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[slug] => high-risk-individuals-and-the-etiological-factors-of-preeclampsia
[title] => High-risk individuals and the Etiological Factors of Preeclampsia
[description] => Preeclampsia is a dangerous medical syndrome that appears after the 20th week of pregnancy. For pregnant women, preeclampsia can cause hypertensive complications, kidney failure, liver damage, coagulation disorders, and life-threatening eclampsia.
[content] => What is Preeclampsia?
Preeclampsia is a multi-organ syndrome that develops in the latter half of pregnancy, classically defined by the presence of hypertension accompanied by proteinuria or multi-organ dysfunction.
- Hypertension in pregnancy is defined as the elevation of blood pressure after 20 weeks of gestation, measured on at least two occasions spaced at least 4 hours apart. In cases of pre-existing chronic hypertension where the following additional factors emerge, the condition is classified as superimposed preeclampsia on chronic hypertension.
- The key signs and symptoms used to diagnose preeclampsia include:
- Proteinuria: ≥300 mg protein on 24-hour urine collection, or Protein/creatinine ratio ≥30 mg/mmol
- Renal impairment: Serum creatinine ≥90 μmol/L
- Hepatic dysfunction: Liver enzyme levels elevated 2x above the normal range, or having abnormal upper quadrant pains
- Neurological complications: Eclampsia, stroke, altered mental status, severe headaches, visual disturbances, temporary blindness
- Hematological complications: Thrombocytopenia (<150,000/dL), Disseminated intravascular coagulation, or Hemorrhage
Who is having a high risk of preeclampsia?
According to the recommendations of the American College of Obstetricians and Gynecologists (ACOG), the following groups are identified as high-risk populations and should receive preventive treatment:
- Primigravida
- Multifetal pregnancy (twins, triplets, etc.)
- Having a history of preeclampsia in the previous pregnancy
- Systemic lupus erythematosus (SLE)
- Hemophilia
- Chronic hypertension - Hemophilia
- Pre-pregnancy body mass index (BMI) over 35 kg/m2
- Antiphospholipid syndrome
- Diabetes mellitus or gestational diabetes
- Maternal age over 35 years
- Renal disorders
- Obstructive sleep apnea
- Using assisted reproductive technologies
However, if we only follow the recommendations of ACOG, doing so could result in failing to identify and treat up to 50% of the individuals who require medical intervention.
The biological mechanism of Preeclampsia
When the embryo implants into the uterus and creates the fetus and the placenta, the trophoblast cells of the placenta then invade the spiral arteries of the mother’s uterus, and new blood vessels form to ensure a sufficient blood supply to the placenta.
In the case of women with preeclampsia, the development of these vascular structures appears to be inadequate. The placenta releases various substances into the maternal spiral arteries, including two distinct factors:
- PIGF: A pro-angiogenic factor that promotes vascular growth, facilitating improved placental development and enhanced nutrient delivery from the mother to the fetus.
- sFlt1: An anti-angiogenic factor that helps to prevent the vascular system from becoming excessive and overtaking the maternal organism, ensuring fetal development does not compromise the mother's well-being.
The ratio between the sFlt1 and PIGF factors fluctuates throughout the course of gestation. When this ratio is balanced, it helps the fetus develop without adversely impacting maternal health (this balance is not a 1:1 ratio, but rather varies across different populations and ethnicities).
When the placenta experiences inadequate perfusion, the trophoblast cells fail to adequately invade the maternal spiral arteries for some reason, leading to an imbalance between the two key factors, sFlt1 and PIGF, which in turn results in the development of preeclampsia, with the maternal blood pressure become elevated.
An sFlt1/PlGF ratio > 38 is associated with an adverse pregnancy prognosis, irrespective of whether the patient develops clinical preeclampsia. Pregnant women presenting with an elevated sFlt1/PIGF ratio above this threshold have a 2.9-fold increased risk of preterm delivery.
