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An alarming fact is that the rate of female infertility is gradually rejuvenating and increasing, many women worry that they do not know the cause of infertility, how it manifests, the methods of infertility treatment, the time of infertility. When is the golden point to examine and treat infertility and infertility?
Not only that, the pregnancy journey is a challenging and arduous journey. For pregnant mothers with in vitro fertilization (IVF), the journey is even more difficult. IVF pregnancy management plays an extremely important role, from the time the embryo is formed, transferred to the mother's uterus until the baby is born safely, healthy and limiting unwanted problems. may occur such as miscarriage, fetal growth arrest, premature birth, haemorrhage, etc. to the mother; low birth weight, malnutrition, fetal malformations, jaundice, infections, respiratory failure, etc. for children.
Understanding that, Hanoi General Hospital cooperated with GENTIS to organize a seminar: "Optimizing female infertility treatment - Increasing the success rate combined with IVF pregnancy management" for customers to have More information, awareness about female infertility treatment and IVF pregnancy management.
This seminar has the participation of two speakers who are two leading experts in the field of reproductive support and obstetrics and gynecology:
- Master, Doctor Nguyen Thi Thu - Head of Hanoi Center for Infertility and Sex Medicine.
- Associate Professor, Dr. Vu Ba Quyet - Former Director of the National Hospital of Obstetrics and Gynecology, Standing Vice Chairman of the Executive Committee of the Vietnam Association of Obstetrics and Gynecology, the title of People's Doctor, Labor Medal III and Class 3 II, member of the Gentis Scientific Council.During the seminar with all customers, the couples listened to Dr. Nguyen Thi Thu share about the issues related to the concept, causes of female infertility, as well as the optimal solution, the timing of female infertility. gold during IVF.
As for Assoc. Prof. Dr. Vu Ba Quyet, he shared about potential risks and notes during IVF pregnancy. In addition, the program also had the presence of a couple who successfully performed IVF right from the first time of embryo transfer, Ms. Thu's family was very touched and sent special thanks to the doctors at the hospital. Hanoi General Hospital. Happiness burst on their faces after holding their first child in the arms of their first child after 9 years of marriage.
The seminar was successfully held with the enthusiastic response of infertile couples. In the near future, GENTIS & IVF Hanoi will organize more medical seminars with the aim of providing useful knowledge to infertile couples; At the same time, we bring preferential gift programs to customers, supporting you in your journey to find your baby.
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Andrology is still a hot topic today for clinicians as well as infertile couples because the impact of male infertility on male reproductive health accounts for 40-50%. After many online broadcasts on the topic of male infertility, GENTIS has received a lot of positive feedback and responses from the audience.
Following this series of successes, GENTIS is pleased to discuss with a leading expert and many years of clinical practical experience in andrology, that is: MSc Duong Quang Huy - Specialist in Andrology & Infertility Ho Chi Minh City with the topic "WARNING CAUSE OF Male Infertility - Loss of AZF segment".
According to Dr. Huy at the seminar, the current situation of infertility in Vietnamese families is increasing, accounting for about 10-12% of couples of reproductive age (According to Dr. Ministry of Health). In particular, Following this series of successes, GENTIS is pleased to discuss with a leading expert and many years of clinical practical experience in andrology, that is: MSc Duong Quang Huy - Specialist in Andrology & Infertility Ho Chi Minh City with the topic "WARNING CAUSE OF Male Infertility - Loss of AZF segment".male infertility accounts for up to 40% and there are many causes for it.
Besides a number of causes such as high heat work factors, radiation…; environmental factors; having male diseases…, genetic factors causing azoospermia or azoospermia is one of the most common causes.Male infertility specialist said that until now, almost all male infertility cases were ordered to carry out chromosomal (chromosomal) related tests. However, in some cases, the chromosomal mutation causes the loss of a small gene on the Y chromosome, making it undetectable by conventional methods. Then we will need to perform AZF gene testing to detect mutations in the Y chromosome, find out where the deletion is on the Y chromosome or whether there is a repeat or an inversion.
