen Van Huynh (Leader of R&D).
Mr. Vinh and Mr. Huynh gave a detailed introduction to the two test packages PGT NEXT and PGT UPGRADE of GENTIS. Sharing with the doctors of the HTSS Center - Post Office Hospital, Mr. Huynh emphasized the technological breakthrough of both new PGT tests.

Accordingly, the PGT NEXT test is a test that can detect haploid/polyploid embryos. According to statistics during the research process at GENTIS: "Haploid/polyploid abnormalities occur in 1-3% of all pregnancies and triploidy accounts for 15-18% of miscarriages." Therefore, detecting haploid/polyploid embryos is highly significant in increasing the success rate of IVF.
In addition, PGT NEXT also supports and complements PGT-A/SR, helping to detect polyploid embryos and identify embryos with normal diploid chromosome sets, even in abnormally fertilized embryos (e.g., 0PN, 1PN, or 2.1/3PN).
This test can be extended to patients with a history of polyploidy, molar pregnancy, and miscarriage after IVF combined with traditional PGT-A, increasing the number of embryos that can be transferred from abnormally fertilized zygotes (0PN, 1PN, or 2.1/3PN). The implementation process combines whole genome sequencing NGS (Low-pass sequencing) with targeted SNP sequencing to detect polyploidy.

For PGT UPGRADE, this is a test to detect embryos carrying balanced translocations. "Balanced translocation is the phenomenon of exchanging DNA segments between non-homologous chromosomes without increasing or decreasing genetic material at the breakpoints. In balanced translocation, there are also two types: Reciprocal translocation and Robertsonian translocation."
The PGT UPGRADE test is indicated for couples with a history of recurrent miscarriage, a family history of chromosomal abnormalities, or spouses carrying balanced translocations who do not want to pass them on to the next generation. The implementation process combines whole genome sequencing NGS (Low-pass sequencing) with targeted SNP sequencing to detect embryos carrying balanced translocations.
The outstanding advantage of the PGT NEXT and PGT UPGRADE tests is the use of specialized bioinformatics software optimized specifically for the Vietnamese population. Therefore, these two tests not only help detect genetic abnormalities but also help reduce the risk of miscarriage, increase the success rate of in vitro fertilization (IVF) and help select healthy embryos to be placed in the uterus.

At the end of the presentation, doctors at the Post Office Hospital asked many questions about PGT NEXT and PGT UPGRADE, specifically: "Is 18% of the total number of embryos the proportion of euploid embryos carrying balanced translocations?", "With this new technology, is the cost of performing PGT UPGRADE much higher than the cost of performing PGT-A?". Thanks to the detailed answers of the GENTIS representative, the doctors had a clearer view and could visualize the future development of the PGT NEXT and PGT UPGRADE tests.