The preterm birth rate is up to 71% higher in pregnant women with an sFlt-1/PlGF ratio exceeding 38, compared to those with a ratio below 38. For those with an elevated sFlt1/PIGF ratio above 38, the median time to delivery is approximately 17 days (causing preterm birth or the development of complications from preeclampsia that require abortion). In contrast, those with an sFlt1/PIGF ratio below 38 have a median time to delivery of 51 days.
Preeclampsia Testing at GENTIS
First Trimester: PlGF index (gestational weeks 11-14) combined with maternal history, clinical examination findings, and ultrasound results.
Second and Third Trimesters: sFLT-1/PIGF ratio to predict adverse pregnancy outcomes in pregnant women.
- Second Trimester: 19 weeks 1 day to 24 weeks 6 days
- Third Trimester: 30 weeks to 37 weeks 6 days
- Sample required: 2 ml peripheral blood
- Turnaround time: 2 days
Preeclampsia is a severe obstetric event that requires close monitoring, as it can lead to numerous hazardous complications for both the mother and the baby. The prevention of complications can occur early if you adhere to comprehensive prenatal care and follow the pregnancy monitoring advice provided by the physician.
The ASRM 2023 Scientific Congress & Expo was held from October 14-18 in New Orleans, Louisiana
ASRM 2023 is the world’s leading and prestigious annual scientific congress organized by the American Society for Reproductive Medicine (ASRM). The 79th annual ASRM Congress attracted approximately 9,000 attendees, including experts from around the globe.
This year's theme for the ASRM Scientific Congress & Expo was “THE PAST, THE PRESENT, THE PIPELINE.” Dr. Ruben Alvero, Professor of Obstetrics and Gynecology at Stanford University and Chair of the Scientific Program, along with Dr. Samantha Butts, Chair of the Postgraduate Program, and their team, designed a comprehensive and engaging program for the conference delegates.
The richness of the program was crafted to address the need for updated knowledge and practical training for doctors, nurses, laboratory staff, embryologists, genetic specialists, and others working in the healthcare field.
At ASRM 2023, multidisciplinary experts explored the latest developments in reproductive endocrinology, infertility, basic science, genetics, male reproduction, access to care, mental health, and more. The conference content was highly appreciated by the delegates.
Representing GENTIS, the delegation was led by Mr. Do Manh Ha – CEO, Mr. Nguyen Quang Vinh – Director of the Testing Center, and Mr. Pham Dinh Minh – Director of R&D.
Mr. Do Manh Ha (CEO of GENTIS), Dr. Michael Thomas – Professor and Chair of Department of Obstetrics & Gynecology at the University of Cincinnati, and Mr. Pham Dinh Minh (Director of R&D, GENTIS) (from left to right)
Notably, the GENTIS representatives had the honor of meeting, networking, and exchanging ideas with Dr. Michael Thomas – Professor and Chair of the Department of Obstetrics & Gynecology at the University of Cincinnati. Dr. Thomas is currently the President of ASRM for 2022-2023. The meeting was highly informative, and the President graciously accepted an invitation to visit GENTIS in Vietnam in the future.
Dr. Michael Thomas – Professor and Chair of Department of Obstetrics & Gynecology at the University of Cincinnati, and Mr. Pham Dinh Minh (Director of R&D, GENTIS)
Once again, GENTIS extends its best wishes for the continued success of the ASRM 2023 Scientific Congress & Expo!