THE STATUS AND IMPACT OF AZF on male reproduction
AZF stands for Azoospermia Factor and this region contains many genes involved in spermatogenesis. Deleting mutations occurring in the AZF region often lead to consequences with varying degrees of impact, such as azoospermia, oligospermia, severe oligospermia, disorders in spermatogenesis, or sperm abnormalities. .
According to Dr. Huy, the AZF mutation accounts for 1/2000-3000 in the world population and accounts for a very large proportion of over 7% for male infertility patients who have a semen analysis without sperm. There are four types of AZF deletions, and the effects of each deletion cause different mutations and abnormalities.
AZFa region: A complete deletion in the AZFa region means that sperm cannot be retrieved from the testes for ICSI.
Experts shared that AZFa deletion is quite rare, surgery will not find sperm in this case. Since there is no chance of having a baby from his own sperm, male patients should perform a sperm request for IVF.AZFb region: Partial deletion of the AZFb region is associated with abnormalities in spermatogenesis. Small deletions in the AZFb region with seminal spermatogenesis (SGA) phenotype
According to Dr. Huy, there are 10-15% of cases of AZFb deletion with poor sperm production, depending on the examination case, it is advisable not to intervene to find sperm to do IVF.AZFc region: AZFc deletion can show a relatively diverse phenotype, ranging from normal sperm levels, oligospermia, severe oligospermia or azoospermia.
• The highest incidence of AZFc deletion, about 85% as shared by Dr. Huy. Clinical manifestations of AZFc deletion include azoospermia, motility, or less than normal sperm count.
• In men with azoospermia due to AZFc deletion, about 70% still have a chance to find sperm using TESE technique and be able to give birth using ICSI method.
• Loss of AZFc segment alone should only be treated to obtain sperm until eligible for assisted reproductive technology, medical treatment to the extent that natural pregnancy can be achieved without assisted reproduction is ineffective.AZFd region: This region has a higher rate of deletion mutations than other regions in patients with infertility due to azoospermia or severe oligospermia with abnormal sperm morphology. Therefore, identifying AZFd deletion also means that men in a state of infertility are not severe, the treatment is better than AZFa, AZFb and AZFc deletion, but most still need fertility support.
AZF EXAMINATION PROCEDURE AND INSTRUCTIONS
Discussing at the seminar, Doctor Duong Quang Huy emphasized the need to learn the medical history of men and directly examine the male genitals in the male infertility examination process. For the cases of semen analysis without sperm, testicle size is smaller than normal, FSH is significantly increased, testosterone is decreased, etc., it is necessary to specify more in-depth genetic tests.
According to the World Health Organization (WHO), according to the European and American Association of Urology, the AZF test should be performed for men with a sperm concentration of less than 15 million sperm/ml, accompanied by clinical symptoms examination as above.
In some cases, if a man has been examined and determined to have another condition such as sperm blockage, he may not need an AZF test. The doctor also noted with male patients, if AZFc is not detected early, from low sperm count, it can lead to azoospermia and can no longer take sperm for IVF.
To evaluate the significance and importance of performing the test always requires research and scientific evidence. The male and female expert shared that, since 1992, the researches on AZF were first published and received much controversy. To date, there have been more than 900 studies on how AZF affects men, how it affects conception, how it affects men's lives, is it inherited to the next generation... Some typical examples research on AZF such as:
- M.B. Shamsi et al (2011), “Genetic and epigenetic factors: Role in male infertility”
- Vollrath, Foote D, Hilton S et al (1992). The human Y chromosome: A 43-interval map based on naturally occurring deletions. Science, 258, 52-59
- Liu XG et al (2016), “Correlation between Y chromosome microdeletion and male infertility”Thanks to these worldwide studies, in Vietnam in recent years, fertility doctors and gynecologists have had a more accurate view of the effects of AZF, thereby planning diagnosis and treatment. the right direction for the patient.