The seminar took place in a very exciting atmosphere and received a lot of attention and positive feedback from the participating doctors. Master, Doctor Bach Huy Anh shared: "Thank you GENTIS for coming to our hospital today and updating new products that are extremely meaningful and highly practical. For me personally, the PGT UPGRADE test has a high humanitarian significance, helping couples with balanced translocation genes prevent the possibility of passing it on to future generations. I believe that in the future, these two tests will greatly support infertile couples with multiple miscarriages, helping them reach their dream of becoming parents."
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            [title] => GENTIS introduces FISH test and 2 new PGT test packages at Phu Tho Obstetrics and Pediatrics Hospital
            [description] => On the afternoon of March 12, GENTIS coordinated with Phu Tho Obstetrics and Pediatrics Hospital to organize a seminar introducing the FISH test and two newly launched PGT test packages: PGT NEXT and PGT UPGRADE. At the seminar, GENTIS representatives discussed and answered questions from doctors at Phu Tho Obstetrics and Pediatrics Hospital about these new genetic test packages.
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Attending the seminar, on behalf of the Center for Reproductive Support, Phu Tho Obstetrics and Pediatrics Hospital, there was the presence of Dr. Doan Trung Kien (Director), Dr. Nguyen Thi Mai (Deputy Director), Dr. Le Ngoc Tue Nhi (Head of IVF Lab) and doctors of the department. Representing GENTIS, there were Mr. Nguyen Van Huynh (Head of R&D Group) and Dr. Vu Thu Huong.
At the seminar, Dr. Vu Thu Huong gave a detailed presentation on FISH, the process, principles and values ​​that this test brings. In addition, Mr. Nguyen Van Huynh also introduced and presented in detail about the two PGT NEXT and PGT UPGRADE test packages of GENTIS. One of the highlights of the seminar was the discussion about the benefits and technology applied to the two newly launched PGT products of GENTIS. According to Mr. Nguyen Van Huynh, thanks to the use of specialized bioinformatics software optimized for the Vietnamese population, this test not only helps detect genetic abnormalities but also helps reduce the risk of miscarriage, increase the success rate of in vitro fertilization (IVF) and help select healthy embryos to place in the uterus.
PGT testing helps couples avoid difficult situations, such as facing an unhealthy pregnancy or the risk of giving birth to a child with a serious genetic disease. Especially for older couples or couples with a history of genetic disease, PGT is an effective solution, helping to screen and select healthy embryos, thereby increasing the chance of having a safe and healthy child.
During the seminar, doctors at Phu Tho Obstetrics and Pediatrics Hospital asked many questions about FISH testing as well as PGT NEXT and PGT UPGRADE: "Can embryonic cells after FISH be used for other tests?", "The time to return results of PGT NEXT seems a bit long, can it be reduced in the future?". Accordingly, Mr. Nguyen Van Huynh and Dr. Vu Thu Huong gave extremely detailed answers, delving into the issues that doctors were still wondering about. This provided doctors with a clearer understanding of the future development of FISH, PGT NEXT and PGT UPGRADE tests at GENTIS.
The seminar took place in an engaging and dynamic atmosphere and received a lot of attention and positive feedback from the participating doctors. Dr. Doan Xuan Kien said: "I am very grateful and appreciate the presence of GENTIS today, thank you for organizing such a meaningful and practical seminar, helping doctors to update new knowledge about FISH testing, as well as better understand the breakthrough and necessity of applying PGT NEXT, PGT UPGRADE in pre-embryo genetic testing technology. These tests are not only a great step forward in medicine but also bring a new ray of hope to couples on the journey to find their beloved children".
Hopefully after the seminar, GENTIS and Phu Tho Maternity and Pediatrics Hospital will have more opportunities to cooperate for the development of both units!
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            [title] => Dr. Pham Dinh Minh reported at the 7th Tzu Chi - Academia Sinica Biomedical Conference
            [description] => On March 8, 2025, Dr. Pham Dinh Minh (Director of R&D GENTIS - Director of GENTIS Genetic Counseling Center) gave a report at the 7th Tzu Chi - Academia Sinica Biomedical Conference at Tzu Chi University, Hualien, Taiwan. The report was on the topic: "Development and application of AI/Bioinformatics in genetic and genomic testing in Vietnam".
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The 7th Tzu Chi - Academia Sinica Biomedical Conference
The 7th Tzu Chi - Academia Sinica Biomedical Conference 2025 was held at Tzu Chi University, Hualien City, Taiwan. This year's conference focused on the theme of “Applications of AI in Biomedical Research” and “Multidisciplinary Perspectives in Biomedical Research & Therapy”.
Dr. Pham Dinh Minh - Director of R&D GENTIS (standing in the middle) with experts at Tzu Chi University
The conference brings together leading scientists and experts in the field of biomedical science in the world from the US, Japan, Korea, Vietnam, Thailand, Indonesia, Philippines, etc. The conference provides delegates as well as the community developing artificial intelligence in medicine in general, biomedicine in particular, with the latest research and development as well as the market in the field of research and application of AI.
Report by Dr. Pham Dinh Minh at the 7th Tzu Chi - Academia Sinica Biomedical Conference
The application of genetic and genomic testing is booming in the healthcare sector in Vietnam. Recently, we have witnessed the rapid application of tests in many healthcare areas, such as reproductive health, obstetrics and gynecology, newborn screening, cancer and cardiovascular diseases…
As we know, the development of AI has attracted many people, especially those working in the field of research and development. For the general community, the development of AI tools such as China's Deepseek or xAI's Grok has greatly changed the development as well as the application in social life.