[content_more] => [meta_title] => GENTIS Participated in the ASRM 2023 Scientific Congress & Expo [meta_description] => From October 14 to 18, 2023, the ASRM 2023 Scientific Congress & Expo officially took place in New Orleans, Louisiana. GENTIS was represented at ASRM 2023 by Mr. Do Manh Ha – CEO, Mr. Pham Dinh Minh – Director of R&D, and Mr. Nguyen Quang Vinh – Director [meta_keyword] => ASRM 2023 Scientific Congress & Expo [thumbnail_alt] => [post_id] => 1148 [category_id] => 4 ) [2] => stdClass Object ( [id] => 1147 [id_crawler] => [category_product] => NULL [thumbnail] => 1-pgt.jpg [album] => [url_video] => [is_status] => 1 [is_featured] => 0 [is_form] => 0 [displayed_time] => 2023-10-17 [program] => 0 [number] => 1 [viewed] => 0 [type] => [type_career] => [level] => [address] => [address_career] => [expiration_time] => 0000-00-00 [created_time] => 2023-10-17 08:37:18 [updated_time] => 2024-08-19 14:16:14 [files] => [salary] => [time] => [created_by] => 63 [is_table_content] => 0 [language_code] => en [slug] => preimplantation-genetic-testing-for-monogenic-disorders-pgt-m-and-what-you-need- to-know [title] => Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) and What You Need to Know [description] => In the field of reproductive assistance, selecting an IVF embryo for implantation into the uterus should not solely rely on morphology but also on genetic information obtained through testing. This ensures the selection of high-quality preimplantation embryos and increases the chances of a successful pregnancy. PGT-M is performed on embryos to detect genetic disorders caused by pre-identified gene mutations or clear family history. [content] =>1. What is PGT-M?
PGT-M is a preimplantation genetic screening test for 10 common recessive single-gene disorders. This test helps couples select embryos that do not carry the disease-causing gene mutation, thereby preventing the transmission of genetic disorders to the next generation.
Candidates indicated for PGT-M typically include couples where both partners carry mutations for diseases such as Thalassemia, spinal muscular atrophy, cystic fibrosis, etc. It is also indicated for women carrying X-linked gene mutations (e.g., Hemophilia, Duchenne/Becker muscular dystrophy). Following testing, embryos free of disease-causing genes are selected for transfer into the mother's uterus.
2. Effectiveness of Preimplantation Genetic Testing (PGT-M)
PGT testing has significantly contributed to selecting the healthiest embryos for implantation, increasing the chances of conceptions, reducing miscarriage rates, improving embryo survival rates, decreasing the number of IVF cycles needed to achieve pregnancy, lowering the risk of multiple pregnancies, reducing the incidence of single-gene disorders in offspring, and saving both time and costs associated with IVF.
Moreover, PGT-M testing also identifies abnormalities and single-gene mutations associated with several genetic syndromes such as Thalassemia (including alpha and beta thalassemia), spinal muscular atrophy (SMA), Hemophilia, Rett syndrome, polycystic kidney disease, Duchenne muscular dystrophy, congenital muscular dystrophy, and more. The effectiveness of PGT-M has been clearly demonstrated in reducing the incidence of children born with single-gene disorders and minimizing the need for mid-pregnancy terminations due to abnormal fetuses.
Preimplantation genetic screening and diagnosis for severe genetic disorders are not just personal family matters but are long-term steps involving the contribution of society and the healthcare field. It helps reduce the number of children born with congenital anomalies, serious genetic disorders, and other undesirable abnormalities in couples.
3. How is PGT-M performed at GENTIS?
Currently, PGT-M testing can be performed at hospitals or specialized centers in Vietnam. GENTIS is recognized as a unit capable of performing this technique with precision and professionalism.
At GENTIS, PGT-M testing is conducted using advanced technological techniques, employing modern equipment (such as the Illumina NGS – USA, Veriseq PGS technology) and specialized analysis software (SNP, STR analysis methods). PGT-M is carefully developed and executed to provide highly reliable results.
Combining PGT-M testing for single-gene disorder screening with PGT-A for chromosomal abnormality screening allows couples to select embryos free of genetic abnormalities for transfer into the mother's uterus. With ongoing advancements in technology, GENTIS aims to successfully research and test for other rare genetic disorders, enhancing the success of preimplantation screening and helping infertile couples give birth to healthy babies.