Doctor Duong Quang Huy further emphasized that analysis of AZF deletion cannot use the usual Karyotype method because it can only evaluate the number and structure of chromosomes, it is necessary to use PCR method. to amplify the male DNA, combining the use of primers (kit test) and electrophoresis to detect AZF deletions on the Y chromosome. Dr. Huy noted the importance of the test procedure. Labs need to follow the regulations and choose the right primer test kit to avoid false positives/negatives.
Sharing at the end of the seminar, Dr. Huy highly appreciated GENTIS in the implementation of the male test kit in general and the AZF test in particular. “In my opinion, GENTIS's AZF result sheet has reached all the required index thresholds for doctors to give directions for indications, diagnosis and treatment of patients. When implementing the expanded AZF test package, there will be more comprehensive and comprehensive result index thresholds. In addition, GENTIS result information is carefully sent back to the email to the doctor and the patient.”
GENTIS Company is proud to be the unit that develops a full and complete set of male tests for more than 30 fertility support units across the country. Compared to other units, GENTIS has always proven to be different and superior in technology and ensures the accuracy of AZF tests. By PCR technique to amplify specific DNA fragment combined with capillary electrophoresis system, AZF test results at GENTIS ensure adequate index threshold with AZFa, AZFb, AZFc, AZFd regions.
Hopefully, with the test that GENTIS deploys with male infertility patients, doctors will have a better direction to diagnose and treat the disease, and soon bring happiness to the infertile family. The useful information that Ths.BS Duong Quang Huy shared in the program "You ask - Expert answers" this time has contributed to providing knowledge about male infertility and loss of AZF segment to men. and infertile families. GENTIS promises to continue to bring more programs to serve doctors and customers.
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With the desire to bring the most useful and general information to couples performing IVF treatment, IVF Center - Hai Phong International Hospital for Obstetrics and Children (HP Fertility) organized a reproductive health consultation workshop on the occasion: 02 years of accompanying infertile couples on December 17.
Many statistics have shown that men also have a significant rate of infertility (about 40%). The main gynecological tests are therefore highly appreciated by medical professionals in the process of finding the cause and treatment of infertility for couples.
Many current studies show that the most common causes of male infertility are genes and chromosomes, in which about 10-15% of azoospermia cases and 5% of oligospermia have genetic abnormalities.
In addition, there are many genetic causes of male infertility, in which the lack of sperm in sufficient quantity and quality is the leading factor causing difficulty in conceiving.
Therefore, with the desire to bring the most overview of male infertility, at the Conference, Ms. Nguyen Quang Vinh - Director of Gentis Testing Center has shared in detail about the current situation of male infertility and the full set of GENTIS male tests including:
• Immunochemistry
• Karyotype
• The micro mutation loses the AZF . segment
• Sperm DNA fragmentation
• Mutation in the CFTR gene
• Anti-sperm antibodies (ASA - Antisperm Antibody)
• Sperm aneuploidy (SAA)
• Sexually Transmitted Agents (STDs)In addition, there are answers to questions directly from BSCKI Nguyen Duc Thuan (Head of HP Fertility Fertility Center, Hai Phong Obstetrics and Gynecology Hospital) in the article "Common causes of infertility in women" and from "Xu" new direction in improving the quality of transferred embryos” of MSc. Dang Truong Son (Head of HP Fertility IVF Lab, Hai Phong Obstetrics and Gynecology Hospital)
Through the Workshop, GENTIS believes that couples doing IVF have the most insight into the common causes of infertility, receive answers and advice on the journey to finding a child, and can also develop a plan of examination and treatment appropriate to each of their conditions.
Also at the seminar, GENTIS and doctors at Hai Phong Obstetrics and Gynecology Hospital presented gifts, prizes, vouchers worth up to 400,000,000 million VND to lucky couples participating in the game. Lucky Draw.
Pioneering in the field of genetic analysis in Vietnam, GENTIS will always make breakthrough efforts and research to bring new solutions and tests to contribute to improving the success rate in Assisted Reproductive Medicine!
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GENTIS would like to congratulate the Fertility Support Seminar 2022 - Hai Phong International Obstetrics and Pediatrics Hospital on a great success.