Dr. Minh presented the report "Development and application of AI/Bioinformatics in genetic and genomic testing in Vietnam"
In the medical field, although still very new, AI has also been developed. In Vietnam, there are very good potentials, especially the amount of data, the huge amount of data related to health and testing. In particular, GENTIS is one of the large testing units and has a huge amount of data in Vietnam about genetic testing, gene testing. This is one of the advantages of GENTIS to be able to apply to develop as well as research AI in the testing field.
At the 7th Tzu Chi - Academia Sinica Biomedical Conference, the report on the topic "Development and application of AI/Bioinformatics in genetic and gene testing in Vietnam" by Dr. Pham Dinh Minh (Director of R&D GENTIS - Director of GENTIS Genetic Counseling Center) attracted the attention of many attending experts. In the report, Dr. Pham Dinh Minh shared research and applications of AI and bioinformatics in genetic and gene testing, aiming to develop new tests and improve the quality of testing. Especially genetic testing in pre-implantation embryo screening, genetic testing in non-invasive prenatal screening as well as other genetic and gene testing.

Dr. Minh received a certificate at the 7th Tzu Chi - Academia Sinica Biomedical Conference
In addition, the report also provides the conference, as well as the Asia-Pacific scientific community, with information on the development, research, and application of AI, as well as bioinformatics in Vietnam in general and the medical, genetic and genetic testing fields in Vietnam in particular.
GENTIS applies AI/bioinformatics software in genetic research and testing
“Developing AI applications/bioinformatics software is one of the key, main areas that GENTIS is oriented to develop in the coming time. GENTIS is looking forward to finding opportunities to cooperate with partners as well as developing further, researching and developing the latest directions of artificial intelligence applications as well as applying AI technology in genetic testing, genetic testing to bring new and improved tests, improving the quality of current tests”, Dr. Pham Dinh Minh shared more.
Currently, GENTIS has research projects and applications of artificial intelligence as well as bioinformatics in the field of genetic and genetic testing. Specifically, GENTIS is researching and developing AI tools, bioinformatics tools for embryo screening, improving the quality of pre-implantation genetic testing for embryos, and non-invasive prenatal screening NIPT.
Technological autonomy will help improve testing efficiency, optimize testing, improve testing quality, and use Vietnamese data. At the same time, it can help reduce testing costs, as well as bring different testing packages and testing features into GENTIS's current testing packages and testing services.
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            [slug] => https://gentis.com.vn/tin-tuc-c4/me-bau-nao-nen-thuc-hien-xet-nghiem-sang-loc-truoc-sinh-nipt-d1281
            [title] => Which pregnant women should do Non-invasive prenatal testing?
            [description] => NIPT (Non-invasive prenatal testing) is a method of prenatal screening for pregnant women before giving birth. This prenatal screening method is often chosen because of its non-invasive advantages, helping to detect many congenital malformations in the fetus early, thereby helping pregnant women to manage their pregnancy effectively.
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Who is NIPT suitable for?
With the common mentality of pregnant women being worried about the development and wanting the best care for the fetus, pregnant women always want to look for prenatal testing methods to check the health of the fetus. NIPT testing is recommended for pregnant women in the first 3 months and the middle 3 months of pregnancy, especially for those at high risk:

Pregnant women over 35 years old
According to research by experts, the quality of eggs in women after 35 years old decreases, directly affecting the embryo. Therefore, the fetus is at high risk of chromosomal disorders and is at risk of Down's, Edward's, Patau's syndrome...
In addition, women over 35 years old are often prone to problems such as uterine fibroids, endometriosis... when pregnant, their health declines, hormonal changes make the disease worse, leading to an increased risk of fetal malformations.