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The conference was attended by representatives at all levels of leadership and more than 90 delegates from enterprises within the district.
Through the first nine months of 2023 report, the district leader acknowledged the contributions of businesses and production establishments to the socio-economic development of the district.
At the ceremony, Mr. Do Van Lap, Financial Director of GENTIS, delivered a speech about the company’s business activities and contributions over the past year.
Mr. Do Van Lap, Financial Director of GENTIS gave a speech at the Conference
"As a law-abiding enterprise, GENTIS consistently adheres to legal regulations and fully recognizes the importance of occupational safety and hygiene in the context of international economic integration.
Therefore, GENTIS places great emphasis on management as well as compliance with regulations regarding public order, environmental hygiene, disease prevention, tax policies, laws, ensuring job creation, income security, and social welfare for employees, thereby contributing to the socio-economic development of Tay Ho District in particular and the country as a whole.
GENTIS is also delighted to have received support and assistance from the Tay Ho District Party Committee, and we hope that there will be more opportunities for businesses to connect and collaborate , which will be created by the district's leader." Mr. Lap shared at the Honoring Conference.
Mr. Do Van Lap's speech received enthusiastic applause from all the delegates and businesses attending the conference. Following GENTIS, other enterprises in the district also delivered lively speeches and presentations to the District Party Committee.
Also at the conference, GENTIS was proud to be one of the 40 businesses in the district recognized and awarded a Certificate of Merit by the Chairman of the People's Committee of Tay Ho District.
Mr. Do Van Lap, representing GENTIS, received the Certificate of Merit from the leaders of Tay Ho District.
GENTIS would like to express our gratitude to the city’s Departments, as well as the District Party Committee, for the ongoing support of the company's activities. Once again, congratulations on the successful conclusion of the 2023 Conference to Honor Businesses and Production and Business Establishments in Tay Ho District.
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Before DNA testing, the discovery of the ABO blood type system by Austrian scientist Landsteiner in 1900 not only helped to treat patients and study about blood and blood types, but also helped investigators to trace crimes through blood traces, determine blood relations. However, the application of analyzing blood type systems only helps to exclude traces or people who are not related by blood, but it is not possible to confirm who the traces of blood belong to or whether they are related by blood.
However, it took 85 years later, in 1985, to determine the blood relationship. At that time, Alec Jeffreys and colleagues at the University of Leicester (UK) discovered the polymorphism of repeats in the human DNA molecule (Variable Number of Tandem Repeat - VNTR). Interestingly, it is worth noting that these loops in different individuals are not the same and they span across the DNA molecule.
Alec Jeffreys considers this a unique feature to distinguish one from the other. At the same time, these traits are also inherited according to Mendel's law, which is the scientific basis for determining blood relations. Thus, Alec Jeffreys' discovery is considered the first milestone that lays the foundation for DNA testing.
When did DNA testing first appear?
Next, also in 1985, Kary Mullis (1944 – 2019) invented the DNA molecular polyploidy reaction (Polymerase Chain Reation – PCR). With this reaction, from an initial very small amount of DNA, after 28-32 cycles, the amount of DNA increases to hundreds of millions of copies.
Therefore, it is very favorable for further studies, especially criminal samples that are often small and denatured. The invention of DNA polyploidy reaction is considered a breakthrough in science, especially in molecular biomedical research of the twentieth century. Therefore, Kary Mullis was awarded the Nobel Prize in 1993.
Since 1986, the British Royal Police began to apply DNA analysis techniques to identify the criminals.
A world-renowned case that first applied DNA technology was carried out in the UK in 1986. Two schoolgirls, Lynda Mann and Dawn Ashworth, both aged 15, were raped and murdered at different times, in 1983 and 1986 in the Leicestershire area. The circumstances and nature of the case were almost the same, so investigators believed that it might be the same perpetrator.