On December 10, Nghe An Department of Health, Nghe An Obstetrics and Children's Hospital solemnly held the expanded Nghe An Obstetrics and Pediatrics Scientific Conference in 2022.
Attending the conference, on the side of the Ministry of Health, there were Assoc. Prof. Dr. Nguyen Thi Lien Huong - Deputy Minister of Health; Prof. Dr. Nguyen Viet Tien - Former Deputy Minister of Health, Chairman of the Vietnam Association of Obstetricians and Gynecologists.
At the conference, there were also many domestic and foreign scientists, medical experts, and doctors working in medical units such as Assoc.Prof.Dr. Tran Minh Dien - Director of Tu Children's Hospital, Assoc. Tran Danh Cuong - Director of the National Hospital of Obstetrics and Gynecology, Assoc. Nguyen Thanh Hung - Director of Children's Hospital I, PhD. Michael Richardson - Asia Sales Manager Thermo Fisher Scientific…
The Expanded Science Conference on Obstetrics and Gynecology in 2022 is a large scientific forum, creating a driving force for the specialty of Obstetrics and Gynecology in Nghe An province to develop more strongly. Through reports sharing experiences and knowledge of leading experts, the team of doctors and staff in Nghe An health sector can learn and update a lot of professional knowledge and treatment regimens. Thereby, doctors and nurses have the opportunity to improve their qualifications, skills and quality of medical examination and treatment in order to better serve the care and health protection of the people in general and in Obstetrics and Gynecology. Nhi in particular.
The conference received nearly 1,000 invited delegates with 74 scientific research presentations by 56 professors, doctors, doctors; observed 2 surgical cases from the Department of Pediatric Surgery and Outpatient Surgery, which were broadcast live from the operating room of Nghe An Obstetrics and Children's Hospital.
The conference shared professional contents on: Obstetrics, gynecology, and pediatric surgery; anesthesia resuscitation; Heart; Respiratory; resuscitation; Infectious; infection control; image analysation; functional exploration; Traditional medicine, rehabilitation; testing, pathology; Nursing and taking care of patients; Hospital quality management; Information technology… presented by experienced experts at home and abroad.
Some outstanding reporting topics were shared at the plenary session and attracted a large number of delegates, such as:
- Screening and diagnosis of congenital abnormalities of the fetus by 3D and 4D ultrasound
- Application of gene technology in the field of reproductive health
- Some high techniques performed at the National Children's Hospital
- Measures to reduce Dengue hemorrhagic fever mortality, Clinical perspective
…Speaking at the conference, Assoc. Prof. Dr. Nguyen Thi Lien Huong - Deputy Minister of Health highly appreciated the organization of conferences of Nghe An health sector, especially Nghe An Obstetrics and Pediatrics Hospital with scientific contents. study is very useful. The Deputy Minister of Health highlighted the achievements and shortcomings in the current maternal, child and reproductive health care, and proposed to increase investment in facilities and equipment for maternal and child health care and nutrition activities in the area.
Speaking at the conference, Assoc. Prof. Dr. Nguyen Thi Lien Huong - Deputy Minister of Health highly appreciated the organization of conferences of Nghe An health sector, especially Nghe An Obstetrics and Pediatrics Hospital with scientific contents. study is very useful. The Deputy Minister of Health highlighted the achievements and shortcomings in the current maternal, child and reproductive health care, and proposed to increase investment in facilities and equipment for maternal and child health care and nutrition activities in the area.
In the coming time, GENTIS will always develop and update the most suitable testing services and packages with international standard technology to customers and partners in the fields of Obstetrics and Gynecology, Reproductive Support, and Pediatrics. department…
Once again, congratulations on the great success of the Conference, and let's take a look at some photos from today's event with GENTIS.
With the theme "Updating scientific and technical advances, improving efficiency in infertility treatment", the seminar created an opportunity to exchange information and knowledge among leading experts in the field of Assisted Reproductive Medicine. The delegates listened to experiences, shared and exchanged knowledge between centers and hospitals; As well as updating the latest scientific and technical advances, contributing to improving the effectiveness of infertility treatment.