Family history of genetic diseases
Studies show that fetal malformations can be passed down from parents to children. If the family has parents-in-law, parents-in-law, or siblings with genetic diseases, the fetus is at high risk of malformations. Although there is no exact research on the percentage, pregnant mothers should also be screened before birth, especially by performing NIPT testing to be able to take good care of the fetus.
Pregnant women who undergo assisted reproductive techniques
The risk of birth defects in children born through artificial insemination is much higher than in children born naturally, even when maternal factors are controlled. Therefore, mothers who undergo this method are advised by doctors to use the NIPT test method.
Biochemical and ultrasound results - high-risk nuchal translucency measurement
History of pregnancy with malformations, unexplained stillbirths or giving birth to children with congenital malformations
Steps to perform NIPT testing

Step 1: Get advice from a doctor
Before taking a sample, the pregnant woman will be informed about the basic information of the NIPT test. Depending on the condition and finances of the pregnant woman, the doctor will advise on appropriate packages. Accompanying pregnant mothers on the path to reproductive health care, GENTIS provides a variety of NIPT prenatal screening service packages

 Genbasic

- Detects aneuploidy on 3 common chromosomes: Down, Patau, Edward
- Applicable for single and twin pregnancies
- Time to return results: 4 - 5 days

 Genbasic Plus

- Detects 5 syndromes: Edwards, Patau, Down, Turner (XO), Klinefelter (XXY)
- Applicable for single and twin pregnancies
- Time to return results: 4 - 5 days

 GenEva

- Detects 8 syndromes: Edwards, Patau, Down, Turner (XO), Klinefelter (XXY), trisomy (XXX), Jacobs (XYY) and detects quantitative abnormalities on all remaining chromosomes
- Applicable for single and twin pregnancies
- Time to return results: 4 - 5 days

 GenEva Plus

- Detects all all types of abnormalities in the GenEva package. At the same time, the package also detects 86 microdeletion mutations
- Applicable for single and twin pregnancies
- Time to return results: 4 - 5 days
Step 2: Take blood for NIPT screening test
Take 7-10ml of blood from the pregnant woman's arm vein for testing.
Step 3: Transfer the blood sample to the GENTIS testing center for analysis.
Step 4: Receive results after 4 - 5 days from the date of sample collection.
Step 5: After receiving the results, the doctor will analyze and advise on appropriate fetal care methods, especially in cases of genetic diseases.
Advantages of performing NIPT testing at GENTIS

High accuracy
NIPT testing is considered more accurate than traditional screening. NIPT prenatal screening is based on DNA genetic material, so it is not affected by environmental factors. In addition, the method is also performed by analyzing the new generation gene sequencing algorithm with a high-tech equipment system with an accuracy rate of over 99%.
Fast results
The test result return time is about 4 - 5 days after sample collection. The sample analysis time by machine is fast, helping NIPT test return results in the shortest time.
Safe
The test sample is the mother's blood, so the prenatal screening method does not cause any negative effects on both mother and baby. Because the test only takes 7-10ml of the mother's blood to separate extracellular DNA, then sequence the DNA and analyze.
Applicable in many cases
NIPT testing is applicable to cases of pregnant mothers with single, twin, and multiple pregnancies.
Screening and detecting diseases related to abnormal chromosomes is extremely good.
NIPT GENTIS test accompanies parents on the journey to welcome their beloved children. Contact hotline: 1800 2010 to schedule a consultation and NIPT test at GENTIS.
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