During the investigation, a local man named Richard Buckland, 17 years old, confessed to raping and killing Dawn Ashworth. The local police immediately collected a sample of this person for DNA testing, but the results did not match the sperm samples collected from the two victims.
Police had to collect more than 5,000 blood samples from male suspects aged between 17 and 34 in areas around the crime scene for DNA testing, but there was no match. The case seemed to be at an impasse.
After nearly a year at a bar, a woman overheard a man named Colin Pitchfork talking about how he tricked a friend into taking a blood sample in lieu of his own. Police immediately took a sample of his blood and examined his DNA. The results showed that his genotype exactly matched the traces in the two rapes. He was later charged and sentenced to life in prison.
In 1988, the US Federal Bureau of Investigation (FBI) also began applying DNA analysis techniques to identify criminals.
In October 1990, in the United States, the Human Genome Project (HGP) was officially launched. On February 12, 2001, HGP and Celera published the complete sequence of the human genome, a major event in the development of molecular biology in general and in the study of the human genome in particular. According to this publication, the number of genes in the human genome is about 35000 genes, including tens of thousands of STR (Short Tandem Repeat) loci that are applied to determine ancestry and trace individuals.
Colonel Ha Quoc Khanh (Former Director of the DNA Testing Center - Institute of Criminal Sciences; Former Deputy Director of the Institute of Criminal Sciences - Ministry of Public Security; Senior Scientific Advisor of GENTIS) shared about the history of DNA testing
In 1991, Prof. Thomas Caskey and colleagues at Baylor University, Texas, made a recommendation to use Short Tandem Repeat (STR) in criminal DNA testing. Accordingly, Promega Group and Perkin Elmer together with molecular biology company Roche have successfully manufactured STR commercial kits for use in DNA testing. STRs are superior to VNTRs because their repeats are only 2-5 base pairs and multiplex units are from 100 to 500 base pairs, capable of performing DNA ploidy reactions of many different STR locus. In particular, it is very suitable for samples with small quantities or poor quality such as criminal traces.
In 1992, Sasch Willuweit, together with Lutz Loewer and colleagues, researched and applied the Y sex chromosome to determine blood relationships. In terms of genetics, the Y chromosome is inherited only by the paternal lineage; therefore, the Y chromosome only analyzes and compares between people of the male gender to see if they have the same bloodline according to the paternal line. Subsequently, this group of authors built the YHRD online analysis tool to analyze and compare based on Y-STRs of human populations around the world.
In 2003, Szibor and colleagues studied and proposed the application of the X sex chromosome in determining blood relations. The application of sex chromosome X in the determination of blood relationship is considered an adjunct to the STR autosomal analysis method when this method cannot be conclusive, such as analyzing the blood relationship between father and daughter or grandmother-granddaughter in case the father is unable to provide a sample.
In 1993, the first STR kit was introduced and put into use; initially those were just kits using a single locus, then were Duplex kits such as TPOX/CSF1PO; triple-kit (Triplex) including TH01/F13A/FES or CFS1PO/TH01/TPOX (CTT)... But today, most laboratories use kits ranging from 16, 17, 18 or 24 STR locus. These kits are made by Promega, Thermo Fisher Scientific and Qiagen. In addition, some countries also manufacture domestic kits (Inhouse) such as GoldenEye 20A, Rapit 21Plex System or AGCU 21+1 STR kits of China; Spain's DNASE 21 kit...
In 1995, the British Royal Police was the first law enforcement agency in the world to build a criminal DNA archive. Accordingly, all offenders sentenced to imprisonment are sampled for storage in the database.
In 1996, the US Federal Bureau of Investigation (FBI) began using mitochondrial DNA (mt DNA) to analyze DNA from human remains samples to determine maternal blood relations. However, this is a complex technique, which does not always achieve the desired results, but depends a lot on the quality of the sample and other professional conditions.