The conference attracted many delegates from major hospitals across the country, as well as some prominent international reporters such as:
- Prof. Sean O'Leary, The University of Adelaide, Australia
- Prof. Stefan Director, Center of Reproductive Medicine and Andrology, University Hospital Münster, Germany
- Prof. Dr. Nguyen Dinh Tao - Chairman of HTSS
- Assoc. Prof. Dr. Nguyen Xuan Hoi - PSTW Hospital
- Assoc. Prof. Dr. Trinh The Son - General Secretary of the HTSS, Director of the Institute of Embryology LSQD
Besides, in the seminar, the latest methods of treatment and support for infertility in reproduction were exchanged and shared through typical attractive reports such as:
The studies and reports are divided into different sessions in accordance with the information that doctors and nurses are interested in, especially with discussion and sharing sections on cases, clinical situations in the industry and presenting information. provide a solution to edema in the treatment of rare infertility.
GENTIS is very honored to be accompanied and sponsored by this year's HASAM Annual Scientific Conference 2022. At the conference, GENTIS shared with many doctors and nurses about the latest testing services with many outstanding advantages. Like the QUICK NIPT non-invasive prenatal screening test, the PGT MAX 1 high-resolution test can detect additional microdeletions as small as 2Mb (associated with 2 dangerous syndromes DiGeorge and 1p36),....
Through the conference, GENTIS believes that experts and doctors have been updated with the latest information on domestic and foreign testing technologies, methods and services. GENTIS will always strive to develop and bring the most advanced and safest testing solutions for the purpose of improving the physical and mental health of Vietnamese people.
Once again, GENTIS would like to congratulate the conference on being a great success and bringing useful knowledge to doctors and nurses across the country.
In two days from December 6-7, the Vietnam Association of Obstetricians and Gynecologists successfully organized the 2022 National Congress of Obstetrics and Gynecology in both face-to-face and online form with online 3D virtual reality technology, which helped the delegates to have You can follow the conference from all over the country.
The conference consisted of 1 plenary session, 7 thematic sessions and 1 satellite conference with many domestic and foreign professional updates.
This is an annual event of the Vietnam Association of Obstetricians and Gynecologists, attracting many domestic and international experts to exchange and share clinical and subclinical experiences as well as update new knowledge in the field of obstetrics and gynecology. gynecology, neonatology and assisted reproduction.
The conference was attended by Deputy Minister of Health Do Xuan Tuyen; Former Minister of Health Nguyen Quoc Trieu and more than 1,000 delegates are experts from international organizations on Obstetrics and Gynecology such as Asian and Oceania Association of Obstetricians and Gynecologists (AOFOG), French Society of Obstetricians and Gynecologists. (CNGOF), research institutes, NGOs; scientists, researchers, experts in the field of maternal and newborn health from medical facilities, universities, and hospitals specializing in obstetrics and gynecology, obstetrics and gynecology... on country.
Speaking at the opening of the conference, Professor, Dr. Nguyen Viet Tien, President of the Vietnam Association of Obstetricians and Gynecologists emphasized that, over the past time, the Vietnam Association of Obstetricians and Gynecologists has made constant efforts in connecting and spreading knowledge, Update clinical guidelines in the field of obstetrics and gynecology such as Cervical Cancer, Endometriosis, Prenatal Screening..., and cooperate with relevant associations to organize professional activities. .
Through 34 general and topical scientific reports, extensive knowledge on Obstetrics, Reproductive Support, Vaccines, Gynecological Cancer, Cervical Cancer, Genetics... Update to all delegates
The reports are divided into different sessions in accordance with the information that doctors and nurses are interested in, especially with discussion sections, sharing about cases, clinical situations in the industry and offering solutions. help address treatment in the field of sex medicine and reproductive health.
At this year's conference, GENTIS is honored to be accompanied by providing information, research and data reports on NIPT testing in the management of multiple pregnancies.