Then, in 1998, the FBI also began building a criminal DNA archive using the CODIS kit (13 STR locus). By 2017, the CODIS kit had increased to 20 STR locus.
According to the International Criminal Police Organization (Interpol), by 2019, 70 Interpol member countries had built criminal DNA archives.
In Vietnam, in 1999, the Institute of Criminal Sciences under the Ministry of Public Security was the first public agency to implement DNA testing to serve the professional work of the industry with synchronous and up-to-date equipment of international level at that time.
In 2007, in Copenhagen, Denmark, the International Society for Forensic Genetics (ISFG) proposed the possibility of applying Single Nucleotide Polymorphism (SNP) to criminal science. By 2014, Illumina (USA) used Next Generation Sequencing (NGS) equipment to analyze SNPs along with STRs in individual traceability, determining blood and racial relationships. If analyzed from 50 to 90 SNPs, the reliability would be equivalent to that of the CODIS kit (USA) with 13 autosomal STR locus.
Up to now, most countries in the world have introduced DNA technology into the testing work to serve the investigation, prosecution and trial of crimes as well as meet the social requirements. Therefore, research and manufacturing companies in the world have also launched many analytical equipment and test kits for this field. At the same time, the legal corridor has also been completed to ensure the legality and science of the field of DNA testing.
DNA testing was born at first mainly to solve criminal cases. Therefore, the term Forensic DNA (understood as criminal DNA) was born and has existed until now. Today, however, the subject of DNA testing is much broader.
2. Development tendencies of DNA testing
Until now, the use of STR loci (including autosomal STR, Y-STR, X-STR) along with capillary electrophoresis (CE) is considered the gold standard in DNA testing. However, with the development trend of technology and from the reality of criminal DNA testing, experts as well as technological companies have oriented the development of this field of testing in the future.
First of all, increasing the number of loci in the analysis kits to increase reliability and limit errors when analyzing cases of incest, close relatives or cases with mutations.
GENTIS - A well-trusted DNA testing center in Vietnam
Analysis of SNPs combined with STR loci to maximally use characteristics for identification of individuals, blood relations, phenotypes and races based on NGS (Next Generation Sequencing) technology. SNPs have outstanding advantages over other markers because SNPs have the advantage of very few mutations, which is suitable for analyzing criminal patterns due to the small amount of DNA or broken and denatured DNA. SNPs are not only applicable for the analysis of criminal patterns but also used in non-invasive bloodline determination and other medical applications.
Develop STR mini kits to fit criminal patterns
Improving technology, equipment and kits for rapid DNA testing. This is a new trend in developed countries to trace "hot traces" in criminal cases as well as border security control on immigration. Accordingly, a number of new devices have been born to meet this requirement.
With the DNA rapid testing equipment, there is no need for an outside laboratory and some other supporting equipment, but only the main equipment which can be easily transported, then the assessor only needs to put the sample into the device, and after 90 minutes it will produce a full genotype. The known devices include ANDE (Accelerated Nuclear DNA -Equipment), RapitHit, or SeqStudio Genetic Analyzer.
The operating principle of this type of device is that the entire analysis process from DNA extraction to analysis to produce a genotype is integrated in a chip or cartridge along with the analysis software. These devices are capable of analyzing 5 samples for a single run with 24-27 STR loci data, including both sex determination loci (Amelogenin) and Y-STR. Rapid DNA tests have been used in the US and some developed countries around the world.
In addition, some authors have also proposed the application of Indel (Insert/Delete) in DNA testing. However, these markers have not been widely applied.
Colonel Ha Quoc Khanh
The National Medical Genetics Conference 2023 was organized by the Vietnam Medical Genetics Association. This is an opportunity for domestic and international experts, scientists and doctors to meet, share and update the progress and achievements of medical examination and treatment, as well as discuss and exchange experiences together to provide solutions to complex problems related to the field of Medical Genetics, Pediatric Endocrinology, Rare Diseases, Prenatal Screening and Neonatal Screening.
GENTIS was honored to receive the Principal Sponsor Certificate at National Medical Genetics Conference 2023
The conference gathered more than 500 experts and doctors working in the fields of genetics, obstetrics and gynecology, assisted reproduction, neonatal pediatrics and related specialties nationwide. The main theme of the conference was "Genetic diagnosis, prenatal and neonatal screening" including a plenary session and 5 thematic sessions, 40 scientific reports providing useful information and knowledge on research and practice in the field of Genetics, prenatal screening and diagnosis, newborn screening.
According to the Scientific Council's assessment, this year's reports have abundant content which is highly up-to-date regarding both new medical knowledge and real-life practice. After each thematic session, the delegates had passionate discussions under the chairmanship of experienced experts, many questions were asked and answered. From there, it helps medical staff improve their knowledge, which is also the basis for research and application of optimal measures to treatment, bringing efficiency and reducing costs for patients.
GENTIS is honored to provide data about PGT testing for Assoc. Prof. Tran Duc Phan, PhD. M.D. (Chairman of the Vietnam Medical Genetics Association)
In particular, Nguyen Thi Huyen, MSc. MD. from Genetic Analysis Services Joint Stock Company (GENTIS) gave a detailed presentation on: "Newborn screening of metabolic disorders by MS/MS method: Quality of testing and clinical application" at the conference. The report of Doctor Huyen has received a lot of attention from doctors and delegates attending the conference because of the practicality of screening tests for congenital metabolic disorders in early diagnosis, timely treatment, and improving the quality of life for patients as well as reducing the burden on the family.
Not only that, GENTIS is also honored to provide data and reports on PGT and SLSS tests for congenital adrenal hyperplasia to leading experts:
- "Some trends in screening and diagnosis of genetic diseases" - Assoc. Prof. Tran Duc Phan, PhD.MD. - Chairman of the Vietnam Medical Genetics Association
- "Neonatal screening for congenital adrenal hyperplasia" - Tran Thi Chi Mai, PhD. MD. - Dean of the Department of Medical Technology, Hanoi Medical University - Head of the Department of Biochemistry, Vietnam National Hospital of Pediatrics.
- "PGT-A and mosaic embryos: from theory to practice" - Quach Thi Hoang Oanh, MsC. MD. - Deputy Head of Medical Genetic Testing Department – Tu Du Hospital
- "Mosaic embryos: from genetic screening before implantation to prenatal screening and diagnosis" - Specialist level 2 Nguyen Van Thong - Hung Vuong General Hospital
The report of Nguyen Thi Huyen, MsC.MD. (GENTIS Company) received a lot of attention from doctors and delegates present at the conference
The reports received high appreciation from the Scientific Council, doctors, and delegates present at the conference. Through the reports, GENTIS hopes to introduce genetic tests, prenatal screening, and newborn screening more widely to doctors and experts. GENTIS will always develop and update the best and most advanced testing services and kits for customers and partners with the goal of improving the physical and intellectual quality of Vietnamese people.
Especially, accompanying the National Medical Genetics Conference in 2023, GENTIS also brought a booth to introduce products. Here, doctors and experts had the opportunity to access GENTIS's comprehensive genetic testing ecosystem, participate in minigames, and receive many valuable gifts. GENTIS will always develop and update the best and most advanced testing services and packages for customers and partners with the goal of improving the physical and intellectual quality of Vietnamese people. Once again, congratulations on the great success of the Conference.
This football competition provides an opportunity for the GENTIS family to engage in meaningful exchange, foster a sense of unity, and enhance their overall well-being through physical exercise. Furthermore, the event serves to elevate the sports culture within the organization and solidify the bonds between GENTIS and our esteemed business partners.