In the report of Ths.BS Nguyen Viet Quang (Director of the National Center for Reproductive Support - National Hospital of Obstetrics and Gynecology) on the significance of NIPT test in the management of multiple pregnancies, Dr. Quang emphasized the need. when performing the NIPT Prenatal Screening test for pregnant women with multiples, especially common birth defects such as Down syndrome, Edwards, Patau... According to doctors, NIPT should be the first test for with women with multiple pregnancies.
The director of the National Center for Assisted Reproductive Medicine also said that one of the important factors determining the accuracy and effectiveness of the NIPT test with multiple pregnancies is the test technology and equipment system.
Dr. Quang pointed out studies in the world to compare the accuracy and failure rate of some technologies, and concluded that Illumina's NIPT test (USA) is nearly effective. As best, limit the proportion of samples that must be collected.
As the unit implementing NIPT test in multiple pregnancy, GENTIS is proud to be the first unit to provide NIPT non-invasive prenatal screening tests for multiple pregnancy with modern technology, advanced techniques and prevention system Tests meet ISO standards.
Through the conference, we hope that GENTIS has contributed to providing some useful information about the NIPT test in particular as well as other tests in the field of obstetrics and gynecology, assisted reproduction for doctors and experts.
GENTIS will always develop and update the best and most advanced testing services and packages to customers and partners for the purpose of improving the physical and intellectual development of Vietnamese people.
Once again, GENTIS would like to congratulate the conference on being a great success and bringing useful knowledge to doctors and nurses across the country.
After 43 years of development in the world and 23 years of development in Vietnam, the Reproductive Support industry plays an increasingly important role and has achieved remarkable success in supporting infertile couples to have a association of being a parent. However, along with many great scientific advances, the success rate of many couples has not reached the desired level.
Vietnam is one of the countries with a strong growth rate in terms of quantity and quality of infertility treatment. In order to improve the quality of treatment, scientists constantly update their knowledge, scientific and technical advances and continue to share experiences in IVF.
Hanoi Fertility Support Association organized the third annual scientific conference with the theme "Updating scientific and technical advances, improving effectiveness in infertility treatment".
This is a particularly attractive seminar with the gathering of the best quality reports from internationally renowned experts (Germany, Australia, Singapore...), as well as experienced domestic experts.
Information about the Conference:
Time to take place: 10-11/12/2022.
Number of attendees: 250 people
Delegates: Executive Board of Hanoi Reproductive Support Association, embryologists/Labor/Clinical doctors, leaders of leading Reproductive Support Centers in the North, Central and South regions. Foreign HTSS experts.
Location: Meliá Hanoi Hotel, 44 Ly Thuong Kiet, Hoan Kiem, City. Hanoi
Main content:
Participating in this year's conference, GENTIS promises to bring doctors and specialists a complete set of the latest testing techniques for clinical application in disease diagnosis and treatment. GENTIS would like to wish the Conference a great success. Let's update more information about the Conference at GENTIS Website and Fanpage!
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Therefore, on December 3, Hanoi Hospital for Andrology and Infertility cooperated with the Military Radio and Television Center to organize a Gala "Seeds of Aspiration" with the theme "Supporting soldiers who are infertile". - Spread love. This is a cultural and artistic program that tells the emotional story of barren soldiers, about the painful and hard journey to find a child.
During the program, the audience heard the confidants, stories, cries, laughter, mixed joys and sorrows of military couples when the dream of having children seemed to be extinguished. but lit up by the light of hope from the "Seed of Desire". 10 100% free in vitro fertilization cases have been announced and given to 10 infertile military families with the most difficult and disadvantaged circumstances. Tears of happiness rolled down her cheeks when she was held in the arms of little angels after 9 years, 10 years of waiting, these wonderful emotions were flooded on the Gala night "Seeds of Desire".
GENTIS is very honored and proud to be able to contribute, share, open up the same concerns, with a burning desire to be called the two-language darling of military families. GENTIS would like to wish all the medical staff and hospital staff a lot of health to help many infertile couples achieve more dreams, joy and happiness.
Thank you to Hanoi Hospital for Male Studies and Infertility and the Military Radio and Television Center for organizing a special art program, a Gala night full of meaningful happiness and love.
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