The SUPERCUP 2023 football tournament features the participation of 4 teams representing the following organizations:
- GENTIS Genetic Analysis Services Joint Stock Company
- IVF Department of Hong Ngoc Hospital & Hong Ngoc Phuc Truong Minh
- Hanoi General Hospital
- VITECH Company
The tournament consists of 4 participating teams, divided into 2 semi-final matchups through a random draw. The 2 winning semi-finalists will then compete in the championship match, while the 2 losing semi-finalists will play a match for the third place. All the matches will be held on a single day, October 15th, 2023. Each match will consist of 2 halves, each lasting 25 minutes, and a 5-minute break between the halves.
The matches will be contested under the current 7-a-side football laws, with no limit on the number of player substitutions permitted during a match. The referee will have full decision-making authority over all incidents and occurrences on the football field.
For the semi-final and final matches, if the result cannot be decided after the two regulation halves of play, the outcome will be determined through a penalty kick shootout. Each team will be allocated 5 penalty kick attempts, and if the scores remain tied, the teams will continue with a "golden goal" penalty shootout until a winner is found.
Don't forget to be present at the Hanoi University Football Stadium (Hanoi University, 264 Nguyen Trai) at 8:30 am on October 15, 2023 to cheer on the participating teams. Notably, the 2023 Super Cup will offer free admission to all passionate spectators for all matches.
If you are unable to attend in person, do not worry - simply connect to the internet and access the GENTIS Fanpage to watch live streams of all the matches. The live stream broadcast will be available globally, enabling you to show your support for your beloved teams from anywhere.
Established on October 26, 2010, by a team of leading scientists in the fields of diagnostics and biotechnology, GENTIS has continuously grown to become a trusted name in genetic testing. We are proud to be a reliable partner of hospitals, clinics, and a trusted healthcare companion for Vietnamese families.
Moreover, GENTIS has become a second home to nearly 200 employees. With our united spirit and commitment to "Breakthrough together", the GENTIS team promises to deliver even more impressive achievements in the coming year.
To celebrate our 13th anniversary, all GENTIS employees are invited to join us in a series of exciting events throughout October.
Sales race (September 26 - October 24): Having revenue is having everything - Revenue is power. Four teams: Customer Service, Online Business HCM, Offline Business HN, Offline Business HCM are ready to participate in creating a breakthrough this October. The entire company will stand together, enthusiastically support and strongly cheer for all 4 highest winning racing teams.
3rd Annual Football Super Cup (Oct 15 - 22): A great opportunity to connect GENTIS with our partners and clients while showcasing our team spirit.
Men in Bloom (Oct 20): The first event appearing at GENTIS, this is not a playground for women but this is the "headquarters" for GENTIS men to express their creativity, skillful techniques to collectively create beautiful flower vases for GENTIS women.
Interdepartmental musical performance: Sweet or personality, gentle or hot, you don't have to choose because GENTIS-ers have them all. Rolling cultural performances have always been GENTIS's specialty for the past 13 years. Look forward to excellent performances with 3 inter-departmental entertainment teams at the gala night of October 25.
GENTIS Teambuilding + Gala Dinner: This is definitely an indispensable event at GENTIS: Fiery teambuilding and heroic GALA night are always long for and carefully prepared by all GENTIS employees.
Detailed information about GENTIS's 13th birthday celebration program will be continuously updated at the GENTIS Fan Page and website www.gentis.com.vn. Please look forward to it and join GENIS!
High-risk individuals and the Etiological Factors of Preeclampsia
GENTIS Participated in the ASRM 2023 Scientific Congress & Expo
Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) and What You Need to Know
Tay Ho District honors GENTIS as an exemplary enterprise in 2023.
History of DNA testing and development tendencies
GENTIS participated in the National Medical Genetics Conference 2023 as the main sponsor as well as a report participant
The vibrant SUPERCUP 2023 football tournament celebrated the 13th anniversary of the GENTIS’s foundation
GENTIS 13th Anniversary: Strong Foundation - Breakthrough together
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